open access

Vol 5, No 4 (2001)
Prace oryginalne
Published online: 2001-10-03
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Bronchial Hyperreactivity in Patients with Essential Hypertension Treated with Angiotensin Converting Enzyme Blockers

Ryszard Malinowski, Joanna Niegowska, Piotr Gutkowski
Nadciśnienie tętnicze 2001;5(4):269-278.

open access

Vol 5, No 4 (2001)
Prace oryginalne
Published online: 2001-10-03

Abstract

Background The aim of the paper was to assess the inci- dence and intensity of the bronchial hyperreactivity in pa- tients suffering from mild and moderate essential arterial hypertension treated with enalapril.
Material and methods 34 patients both sexes aged 27 –63 years (mean 48)treated twice daily with 20 –40 mg of ena- lapril (mean dose 20,6 mg)were studied for 12 weeks.To investigate the influence of the medication on cough and bronchial hyperreactivity (BHR)appearance the bronchial challenge test with histamine was performed before and after the first dosing day,after first 4 weeks and 12 weeks of treatment.The blood pressure was measured by routine method before each pulmonary procedure after 15 minute resting conditions.
Results During the time of investigation the blood pres- sure was reduced significantly from average 155,2/ /100,2 mm Hg before treatment and reached the normal value (mean 132,2/82,4 mm Hg)after 12 week medication. In the beginning of the observation 12/34 (35%)patients had confirmed BHR,after 12 weeks of observation the number increased to 14.The cough was present in 9/34 patients,three of them had to stop the medication due to cough intensity.Patients which had to stop the medica- tion appertained to the group of high and moderate levels of bronchial hyperreactivity.The number of patients with obstructive pattern in pulmonary function changed from 3 to 5 during the 12 weeks observation period.
Conclusions It was noticed the bronchial hyperreactivity in one-third of tested patients.The tendency to increase in bronchial reactivity in patients with blood hyperten- sion treated with angiotensin converting enzyme block- ers was observed.Dry paroxysmal cough was present only in patients with increased bronchial hyperreactivity be- fore introduction of angiotensin converting enzyme blockers.

Abstract

Background The aim of the paper was to assess the inci- dence and intensity of the bronchial hyperreactivity in pa- tients suffering from mild and moderate essential arterial hypertension treated with enalapril.
Material and methods 34 patients both sexes aged 27 –63 years (mean 48)treated twice daily with 20 –40 mg of ena- lapril (mean dose 20,6 mg)were studied for 12 weeks.To investigate the influence of the medication on cough and bronchial hyperreactivity (BHR)appearance the bronchial challenge test with histamine was performed before and after the first dosing day,after first 4 weeks and 12 weeks of treatment.The blood pressure was measured by routine method before each pulmonary procedure after 15 minute resting conditions.
Results During the time of investigation the blood pres- sure was reduced significantly from average 155,2/ /100,2 mm Hg before treatment and reached the normal value (mean 132,2/82,4 mm Hg)after 12 week medication. In the beginning of the observation 12/34 (35%)patients had confirmed BHR,after 12 weeks of observation the number increased to 14.The cough was present in 9/34 patients,three of them had to stop the medication due to cough intensity.Patients which had to stop the medica- tion appertained to the group of high and moderate levels of bronchial hyperreactivity.The number of patients with obstructive pattern in pulmonary function changed from 3 to 5 during the 12 weeks observation period.
Conclusions It was noticed the bronchial hyperreactivity in one-third of tested patients.The tendency to increase in bronchial reactivity in patients with blood hyperten- sion treated with angiotensin converting enzyme block- ers was observed.Dry paroxysmal cough was present only in patients with increased bronchial hyperreactivity be- fore introduction of angiotensin converting enzyme blockers.
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Keywords

bronchial hyperreactivity; ACE blockers; cough

About this article
Title

Bronchial Hyperreactivity in Patients with Essential Hypertension Treated with Angiotensin Converting Enzyme Blockers

Journal

Arterial Hypertension

Issue

Vol 5, No 4 (2001)

Pages

269-278

Published online

2001-10-03

Bibliographic record

Nadciśnienie tętnicze 2001;5(4):269-278.

Keywords

bronchial hyperreactivity
ACE blockers
cough

Authors

Ryszard Malinowski
Joanna Niegowska
Piotr Gutkowski

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