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Vol 3, No 1 (1999)
Editorial
Published online: 2000-03-08
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The Sympathetic Nervous System in Hypertension

Krzysztof Narkiewicz, Andrzej Rynkiewicz, Virend K. Somer
Nadciśnienie tętnicze 1999;3(1):1-8.
Vol 3, No 1 (1999)
Artykuły redakcyjne
Published online: 2000-03-08

Abstract

The sympathetic nervous system plays a central role in cardiovascular regulation in both health and disease. Sympathetic activation may be implicated in the pathogenesis of hypertension, coronary artery disease, cardiac arrhythmias and heart failure. This review focuses on sympathetic neural mechanisms in hypertension. We will review first, methods for studying sympathetic activity in humans; second, the cardiovascular ef fects of sympathetic activation; third, the evidence for sympathetic overactivity in hypertension; fourth, the nęural mechanisms enhancing sympathetic drive in hypertension; and fifth, the importance of humoral and metabolic mechanisms in sympathetic activation. While fundamental concepts outlined in earlier reviews [l, 2] will be revisited, emphasis will be placed on more recent developments.

Abstract

The sympathetic nervous system plays a central role in cardiovascular regulation in both health and disease. Sympathetic activation may be implicated in the pathogenesis of hypertension, coronary artery disease, cardiac arrhythmias and heart failure. This review focuses on sympathetic neural mechanisms in hypertension. We will review first, methods for studying sympathetic activity in humans; second, the cardiovascular ef fects of sympathetic activation; third, the evidence for sympathetic overactivity in hypertension; fourth, the nęural mechanisms enhancing sympathetic drive in hypertension; and fifth, the importance of humoral and metabolic mechanisms in sympathetic activation. While fundamental concepts outlined in earlier reviews [l, 2] will be revisited, emphasis will be placed on more recent developments.
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Keywords

baroreflex; blood pressure; cardiovascular reflexes; catecholamines; heart rate; hypertension; review; sympathetic nervous system

About this article
Title

The Sympathetic Nervous System in Hypertension

Journal

Arterial Hypertension

Issue

Vol 3, No 1 (1999)

Article type

Editorial

Pages

1-8

Published online

2000-03-08

Page views

866

Bibliographic record

Nadciśnienie tętnicze 1999;3(1):1-8.

Keywords

baroreflex
blood pressure
cardiovascular reflexes
catecholamines
heart rate
hypertension
review
sympathetic nervous system

Authors

Krzysztof Narkiewicz
Andrzej Rynkiewicz
Virend K. Somer

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