Polymorphism of the Angiotensin-converting Gene in Relation to Familial History of Hypertension

Abstract

Background The aim of the study was to indicate if the familial history of hypertension is associate with DD genotype of ACE. Methods The study was performed in 54 patients. The group I consisted of 23 persons without of arterial hypertension (13 without and 10 with familial history of hypertension). In the group II there were 31 patients with essential hypertension (14 without and 17 with familial history of hypertension). The PCR metod was used to determine the ACE genotype.
Results The observed ACE genotype frequencies in the group I were 13% for II, 65% for ID, 22% for DD while in group II 42%, 48% and 10% respectevely. No significant differences in ACE genotype distribution between studied groups were observed. The frequency of DD genotype was the same, both in subjects with and without familial history of the arterial hypertension (7.4%).
Conclusion No evidence was obtained, that the presence of hypertension or familial history of hypertension are associated with frequent occurrence of ACE gene