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The Impact of Trandolapryl on Some Metabolic Disturbances and Endothelium Dysfunction in Non-treated Essential Hypertensive Patients
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Abstract
Material and methods We examined 13 ambulatory patients with non-treated essential hypertension. The control group was of 14 healthy volunteers matched with age and sex. The anthropometric parameters were obtained. The 24 hour urine collection was assayed for albuminuria, creatinine and NAG excretion. The next day fasting blood was withdrawn for biochemistry, insulin, thrombomodulin, tissue plasminogen activator and vWF:Ag. The examination was repeated after 3 months of trandolapril oral 2 mg per day therapy.
Results The hypertensive group was characterized with a number of abnormalities, which stand for polymetabolic syndrome. After 3 months therapy the significant decrease of HbA1c (%) (6,01 ± 0,45 vs. 5,66 ± 0,41; p < 0,05) and increase of vWF:Ag (%) (148,08 ± 65,10 vs. 306,77 ± ± 146,63; p < 0,01) were observed.
Conclusions Our study suggests the advantage of trandolapril monotherapy on carbohydrate metabolism seen in polymetabolic syndrome but not on endothelial function despite satisfactory blood pressure control. We observed significant increase of vWF:Ag level which may be a local effect of ACE inhibitor on already injured endothelium.
Abstract
Material and methods We examined 13 ambulatory patients with non-treated essential hypertension. The control group was of 14 healthy volunteers matched with age and sex. The anthropometric parameters were obtained. The 24 hour urine collection was assayed for albuminuria, creatinine and NAG excretion. The next day fasting blood was withdrawn for biochemistry, insulin, thrombomodulin, tissue plasminogen activator and vWF:Ag. The examination was repeated after 3 months of trandolapril oral 2 mg per day therapy.
Results The hypertensive group was characterized with a number of abnormalities, which stand for polymetabolic syndrome. After 3 months therapy the significant decrease of HbA1c (%) (6,01 ± 0,45 vs. 5,66 ± 0,41; p < 0,05) and increase of vWF:Ag (%) (148,08 ± 65,10 vs. 306,77 ± ± 146,63; p < 0,01) were observed.
Conclusions Our study suggests the advantage of trandolapril monotherapy on carbohydrate metabolism seen in polymetabolic syndrome but not on endothelial function despite satisfactory blood pressure control. We observed significant increase of vWF:Ag level which may be a local effect of ACE inhibitor on already injured endothelium.
Keywords
essential arterial hypertension; von Willebrand Factor; polymetabolic syndrome
About this articleTitle
The Impact of Trandolapryl on Some Metabolic Disturbances and Endothelium Dysfunction in Non-treated Essential Hypertensive Patients
Journal
Issue
Article type
Original paper
Pages
115-124
Published online
2001-06-15
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590
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Bibliographic record
Nadciśnienie tętnicze 2001;5(2):115-124.
Keywords
essential arterial hypertension
von Willebrand Factor
polymetabolic syndrome
Authors
Marek Kretowicz
Małgorzata Ukleja-Adamowicz
Paweł Stróżecki
Krzysztof Buczkowski
Katarzyna Klucz
Ryszard Paczuski
Grażyna Odrowąż-Sypniewska
Jacek Manitius