Vol 3, No 4 (1999)
Review paper
Published online: 2000-03-09
Insulin Resistance and Method of it Diagnosis in Patients with Essential Hypertension
Jerzy Głuszek, Anna Boruczkowska
Nadciśnienie tętnicze 1999;3(4):245-250.
Vol 3, No 4 (1999)
REVIEV
Published online: 2000-03-09
Abstract
Insulin resistance occurs in a considerable number of diseases, especially in all the patients with obesity and hypertension and in almost 50% of slim patients with essential hypertension. Mechanisms leading to prereceptor, receptor and
postreceptor insulin resistance with special auention paid to
those changes which may occur in essential hypertension have
been discussed in this study The methods used to diagnose
insulin resistance are based on simultaneous measuring of
insulin and glucose concentration in blood serum. The most
exact methods of estimating insulin resistance consist in
measuring glucose and insulin concentration in serum during steady-state, quantitatively defined glucose or insulin infusion at such a speed that the physiological glucose concentration in blood serum can be maintained. Both methods
however- i. e. steady-state plasma glucose as well as metabolic clamp are laboratorious and tiresome for the patient.
Nuclear magnetic resonance and administrating marked glucose, insulin, amino acids and fats have been used to estimate the degree of insulin sensitivity. The insulin clamp
method, however, still remains the golden standard.
High relationship between binding to erythrocyte receptors and insulin resistance measured by clamp technique
glues the possibility of rapid and exact estimation of insulin
sensitivity in patients with essential hypertension.
Abstract
Insulin resistance occurs in a considerable number of diseases, especially in all the patients with obesity and hypertension and in almost 50% of slim patients with essential hypertension. Mechanisms leading to prereceptor, receptor and
postreceptor insulin resistance with special auention paid to
those changes which may occur in essential hypertension have
been discussed in this study The methods used to diagnose
insulin resistance are based on simultaneous measuring of
insulin and glucose concentration in blood serum. The most
exact methods of estimating insulin resistance consist in
measuring glucose and insulin concentration in serum during steady-state, quantitatively defined glucose or insulin infusion at such a speed that the physiological glucose concentration in blood serum can be maintained. Both methods
however- i. e. steady-state plasma glucose as well as metabolic clamp are laboratorious and tiresome for the patient.
Nuclear magnetic resonance and administrating marked glucose, insulin, amino acids and fats have been used to estimate the degree of insulin sensitivity. The insulin clamp
method, however, still remains the golden standard.
High relationship between binding to erythrocyte receptors and insulin resistance measured by clamp technique
glues the possibility of rapid and exact estimation of insulin
sensitivity in patients with essential hypertension.
Keywords
insulin resistance; euglycenic insulin clamp; insulin receptors; essential hypertension
Title
Insulin Resistance and Method of it Diagnosis in Patients with Essential Hypertension
Journal
Arterial Hypertension
Issue
Vol 3, No 4 (1999)
Article type
Review paper
Pages
245-250
Published online
2000-03-09
Page views
1134
Article views/downloads
19287
Bibliographic record
Nadciśnienie tętnicze 1999;3(4):245-250.
Keywords
insulin resistance
euglycenic insulin clamp
insulin receptors
essential hypertension
Authors
Jerzy Głuszek
Anna Boruczkowska
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