Influence of Nicardipin on Microalbuminuria in Hypertension Patients

Abstract

Background: Microalbuminuria can be uesd in the risk stratification of patients with essential hypertension. A cluster of cardiovascular risk factors may be associated with microalbuminuria in hypertension. Effect of calcium blockers on urinary albumin excretion rate in patients with primary hypertension is not identical in meaning. The aim of the study was to estimate the influence of nicardipine on 24-h microalbuminuria and minuting albumin excretion after physical exercises in patients with primary hypertension.
Material and Methods: The study was performed on two 15-person group patients wish essential hypertension. In the first group 24-h microalbuminuria was measured before and after nicardipin therapy. In the second group patients were made two-hour urine colection for albumin after 5 minutes physical exercises before and after two weeks of nicardipine therapy.
Results: Atfter the therapy with nicardipine, systolic and diastolic blood pressure was significantly decreased in both groups. We observed significant positive correlations between microalbuminuria and systolic and diastolic blood pressure. We obserwed also positive correlation between reduction of diastolic blood pressure and decrease of albuminuria in patients after physical exercises. This diminution in 42% was dependent from blood pressure reduction. We did not observed the same correlation in the first group of patients for 24-h microalbuminuria.
Conclusions: 1. These data suggest that in patients with primary hypertension even the increase systolic and diastolic blood pressure increases albumin excretion rate. 2. In hypertensive patients the therapy with nicardipine significantly decreased 24-h microalbuminuria as weel as excretion of the protein was induced by physical exercises. 3. Diminiution of microalbuminuria diuring nicardipins therapy is caused by specific mechanism of drug and only in small degree dependent on blood pressure reduction.