5. Diurnal Blood Pressure Profile in Premenopausal Women with Polycystic Ovary Syndrome (PcOS) Diagnosed in Reproductive period

Abstract

Background: Polycystic ovary syndrome (PcOS) is a highly prevalent endocrine disturbance with increased risk of cardiovascular disease in premenopausal women. Metabolic disturbances, especially hyperinsulinaemia, insulin resistance, hyperlipidaemia, obesity, increase risk of elevated blood pressure and coronary heart disease in women with polycystic ovary syndrome, therefore the aim of our study was to analyze 24 hour systolic (SBP), diastolic (DBP), day and night blood pressure and heart rate (HR) in premenopausal women with diagnosed polycystic ovary syndrome with consideration of method of treatment of this syndrome.

Material and methods: The study was performed in 31 premenopausal women treated between 1975–1988 because of polycystic ovary syndrome. The group of 20 women was treated conservatively and 11 women by surgery (ovary wedge resection). Control group consisted of 22 women which were admitted to outpatient clinic for prophylactic examination; they presented no fertility problems. Mean 24 hour, day and night blood pressure performed by means of SpaceLabs 90207 monitor were statistically analyzed.

Results: Mean SBP and DBP were significantly higher in polycystic ovary syndrome group in comparison to control group (SBP 127,7 ± 9,8 mm Hg vs. 115,8 ± 7,7 mm Hg, DBP 80,9 ± 6,9 mm Hg vs. 74,2 ± 4,1 mm Hg). Differences were similar during the day and night. The highest 24-h SBP (132,2 ± 7,4 mm Hg) and DBP (83,2 ± 6,0 mm Hg) were observed in polycystic ovary syndrome women with conservative treatment. There was no significant difference in 24-h SBP and DBP between surgery treated women and control group.

Conclusions: Polycystic ovary syndrome women presented higher blood pressure measurements in premenopausal period which refers particularly to conservative treated women.