Vol 4, No 4 (2000)
Original paper
Published online: 2000-10-30
Diurnal Blood Pressure Profile after the First Dose of Peryndopryl in Acute Myocardial Infarction
Nadciśnienie tętnicze 2000;4(4):253-260.
Abstract
Background There is lack of data on 24-hour blood pressure after the first dose of ACE inhibitor in acute myocardial infarction. Because potentially serious consequences of hypotension after the first dose of angiotensin converting enzyme inhibitors may occur the aim of our study was to evaluate the hypotensive effects of early treatment with ACE inhibitor — peryndopryl in patients with acute myocardial infarction.
Material and methods The study was performed in 58 consecutive patients with acute myocardial infarction. On the first, second or third day of acute myocardial infarction 28 patients from group I (age 60 ± 14 years, EF 52% ± 8%) received one dose of 4 mg of peryndopryl per os. Group II, not treated with ACE inhibitor, consisted of 30 patients with acute myocardial infarction (age 58 ± 12 years, EF 54% ± ± 9%). Non-invasive 24-hour ambulatory blood pressure monitoring was programed to measure blood pressure every 20 minutes during a day and every 30 minutes at night.
Results Mean 24-hour systolic blood pressure was lower in group I but not significant (110 ± 13 mm Hg vs. 119 ± ± 15 mm Hg, p = 0.057), similar there was no significant differences in diurnal mean diastolic blood pressure (70 ± ± 10 mm Hg vs. 71 ± 10 mm Hg, p = 0.8) and mean diurnal heart rate (76 ± 11/min vs. 77 ± 12/min, p = 0.8). There was significant difference in mean 24-hour SBP x HR between group I and II (8140 ± 613 vs. 8740 ± ± 637 mm Hg/min, p = 0.03).
Conclusions 24-hour blood pressure profile analysis in patients with acute myocardial infarction after the first 4 mg dose of peryndopryl (1–3 day) did not produce exacerbated hypotension. Mean diurnal double product SBP ´ HR was significantly lower in patients treated with peryndopryl.
Material and methods The study was performed in 58 consecutive patients with acute myocardial infarction. On the first, second or third day of acute myocardial infarction 28 patients from group I (age 60 ± 14 years, EF 52% ± 8%) received one dose of 4 mg of peryndopryl per os. Group II, not treated with ACE inhibitor, consisted of 30 patients with acute myocardial infarction (age 58 ± 12 years, EF 54% ± ± 9%). Non-invasive 24-hour ambulatory blood pressure monitoring was programed to measure blood pressure every 20 minutes during a day and every 30 minutes at night.
Results Mean 24-hour systolic blood pressure was lower in group I but not significant (110 ± 13 mm Hg vs. 119 ± ± 15 mm Hg, p = 0.057), similar there was no significant differences in diurnal mean diastolic blood pressure (70 ± ± 10 mm Hg vs. 71 ± 10 mm Hg, p = 0.8) and mean diurnal heart rate (76 ± 11/min vs. 77 ± 12/min, p = 0.8). There was significant difference in mean 24-hour SBP x HR between group I and II (8140 ± 613 vs. 8740 ± ± 637 mm Hg/min, p = 0.03).
Conclusions 24-hour blood pressure profile analysis in patients with acute myocardial infarction after the first 4 mg dose of peryndopryl (1–3 day) did not produce exacerbated hypotension. Mean diurnal double product SBP ´ HR was significantly lower in patients treated with peryndopryl.
Keywords: acute myocardial infarctionACE inhibitors24-hour blood pressure monitoringperyndopryl