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Diurnal Blood Pressure Profile after the First Dose of Peryndopryl in Acute Myocardial Infarction
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Abstract
Material and methods The study was performed in 58 consecutive patients with acute myocardial infarction. On the first, second or third day of acute myocardial infarction 28 patients from group I (age 60 ± 14 years, EF 52% ± 8%) received one dose of 4 mg of peryndopryl per os. Group II, not treated with ACE inhibitor, consisted of 30 patients with acute myocardial infarction (age 58 ± 12 years, EF 54% ± ± 9%). Non-invasive 24-hour ambulatory blood pressure monitoring was programed to measure blood pressure every 20 minutes during a day and every 30 minutes at night.
Results Mean 24-hour systolic blood pressure was lower in group I but not significant (110 ± 13 mm Hg vs. 119 ± ± 15 mm Hg, p = 0.057), similar there was no significant differences in diurnal mean diastolic blood pressure (70 ± ± 10 mm Hg vs. 71 ± 10 mm Hg, p = 0.8) and mean diurnal heart rate (76 ± 11/min vs. 77 ± 12/min, p = 0.8). There was significant difference in mean 24-hour SBP x HR between group I and II (8140 ± 613 vs. 8740 ± ± 637 mm Hg/min, p = 0.03).
Conclusions 24-hour blood pressure profile analysis in patients with acute myocardial infarction after the first 4 mg dose of peryndopryl (1–3 day) did not produce exacerbated hypotension. Mean diurnal double product SBP ´ HR was significantly lower in patients treated with peryndopryl.
Abstract
Material and methods The study was performed in 58 consecutive patients with acute myocardial infarction. On the first, second or third day of acute myocardial infarction 28 patients from group I (age 60 ± 14 years, EF 52% ± 8%) received one dose of 4 mg of peryndopryl per os. Group II, not treated with ACE inhibitor, consisted of 30 patients with acute myocardial infarction (age 58 ± 12 years, EF 54% ± ± 9%). Non-invasive 24-hour ambulatory blood pressure monitoring was programed to measure blood pressure every 20 minutes during a day and every 30 minutes at night.
Results Mean 24-hour systolic blood pressure was lower in group I but not significant (110 ± 13 mm Hg vs. 119 ± ± 15 mm Hg, p = 0.057), similar there was no significant differences in diurnal mean diastolic blood pressure (70 ± ± 10 mm Hg vs. 71 ± 10 mm Hg, p = 0.8) and mean diurnal heart rate (76 ± 11/min vs. 77 ± 12/min, p = 0.8). There was significant difference in mean 24-hour SBP x HR between group I and II (8140 ± 613 vs. 8740 ± ± 637 mm Hg/min, p = 0.03).
Conclusions 24-hour blood pressure profile analysis in patients with acute myocardial infarction after the first 4 mg dose of peryndopryl (1–3 day) did not produce exacerbated hypotension. Mean diurnal double product SBP ´ HR was significantly lower in patients treated with peryndopryl.
Keywords
acute myocardial infarction; ACE inhibitors; 24-hour blood pressure monitoring; peryndopryl
Title
Diurnal Blood Pressure Profile after the First Dose of Peryndopryl in Acute Myocardial Infarction
Journal
Issue
Article type
Original paper
Pages
253-260
Published online
2000-10-30
Page views
729
Article views/downloads
1217
Bibliographic record
Nadciśnienie tętnicze 2000;4(4):253-260.
Keywords
acute myocardial infarction
ACE inhibitors
24-hour blood pressure monitoring
peryndopryl
Authors
Wojciech Sobiczewski
Marcin Gruchała
Rafał Gałąska
Monika Szpajer
Krzysztof Chlebus
Anna Chorabik
Leszek Mierzejewski
Andrzej Rynkiewicz