Vol 6, No 2 (2002)
Original paper
Published online: 2002-04-25
Is There a Relationship between Leptin Concentration, Sympathetic Nervous System and Left Ventricular Mass Index in Patients with Essential Hypertension According to Gender and Body Mass Index?
Nadciśnienie tętnicze 2002;6(2):91-98.
Abstract
Background The aim of the study was to evaluate the relationship between plasma leptin, sympathetic nervous system, blood pressure and left ventricular mass index in patients with essential hypertension (EH) according to gender and BMI.
Material and methods The study included 46 patients (21F, 25M; mean age: 44,0 ± 8,4 yrs) with EH. Control group consisted of 37 volunteers (19F, 18M; mean age 40,8 ± 9,8 yrs). All subjects were divided into subgroups according to gender and BMI (<25>).
Concentration of plasma leptin (RIA), catecholamines (HPLC), NPY (RIA) and body fat percentage were determined in all subjects. In addition ECHO test was performed.
Results In patients with EH plasma leptin concentration was comparable to controls, but values were significantly higher in women and in overweight patients. Plasma NA concentration was significantly elevated in overweight EH patients. No difference in NPY concentration was found in none of compared groups. LVMI was significantly higher in women with EH in comparison with controls, independently on body mass index. Multiple regression analysis indicated the relation between leptin and gender, BMI, age, systolic blood pressure and NA (r2 = 0,28, p < 0,0001) in all investigated subjects, as well as between leptin and body fat % and NA in EH patients (r2 = 0,34, p < 0,001). Multiple regression analysis indicated also the relation between leptin and LVMI, A and diastolic blood pressure (r2 = 0,54, p < 0,05) in overweight EH men as well as between leptin and age, body fat % and LVMI in overweight EH women (r2 = 0,69, p < 0,05).
Conclusion This study suggests that leptin may contribute to regulation of blood pressure through sympathetic nervous system and may have implication in pathogenesis of left ventricular hypertrophy.
Material and methods The study included 46 patients (21F, 25M; mean age: 44,0 ± 8,4 yrs) with EH. Control group consisted of 37 volunteers (19F, 18M; mean age 40,8 ± 9,8 yrs). All subjects were divided into subgroups according to gender and BMI (<25>).
Concentration of plasma leptin (RIA), catecholamines (HPLC), NPY (RIA) and body fat percentage were determined in all subjects. In addition ECHO test was performed.
Results In patients with EH plasma leptin concentration was comparable to controls, but values were significantly higher in women and in overweight patients. Plasma NA concentration was significantly elevated in overweight EH patients. No difference in NPY concentration was found in none of compared groups. LVMI was significantly higher in women with EH in comparison with controls, independently on body mass index. Multiple regression analysis indicated the relation between leptin and gender, BMI, age, systolic blood pressure and NA (r2 = 0,28, p < 0,0001) in all investigated subjects, as well as between leptin and body fat % and NA in EH patients (r2 = 0,34, p < 0,001). Multiple regression analysis indicated also the relation between leptin and LVMI, A and diastolic blood pressure (r2 = 0,54, p < 0,05) in overweight EH men as well as between leptin and age, body fat % and LVMI in overweight EH women (r2 = 0,69, p < 0,05).
Conclusion This study suggests that leptin may contribute to regulation of blood pressure through sympathetic nervous system and may have implication in pathogenesis of left ventricular hypertrophy.
Keywords: leptincatecholaminesNPYLVMIessential hypertension