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Blood Pressure Variability and Smoothness Index after 6 Antihypertensive Drugs
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Abstract
Background The aim of the study was to recognize, if long-acting hypertensive drugs reduce the blood pressure variability, in comparison with placebo.
Material and methods The study group consisted of 100 patients with mild or moderate essential hypertension. Ambulatory blood pressure monitoring (ABPM) was performed after placebo and after six drugs: bisoprolol — 5 mg (n = 19), perindopril — 4 mg (n = 15), verapamil 120–240 mg (n = 21), nitrendipine — 10 mg (n = 17), candesartan — 16 mg (n = 15), and losartan — 50 mg (n = 13). On the base of ABPM it was calculated: the mean 24-h arterial blood pressure (BP) reduction, the trough/peak index, and the smoothness index (method of [14]), corrected in relation to placebo (Slc).
Results The reduction of the mean 24-h BP was significant after 5 drugs (except losartan). The highest reduction was present after perindopril. The trough/peak index after six drugs was ł 50%, in them after bisoprolol and perindopril >60%. The trend of BP variability reduction (calculated from SD) was observed after all drugs. After bisoprolol and candesartan the BP variability decreased statistical significantly. The smoothness index after six drugs varied from 0,24 to 1,36.
Conclusion On the base of global analyse of ABPM parameters, it was concluded that bisoprolol, candesartan and perindopril reduced variability of diastolic blood pressure in the most significant degree.
Abstract
Background The aim of the study was to recognize, if long-acting hypertensive drugs reduce the blood pressure variability, in comparison with placebo.
Material and methods The study group consisted of 100 patients with mild or moderate essential hypertension. Ambulatory blood pressure monitoring (ABPM) was performed after placebo and after six drugs: bisoprolol — 5 mg (n = 19), perindopril — 4 mg (n = 15), verapamil 120–240 mg (n = 21), nitrendipine — 10 mg (n = 17), candesartan — 16 mg (n = 15), and losartan — 50 mg (n = 13). On the base of ABPM it was calculated: the mean 24-h arterial blood pressure (BP) reduction, the trough/peak index, and the smoothness index (method of [14]), corrected in relation to placebo (Slc).
Results The reduction of the mean 24-h BP was significant after 5 drugs (except losartan). The highest reduction was present after perindopril. The trough/peak index after six drugs was ł 50%, in them after bisoprolol and perindopril >60%. The trend of BP variability reduction (calculated from SD) was observed after all drugs. After bisoprolol and candesartan the BP variability decreased statistical significantly. The smoothness index after six drugs varied from 0,24 to 1,36.
Conclusion On the base of global analyse of ABPM parameters, it was concluded that bisoprolol, candesartan and perindopril reduced variability of diastolic blood pressure in the most significant degree.
Keywords
blood pressure variability; smoothness index; trough/peak index; hypotensive drugs
About this articleTitle
Blood Pressure Variability and Smoothness Index after 6 Antihypertensive Drugs
Journal
Issue
Article type
Original paper
Pages
181-186
Published online
2000-07-20
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1132
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2521
Bibliographic record
Nadciśnienie tętnicze 2000;4(3):181-186.
Keywords
blood pressure variability
smoothness index
trough/peak index
hypotensive drugs
Authors
Halina Adamska-Dyniewska
Wojciech Ptaszyński