Tumor Necrosis Factor Alfa (TNF- a ) and Its Role in Pathogenesis of Obesity-Associated Hypertension

Abstract

The strong association between obesity and hypertension has been demonstrated in the general population. According to NHANES II study the risk of arterial hypertension is 3-times higher in obese comparing with non-obese subjects. Mechanisms involved in the development of obesity-related hypertension have not been cleary identified. Substances having hormonal features, produced by adipose tissue, need closer attention. One of the substances is tumor necrosis factor (TNF-a) - pleotropic cytokin, known primary for its role in the immune response and cancer. Its potential role in pathogensis of arterial hypertension has been analysed recently. The influence of TNF on blood pressure is probably indirect. Its action is expressed by induction of insulin resistance, increased leptin secretion, endothelin production and influence on renin-angiotensin-aldosteron system.