open access

Vol 3, No 4 (1999)
REVIEV
Published online: 2000-03-09
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Insulin Resistance and Method of it Diagnosis in Patients with Essential Hypertension

Jerzy Głuszek, Anna Boruczkowska
Nadciśnienie tętnicze 1999;3(4):245-250.

open access

Vol 3, No 4 (1999)
REVIEV
Published online: 2000-03-09

Abstract

Insulin resistance occurs in a considerable number of diseases, especially in all the patients with obesity and hypertension and in almost 50% of slim patients with essential hypertension. Mechanisms leading to prereceptor, receptor and postreceptor insulin resistance with special auention paid to those changes which may occur in essential hypertension have been discussed in this study The methods used to diagnose insulin resistance are based on simultaneous measuring of insulin and glucose concentration in blood serum. The most exact methods of estimating insulin resistance consist in measuring glucose and insulin concentration in serum during steady-state, quantitatively defined glucose or insulin infusion at such a speed that the physiological glucose concentration in blood serum can be maintained. Both methods however- i. e. steady-state plasma glucose as well as metabolic clamp are laboratorious and tiresome for the patient. Nuclear magnetic resonance and administrating marked glucose, insulin, amino acids and fats have been used to estimate the degree of insulin sensitivity. The insulin clamp method, however, still remains the golden standard. High relationship between binding to erythrocyte receptors and insulin resistance measured by clamp technique glues the possibility of rapid and exact estimation of insulin sensitivity in patients with essential hypertension.

Abstract

Insulin resistance occurs in a considerable number of diseases, especially in all the patients with obesity and hypertension and in almost 50% of slim patients with essential hypertension. Mechanisms leading to prereceptor, receptor and postreceptor insulin resistance with special auention paid to those changes which may occur in essential hypertension have been discussed in this study The methods used to diagnose insulin resistance are based on simultaneous measuring of insulin and glucose concentration in blood serum. The most exact methods of estimating insulin resistance consist in measuring glucose and insulin concentration in serum during steady-state, quantitatively defined glucose or insulin infusion at such a speed that the physiological glucose concentration in blood serum can be maintained. Both methods however- i. e. steady-state plasma glucose as well as metabolic clamp are laboratorious and tiresome for the patient. Nuclear magnetic resonance and administrating marked glucose, insulin, amino acids and fats have been used to estimate the degree of insulin sensitivity. The insulin clamp method, however, still remains the golden standard. High relationship between binding to erythrocyte receptors and insulin resistance measured by clamp technique glues the possibility of rapid and exact estimation of insulin sensitivity in patients with essential hypertension.
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Keywords

insulin resistance; euglycenic insulin clamp; insulin receptors; essential hypertension

About this article
Title

Insulin Resistance and Method of it Diagnosis in Patients with Essential Hypertension

Journal

Arterial Hypertension

Issue

Vol 3, No 4 (1999)

Pages

245-250

Published online

2000-03-09

Bibliographic record

Nadciśnienie tętnicze 1999;3(4):245-250.

Keywords

insulin resistance
euglycenic insulin clamp
insulin receptors
essential hypertension

Authors

Jerzy Głuszek
Anna Boruczkowska

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