open access

Vol 6, No 2 (2002)
REVIEV
Published online: 2002-04-25
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Tumor Necrosis Factor Alfa (TNF- < font face=symbol > a < /font > ) and Its Role in Pathogenesis of Obesity-Associated Hypertension

Paweł Bogdański, Danuta Pupek-Musialik, Magdalena Łuczak, Maciej Cymerys, Wiesław Bryl
Nadciśnienie tętnicze 2002;6(2):133-142.

open access

Vol 6, No 2 (2002)
REVIEV
Published online: 2002-04-25

Abstract

The strong association between obesity and hypertension has been demonstrated in the general population. According to NHANES II study the risk of arterial hypertension is 3-times higher in obese comparing with non-obese subjects. Mechanisms involved in the development of obesity-related hypertension have not been cleary identified. Substances having hormonal features, produced by adipose tissue, need closer attention. One of the substances is tumor necrosis factor (TNF-a) - pleotropic cytokin, known primary for its role in the immune response and cancer. Its potential role in pathogensis of arterial hypertension has been analysed recently. The influence of TNF on blood pressure is probably indirect. Its action is expressed by induction of insulin resistance, increased leptin secretion, endothelin production and influence on renin-angiotensin-aldosteron system.

Abstract

The strong association between obesity and hypertension has been demonstrated in the general population. According to NHANES II study the risk of arterial hypertension is 3-times higher in obese comparing with non-obese subjects. Mechanisms involved in the development of obesity-related hypertension have not been cleary identified. Substances having hormonal features, produced by adipose tissue, need closer attention. One of the substances is tumor necrosis factor (TNF-a) - pleotropic cytokin, known primary for its role in the immune response and cancer. Its potential role in pathogensis of arterial hypertension has been analysed recently. The influence of TNF on blood pressure is probably indirect. Its action is expressed by induction of insulin resistance, increased leptin secretion, endothelin production and influence on renin-angiotensin-aldosteron system.
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Keywords

arterial hypertension; obesity; tumor necrosis factor; insulin resistance; leptin; endothelin

About this article
Title

Tumor Necrosis Factor Alfa (TNF-a) and Its Role in Pathogenesis of Obesity-Associated Hypertension

Journal

Arterial Hypertension

Issue

Vol 6, No 2 (2002)

Pages

133-142

Published online

2002-04-25

Bibliographic record

Nadciśnienie tętnicze 2002;6(2):133-142.

Keywords

arterial hypertension
obesity
tumor necrosis factor
insulin resistance
leptin
endothelin

Authors

Paweł Bogdański
Danuta Pupek-Musialik
Magdalena Łuczak
Maciej Cymerys
Wiesław Bryl

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