open access

Vol 4, No 3 (2000)
Prace oryginalne
Published online: 2000-07-20
Get Citation

Blood Pressure Variability and Smoothness Index after 6 Antihypertensive Drugs

Halina Adamska-Dyniewska, Wojciech Ptaszyński
Nadciśnienie tętnicze 2000;4(3):181-186.

open access

Vol 4, No 3 (2000)
Prace oryginalne
Published online: 2000-07-20

Abstract


Background The aim of the study was to recognize, if long-acting hypertensive drugs reduce the blood pressure variability, in comparison with placebo.
Material and methods The study group consisted of 100 patients with mild or moderate essential hypertension. Ambulatory blood pressure monitoring (ABPM) was performed after placebo and after six drugs: bisoprolol — 5 mg (n = 19), perindopril — 4 mg (n = 15), verapamil 120–240 mg (n = 21), nitrendipine — 10 mg (n = 17), candesartan — 16 mg (n = 15), and losartan — 50 mg (n = 13). On the base of ABPM it was calculated: the mean 24-h arterial blood pressure (BP) reduction, the trough/peak index, and the smoothness index (method of [14]), corrected in relation to placebo (Slc).
Results The reduction of the mean 24-h BP was significant after 5 drugs (except losartan). The highest reduction was present after perindopril. The trough/peak index after six drugs was ł 50%, in them after bisoprolol and perindopril >60%. The trend of BP variability reduction (calculated from SD) was observed after all drugs. After bisoprolol and candesartan the BP variability decreased statistical significantly. The smoothness index after six drugs varied from 0,24 to 1,36.
Conclusion On the base of global analyse of ABPM parameters, it was concluded that bisoprolol, candesartan and perindopril reduced variability of diastolic blood pressure in the most significant degree.

Abstract


Background The aim of the study was to recognize, if long-acting hypertensive drugs reduce the blood pressure variability, in comparison with placebo.
Material and methods The study group consisted of 100 patients with mild or moderate essential hypertension. Ambulatory blood pressure monitoring (ABPM) was performed after placebo and after six drugs: bisoprolol — 5 mg (n = 19), perindopril — 4 mg (n = 15), verapamil 120–240 mg (n = 21), nitrendipine — 10 mg (n = 17), candesartan — 16 mg (n = 15), and losartan — 50 mg (n = 13). On the base of ABPM it was calculated: the mean 24-h arterial blood pressure (BP) reduction, the trough/peak index, and the smoothness index (method of [14]), corrected in relation to placebo (Slc).
Results The reduction of the mean 24-h BP was significant after 5 drugs (except losartan). The highest reduction was present after perindopril. The trough/peak index after six drugs was ł 50%, in them after bisoprolol and perindopril >60%. The trend of BP variability reduction (calculated from SD) was observed after all drugs. After bisoprolol and candesartan the BP variability decreased statistical significantly. The smoothness index after six drugs varied from 0,24 to 1,36.
Conclusion On the base of global analyse of ABPM parameters, it was concluded that bisoprolol, candesartan and perindopril reduced variability of diastolic blood pressure in the most significant degree.
Get Citation

Keywords

blood pressure variability; smoothness index; trough/peak index; hypotensive drugs

About this article
Title

Blood Pressure Variability and Smoothness Index after 6 Antihypertensive Drugs

Journal

Arterial Hypertension

Issue

Vol 4, No 3 (2000)

Pages

181-186

Published online

2000-07-20

Bibliographic record

Nadciśnienie tętnicze 2000;4(3):181-186.

Keywords

blood pressure variability
smoothness index
trough/peak index
hypotensive drugs

Authors

Halina Adamska-Dyniewska
Wojciech Ptaszyński

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl