open access

Vol 6, No 2 (2002)
Prace oryginalne
Published online: 2002-04-25
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Elevated Plasma Homocysteine Level as a Risk Factor for Hypertension

Jacek Kądziela, Magdalena Makowiecka-Cieśla, Zofia Dzielińska, Dariusz Sitkiewicz, Danuta Gaździk, Włodzimierz Szaroszyk, Walerian Piotrowski, Andrzej Januszewicz, Witold Rużyłło
Nadciśnienie tętnicze 2002;6(2):75-82.

open access

Vol 6, No 2 (2002)
Prace oryginalne
Published online: 2002-04-25

Abstract

Background The aim of the study was to assess the significance of association between hypertension (Ht) and circulating homocysteine concentrations.
Material and methods 88 consecutive hypertensive patients (62 men and 26 women, aged 18 to 72 years) and 120 healthy controls (87 men and 33 women, aged 32–81 years) were investigated. Homocysteine was assayed using Fluorescence Polarisation Immunoassay on the IMx Analyser made by Axis Biochemicals. Plasma folate and plasma vitamin B12 were assayed with chemiluminescency and IMMULITE Automated Analyser made by the Diagnostic Products Corporation.
Results Homocysteine concentrations were higher in patients than in controls (12,07 ± 5,1 vs. 10,72 ± 13 mmol/L, p < 0,001, adjusted for age). Elevated homocysteine level - defined as a level above the 90th percentile of the control distribution (ł 13,52 mmol/L) - was seen in 24% of the patients compared with 10% of the control group (p < 0,05). The odds ratio (OR) for Ht in persons with an elevated homocysteine level was 2,8 (95% CI 1,3-6,1, p < 0,01). After adjustment for conventional risk factors (age, gender, body mass index, smoking, family history of cardiovascular disease, hyperlipidemia), an elevated homocysteine level remained an independent risk factor for Ht (OR 6,6, 95% CI 2,3-19,1, p < 0,001). The OR for Ht of 5 mmol/L increment in homocysteine level was 1,7 (95% CI 1,1-2,6, p < 0,001), and in multivariate analysis OR was 3,8 (95% CI 1,7-8,2, p < 0,001).
Conclusion An elevated plasma homocysteine level is a strong risk factor for hypertension. A 5 mmol/L increment in total homocysteine level may be associated with at least a twofold increase of risk for hypertension.

Abstract

Background The aim of the study was to assess the significance of association between hypertension (Ht) and circulating homocysteine concentrations.
Material and methods 88 consecutive hypertensive patients (62 men and 26 women, aged 18 to 72 years) and 120 healthy controls (87 men and 33 women, aged 32–81 years) were investigated. Homocysteine was assayed using Fluorescence Polarisation Immunoassay on the IMx Analyser made by Axis Biochemicals. Plasma folate and plasma vitamin B12 were assayed with chemiluminescency and IMMULITE Automated Analyser made by the Diagnostic Products Corporation.
Results Homocysteine concentrations were higher in patients than in controls (12,07 ± 5,1 vs. 10,72 ± 13 mmol/L, p < 0,001, adjusted for age). Elevated homocysteine level - defined as a level above the 90th percentile of the control distribution (ł 13,52 mmol/L) - was seen in 24% of the patients compared with 10% of the control group (p < 0,05). The odds ratio (OR) for Ht in persons with an elevated homocysteine level was 2,8 (95% CI 1,3-6,1, p < 0,01). After adjustment for conventional risk factors (age, gender, body mass index, smoking, family history of cardiovascular disease, hyperlipidemia), an elevated homocysteine level remained an independent risk factor for Ht (OR 6,6, 95% CI 2,3-19,1, p < 0,001). The OR for Ht of 5 mmol/L increment in homocysteine level was 1,7 (95% CI 1,1-2,6, p < 0,001), and in multivariate analysis OR was 3,8 (95% CI 1,7-8,2, p < 0,001).
Conclusion An elevated plasma homocysteine level is a strong risk factor for hypertension. A 5 mmol/L increment in total homocysteine level may be associated with at least a twofold increase of risk for hypertension.
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Keywords

homocysteine; hypertension; folic acid; vitamin B12

About this article
Title

Elevated Plasma Homocysteine Level as a Risk Factor for Hypertension

Journal

Arterial Hypertension

Issue

Vol 6, No 2 (2002)

Pages

75-82

Published online

2002-04-25

Bibliographic record

Nadciśnienie tętnicze 2002;6(2):75-82.

Keywords

homocysteine
hypertension
folic acid
vitamin B12

Authors

Jacek Kądziela
Magdalena Makowiecka-Cieśla
Zofia Dzielińska
Dariusz Sitkiewicz
Danuta Gaździk
Włodzimierz Szaroszyk
Walerian Piotrowski
Andrzej Januszewicz
Witold Rużyłło

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