Association of the I/D Polymorphism of ACE and A1166C Polymorphism of the Angiotensin II AT1 Receptor Gene and Blood Preassure in Men without Clinical Manifestations of Atherocslerotic Diseases

Jerzy Bellwon; Marcin Gruchała; Janusz Siebert; Bartosz Wasąg; Karolina Ochman; Radosław Targoński; Witold Dubaniewicz; Krzysztof Chlebus; Rafał Gałąska; Andrzej Rynkiewicz

Vol 4, No 4 (2000)

Original paper

Published online: 2000-10-30

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Association of the I/D Polymorphism of ACE and A1166C Polymorphism of the Angiotensin II AT1 Receptor Gene and Blood Preassure in Men without Clinical Manifestations of Atherocslerotic Diseases

Jerzy Bellwon, Marcin Gruchała, Janusz Siebert, Bartosz Wasąg, Karolina Ochman, Radosław Targoński, Witold Dubaniewicz, Krzysztof Chlebus, Rafał Gałąska, Andrzej Rynkiewicz

Nadciśnienie tętnicze 2000;4(4):261-268.

Vol 4, No 4 (2000)

Prace oryginalne

Published online: 2000-10-30

Abstract

Background Genetic and enviromental factors influence the developement of arteraial hypertension. Increased activity of the renin-angiotensin-aldosteron system can facilitate development of arteriosclerosis and may play a role in pathophysiology of arterial hypertension. We investigated the interaction between ACE gene I/D polymorphism and AT1 receptor gene A1166C polymorphism on the risk of arterial hypertension. Material and methods We examined 539 men, mean age 44 ± 9 years, who did not have any symptoms of coronary artery disease, stroke or other atherosclerotic diseases. We measured blood pressure, weight, height, weist and hip circumference, fasting serum glucose and lipids levels. In each subject resting ecg was recorded. The polymerase chain reaction, RFLP procedure and agarose gel electrophoresis were used to determine the ACE I/D genotype and the angiotensin II AT1 receptor A1166C genotype. Results The odds ratio for arterial hypertension associated with the AT1R AC+CC genotype was 0.59 (95% Cl 0.28–1.26) for men without the ACE I allele p = 0.36 and 1.26 (95% Cl 0.76–2.07) in ID heterozygotes, p = 0.36 and 0.76 (95% Cl 0.36–1.61) in II homozygotes, p = 0.61. The assoctiation was also not significant after adjustment for other significant common atherosclerotic risk factors. Conclusions We did not find any significant interaction between ACE and AT1R gene polymorphisms in men with and without arterial hypertension.

Abstract

Background Genetic and enviromental factors influence the developement of arteraial hypertension. Increased activity of the renin-angiotensin-aldosteron system can facilitate development of arteriosclerosis and may play a role in pathophysiology of arterial hypertension. We investigated the interaction between ACE gene I/D polymorphism and AT1 receptor gene A1166C polymorphism on the risk of arterial hypertension. Material and methods We examined 539 men, mean age 44 ± 9 years, who did not have any symptoms of coronary artery disease, stroke or other atherosclerotic diseases. We measured blood pressure, weight, height, weist and hip circumference, fasting serum glucose and lipids levels. In each subject resting ecg was recorded. The polymerase chain reaction, RFLP procedure and agarose gel electrophoresis were used to determine the ACE I/D genotype and the angiotensin II AT1 receptor A1166C genotype. Results The odds ratio for arterial hypertension associated with the AT1R AC+CC genotype was 0.59 (95% Cl 0.28–1.26) for men without the ACE I allele p = 0.36 and 1.26 (95% Cl 0.76–2.07) in ID heterozygotes, p = 0.36 and 0.76 (95% Cl 0.36–1.61) in II homozygotes, p = 0.61. The assoctiation was also not significant after adjustment for other significant common atherosclerotic risk factors. Conclusions We did not find any significant interaction between ACE and AT1R gene polymorphisms in men with and without arterial hypertension.

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Keywords

I/D ACE gene polymorphism; angiotensin II AT1 receptor gene polymorphism; arterial hypertension; risk factors of atherosclerosis

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Title

Association of the I/D Polymorphism of ACE and A1166C Polymorphism of the Angiotensin II AT1 Receptor Gene and Blood Preassure in Men without Clinical Manifestations of Atherocslerotic Diseases

Journal

Arterial Hypertension

Issue

Vol 4, No 4 (2000)

Article type

Original paper

Pages

261-268

Published online

2000-10-30

Page views

710

Article views/downloads

1134

Bibliographic record

Nadciśnienie tętnicze 2000;4(4):261-268.

Keywords

I/D ACE gene polymorphism
angiotensin II AT1 receptor gene polymorphism
arterial hypertension
risk factors of atherosclerosis

Authors

Jerzy Bellwon
Marcin Gruchała
Janusz Siebert
Bartosz Wasąg
Karolina Ochman
Radosław Targoński
Witold Dubaniewicz
Krzysztof Chlebus
Rafał Gałąska
Andrzej Rynkiewicz