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The Effect of Hypertensive Therapy on Blood Pressure Variability and Dippers/Non-dippers Classification
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Abstract
Material and methods 3 groups (13 patients in every group) with essential mild-to-moderate hypertension. Each of the groups was treated with monotherapy based on a long-acting hypertensive drug given once daily: trandolapril, felodipine ER or rilmenidine. After one month of morning administration (MA) it was changed into evening routine (EA). In every patient office blood pressur (OBP) and ABPM was taken 3 times: before enrolling, after one month of MA and after one month of EA.
Results In each of examined groups, in MA and EA routine, there was significant lowering of blood pressure both in ABPM and OBP. Independent of drug used or the time of administration there were no differences in SD for different time periods in ABPM. There were no differences in requency of non-dippers among hypertensives before and after treatment (for both administration routines).
Conclusion We have shown that although 24-hour average blood pressure can be effectively reduced by antihypertensive treatment, the effect on blood pressure variability and dippers or non-dippers status is less pronounced.
Abstract
Material and methods 3 groups (13 patients in every group) with essential mild-to-moderate hypertension. Each of the groups was treated with monotherapy based on a long-acting hypertensive drug given once daily: trandolapril, felodipine ER or rilmenidine. After one month of morning administration (MA) it was changed into evening routine (EA). In every patient office blood pressur (OBP) and ABPM was taken 3 times: before enrolling, after one month of MA and after one month of EA.
Results In each of examined groups, in MA and EA routine, there was significant lowering of blood pressure both in ABPM and OBP. Independent of drug used or the time of administration there were no differences in SD for different time periods in ABPM. There were no differences in requency of non-dippers among hypertensives before and after treatment (for both administration routines).
Conclusion We have shown that although 24-hour average blood pressure can be effectively reduced by antihypertensive treatment, the effect on blood pressure variability and dippers or non-dippers status is less pronounced.
Keywords
hypertension; blood pressure variability; dippers/non-dippers; antihypertensive therapy; timing of drug administration
Title
The Effect of Hypertensive Therapy on Blood Pressure Variability and Dippers/Non-dippers Classification
Journal
Issue
Article type
Original paper
Pages
25-34
Published online
2001-12-31
Page views
571
Article views/downloads
1403
Bibliographic record
Nadciśnienie tętnicze 2002;6(1):25-34.
Keywords
hypertension
blood pressure variability
dippers/non-dippers
antihypertensive therapy
timing of drug administration
Authors
Anna Miczke
Danuta Pupek-Musialik