Diurnal Blood Pressure Profile in Premenopausal Women with Disturbed Androgen Secretion

Abstract

Background Disturbed androgen secretion in premenopausal women with ovulation disturbances is well known for a very long time.Recently numerous studies on plasma male sex hormones in women in relation to coronary heart disease and hypertension have been performed.But still we have little knowledge about risk for coronary heart disease and atherosclerosis in hyperandrogenic women in premenopausal age.The aim of our study was to analyze 24 hour systolic (SBP),diastolic (DBP),day and night blood pressure and heart rate (HR)in premenopausal women with diagnosed disturbed androgen secretion.The study was performed in 33 premenopausal women treated because of polycystic ovary syndrome.
Material and methods Control group consisted of 22 women with no fertility problems which were admitted to outpatient clinic for prophylactic examination.Mean 24 hour, day and night blood pressure performed by means of SpaceLabs 90207 monitor were statistically analyzed.
Results Mean 24 hour SBP in hyperandrogenic women was significantly higher in comparison to control group (123 ±11 mm Hg vs.115 ±8 mm Hg).Mean day and night SBP were also significantly higher in women with hyper- androgenism (day 126 ±12 mm Hg vs.120 ±9 mm Hg, night 118 ±11 mm Hg vs.109 ±9 mm Hg).There was no significant differences in 24 hour,day and night DBP, and in 24 hour and day HR.Night heart rate was signifi- cantly higher in hyperandrogenic women than in control group (75 ±9 bpm vs.70 ±5 bpm).Double product (HR Ą SBP)was significantly higher in women with hy- perandrogenism (9731 ±1197 mm Hg/min vs.7686 ± ±3115 mm Hg/min,p<0,005).
Conclusions 24 hour,day and night SBP and night heart rate were significantly higher in women with hyperandro- genism,what indicates excessive left ventricle overload in this group of women.