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Scal Polymorphism of the Atrial Natriuretic Peptide Gene and Blood Preassure in Subjects without Clinical Manifestations of Atherosclerotic Disease
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Abstract
Background The complex system of natriuretic peptides plays important role in the pathogenesis of the cardiovascular diseases. It is involved in the regulation ofhomeostasis and blood pressure. The aim of our study was to assess the atrial natriuretic peptide gene (ANP gene) polymorphic variants in subjects without clinical manifestations of atherosclerotic diseases. The ANP gene polymorphism distribution was compared with blood pressure and other risk factors of atherosclerosis distribution.
Material and methods We examined 424 subjects, 346 men mean age 44 ± 9 years and 78 women, mean age 45 ± 7 years, who did not have any symptoms of coronary artery disease, stroke or other atherosclerotic diseases. We measured blood pressure, weight, height, waist and hip circumference, fasting serum glucose and lipids levels. In each subject resting ecg was recorded. The polymerase chain reaction and agarose gel electrophoresis were used to determine the Scal ANP genotype.
Results There was no significant difference in the genotype distribution and allel frequency between subjects with normal (A2A2 - 72%, A2A1 + AlAl - 28%, allel A1 -16%, allel A2- 84% in men and A2A2- 76%, A2A1 + + A1A1- 24%, allel A1 -12%, allel A2 - 88% in women) and high blood pressure (A2A2 - 66%, A2A1 + A1A1 - 34%, allel A1 -19%, allel A2 - 81% in men and A2A2 -62%,A2Al +A1A1-38%, allelAl -20%, allelA2- 80% in women). Distribution of common atherosclerosis risk factors was independent from ANP gene Scal polymorphism. There was also no significant difference in the genotype distribution between subjects with low (< 5%) and high ( > 20%) risk of coronary event for men and women.
Conclusions It seems that the presence of a particular ANP gene Scal polymorphic variant has no significant influence on blood pressure level and other studied risk factors of atherosclerosis.
Abstract
Background The complex system of natriuretic peptides plays important role in the pathogenesis of the cardiovascular diseases. It is involved in the regulation ofhomeostasis and blood pressure. The aim of our study was to assess the atrial natriuretic peptide gene (ANP gene) polymorphic variants in subjects without clinical manifestations of atherosclerotic diseases. The ANP gene polymorphism distribution was compared with blood pressure and other risk factors of atherosclerosis distribution.
Material and methods We examined 424 subjects, 346 men mean age 44 ± 9 years and 78 women, mean age 45 ± 7 years, who did not have any symptoms of coronary artery disease, stroke or other atherosclerotic diseases. We measured blood pressure, weight, height, waist and hip circumference, fasting serum glucose and lipids levels. In each subject resting ecg was recorded. The polymerase chain reaction and agarose gel electrophoresis were used to determine the Scal ANP genotype.
Results There was no significant difference in the genotype distribution and allel frequency between subjects with normal (A2A2 - 72%, A2A1 + AlAl - 28%, allel A1 -16%, allel A2- 84% in men and A2A2- 76%, A2A1 + + A1A1- 24%, allel A1 -12%, allel A2 - 88% in women) and high blood pressure (A2A2 - 66%, A2A1 + A1A1 - 34%, allel A1 -19%, allel A2 - 81% in men and A2A2 -62%,A2Al +A1A1-38%, allelAl -20%, allelA2- 80% in women). Distribution of common atherosclerosis risk factors was independent from ANP gene Scal polymorphism. There was also no significant difference in the genotype distribution between subjects with low (< 5%) and high ( > 20%) risk of coronary event for men and women.
Conclusions It seems that the presence of a particular ANP gene Scal polymorphic variant has no significant influence on blood pressure level and other studied risk factors of atherosclerosis.
Keywords
ScaI ANP gene polymorphism; arterial hypertension; risk factors of atherosclerosis
Title
Scal Polymorphism of the Atrial Natriuretic Peptide Gene and Blood Preassure in Subjects without Clinical Manifestations of Atherosclerotic Disease
Journal
Issue
Article type
Original paper
Pages
227-232
Published online
2000-03-09
Page views
671
Article views/downloads
1138
Bibliographic record
Nadciśnienie tętnicze 1999;3(4):227-232.
Keywords
ScaI ANP gene polymorphism
arterial hypertension
risk factors of atherosclerosis
Authors
Jerzy Bellwon
Marcin Gruchała
Janusz Siebert
Bartosz Wasąg
Karolina Ochman
Radosław Targoński
Witold Dubaniewicz
Dariusz Ciewierz
Andrzej Rynkiewicz