open access

Vol 3, No 4 (1999)
Prace oryginalne
Published online: 2000-03-09
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Scal Polymorphism of the Atrial Natriuretic Peptide Gene and Blood Preassure in Subjects without Clinical Manifestations of Atherosclerotic Disease

Jerzy Bellwon, Marcin Gruchała, Janusz Siebert, Bartosz Wasąg, Karolina Ochman, Radosław Targoński, Witold Dubaniewicz, Dariusz Ciewierz, Andrzej Rynkiewicz
Nadciśnienie tętnicze 1999;3(4):227-232.

open access

Vol 3, No 4 (1999)
Prace oryginalne
Published online: 2000-03-09

Abstract


Background The complex system of natriuretic peptides plays important role in the pathogenesis of the cardiovascular diseases. It is involved in the regulation ofhomeostasis and blood pressure. The aim of our study was to assess the atrial natriuretic peptide gene (ANP gene) polymorphic variants in subjects without clinical manifestations of atherosclerotic diseases. The ANP gene polymorphism distribution was compared with blood pressure and other risk factors of atherosclerosis distribution.
Material and methods We examined 424 subjects, 346 men mean age 44 ± 9 years and 78 women, mean age 45 ± 7 years, who did not have any symptoms of coronary artery disease, stroke or other atherosclerotic diseases. We measured blood pressure, weight, height, waist and hip circumference, fasting serum glucose and lipids levels. In each subject resting ecg was recorded. The polymerase chain reaction and agarose gel electrophoresis were used to determine the Scal ANP genotype.
Results There was no significant difference in the genotype distribution and allel frequency between subjects with normal (A2A2 - 72%, A2A1 + AlAl - 28%, allel A1 -16%, allel A2- 84% in men and A2A2- 76%, A2A1 + + A1A1- 24%, allel A1 -12%, allel A2 - 88% in women) and high blood pressure (A2A2 - 66%, A2A1 + A1A1 - 34%, allel A1 -19%, allel A2 - 81% in men and A2A2 -62%,A2Al +A1A1-38%, allelAl -20%, allelA2- 80% in women). Distribution of common atherosclerosis risk factors was independent from ANP gene Scal polymorphism. There was also no significant difference in the genotype distribution between subjects with low (< 5%) and high ( > 20%) risk of coronary event for men and women.
Conclusions It seems that the presence of a particular ANP gene Scal polymorphic variant has no significant influence on blood pressure level and other studied risk factors of atherosclerosis.

Abstract


Background The complex system of natriuretic peptides plays important role in the pathogenesis of the cardiovascular diseases. It is involved in the regulation ofhomeostasis and blood pressure. The aim of our study was to assess the atrial natriuretic peptide gene (ANP gene) polymorphic variants in subjects without clinical manifestations of atherosclerotic diseases. The ANP gene polymorphism distribution was compared with blood pressure and other risk factors of atherosclerosis distribution.
Material and methods We examined 424 subjects, 346 men mean age 44 ± 9 years and 78 women, mean age 45 ± 7 years, who did not have any symptoms of coronary artery disease, stroke or other atherosclerotic diseases. We measured blood pressure, weight, height, waist and hip circumference, fasting serum glucose and lipids levels. In each subject resting ecg was recorded. The polymerase chain reaction and agarose gel electrophoresis were used to determine the Scal ANP genotype.
Results There was no significant difference in the genotype distribution and allel frequency between subjects with normal (A2A2 - 72%, A2A1 + AlAl - 28%, allel A1 -16%, allel A2- 84% in men and A2A2- 76%, A2A1 + + A1A1- 24%, allel A1 -12%, allel A2 - 88% in women) and high blood pressure (A2A2 - 66%, A2A1 + A1A1 - 34%, allel A1 -19%, allel A2 - 81% in men and A2A2 -62%,A2Al +A1A1-38%, allelAl -20%, allelA2- 80% in women). Distribution of common atherosclerosis risk factors was independent from ANP gene Scal polymorphism. There was also no significant difference in the genotype distribution between subjects with low (< 5%) and high ( > 20%) risk of coronary event for men and women.
Conclusions It seems that the presence of a particular ANP gene Scal polymorphic variant has no significant influence on blood pressure level and other studied risk factors of atherosclerosis.
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Keywords

ScaI ANP gene polymorphism; arterial hypertension; risk factors of atherosclerosis

About this article
Title

Scal Polymorphism of the Atrial Natriuretic Peptide Gene and Blood Preassure in Subjects without Clinical Manifestations of Atherosclerotic Disease

Journal

Arterial Hypertension

Issue

Vol 3, No 4 (1999)

Pages

227-232

Published online

2000-03-09

Bibliographic record

Nadciśnienie tętnicze 1999;3(4):227-232.

Keywords

ScaI ANP gene polymorphism
arterial hypertension
risk factors of atherosclerosis

Authors

Jerzy Bellwon
Marcin Gruchała
Janusz Siebert
Bartosz Wasąg
Karolina Ochman
Radosław Targoński
Witold Dubaniewicz
Dariusz Ciewierz
Andrzej Rynkiewicz

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