Vol 2, No 4 (1998)
Prace oryginalne
Published online: 2000-03-08
Get Citation

Relationship between Serum Lipids and Angiotensin Converting Enzyme Activity in Cholesterol-fed Rabbits

Marcin Stajszczyk, Jan Gmiński, Wojciech Wojakowski, Krzysztof Siemianowicz, Małgorzata Goss, Marek Machalski
Nadciśnienie tętnicze 1998;2(4):213-217.
Vol 2, No 4 (1998)
Prace oryginalne
Published online: 2000-03-08

Abstract


Background Blockade of renin-angiotensin system reduces the development of atherosclerotic plaque in different animal models. In some experimental studies improvement of lipids metabolism was also observed after treatment with ACE-inhibitors. There is still little known about the mechanism of ACE-inhibitors action on lipids metabolism in hypercholesterolemic animals.
Methods The aim of the study was to assess the renin-angiotensin system activity in experimentally-induced hypercholesterolemia and the possible relationships between lipids parameters and ACE activity. Twenty male New-Zealand rabbits were divided into two groups with the following dietary conditions: standard diet (n = 10) and 1% cholesterol diet (n = 10). After six months of experiment the blood was collected for analysis of ACE activity and lipids. Total, LDL and HDL cholesterol, triglycerides, phospholipids and ACE activity was measured enzymatically.
Results At the end of the experiment there were no correlations between ACE activity and serum lipids in normolipidemic group. When compared with the control group, in cholesterol-fed rabbits ACE activity was increased (p < 0.05). We observed a positive correlation between ACE activity and serum triglycerides (r = 0.6%, p < 0.04) and inverse correlation between ACE activity and HDL cholesterol (r = -0.89, p < 0.001) in hypercholesterolemic rabbits. There was no correlation between ACE activity and any other lipids parameters in this group.
Conclusions We have shown that standard diet supplemented with 1% cholesterol leads to increased activation of ACE and that there is a correlation between this activity and triglycerides and HDL cholesterol metabolism. This may be in part responsible for the observed changes in lipids metabolism after ACE-inhibitors in hyperlipidemic animals and then be one of the antiatherosclerotic properties of ACE-inhibitors.

Abstract


Background Blockade of renin-angiotensin system reduces the development of atherosclerotic plaque in different animal models. In some experimental studies improvement of lipids metabolism was also observed after treatment with ACE-inhibitors. There is still little known about the mechanism of ACE-inhibitors action on lipids metabolism in hypercholesterolemic animals.
Methods The aim of the study was to assess the renin-angiotensin system activity in experimentally-induced hypercholesterolemia and the possible relationships between lipids parameters and ACE activity. Twenty male New-Zealand rabbits were divided into two groups with the following dietary conditions: standard diet (n = 10) and 1% cholesterol diet (n = 10). After six months of experiment the blood was collected for analysis of ACE activity and lipids. Total, LDL and HDL cholesterol, triglycerides, phospholipids and ACE activity was measured enzymatically.
Results At the end of the experiment there were no correlations between ACE activity and serum lipids in normolipidemic group. When compared with the control group, in cholesterol-fed rabbits ACE activity was increased (p < 0.05). We observed a positive correlation between ACE activity and serum triglycerides (r = 0.6%, p < 0.04) and inverse correlation between ACE activity and HDL cholesterol (r = -0.89, p < 0.001) in hypercholesterolemic rabbits. There was no correlation between ACE activity and any other lipids parameters in this group.
Conclusions We have shown that standard diet supplemented with 1% cholesterol leads to increased activation of ACE and that there is a correlation between this activity and triglycerides and HDL cholesterol metabolism. This may be in part responsible for the observed changes in lipids metabolism after ACE-inhibitors in hyperlipidemic animals and then be one of the antiatherosclerotic properties of ACE-inhibitors.
Get Citation

Keywords

angiotensin converting enzyme; hypercholesterolemia; atherosclerosis; triglycerides

About this article
Title

Relationship between Serum Lipids and Angiotensin Converting Enzyme Activity in Cholesterol-fed Rabbits

Journal

Arterial Hypertension

Issue

Vol 2, No 4 (1998)

Pages

213-217

Published online

2000-03-08

Bibliographic record

Nadciśnienie tętnicze 1998;2(4):213-217.

Keywords

angiotensin converting enzyme
hypercholesterolemia
atherosclerosis
triglycerides

Authors

Marcin Stajszczyk
Jan Gmiński
Wojciech Wojakowski
Krzysztof Siemianowicz
Małgorzata Goss
Marek Machalski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl