Vol 6, No 3 (2002)
Review paper
Published online: 2002-07-01
Adiponectin - a New Element in Pathogenesis of Insulin Resistance and Atherosclerosis
Anna Miczke, Wiesław Bryl, Danuta Pupek-Musialik
Nadciśnienie tętnicze 2002;6(3):229-238.
Vol 6, No 3 (2002)
REVIEV
Published online: 2002-07-01
Abstract
Adiponectin (APM1) is one of the protein produced in adipose tissue. The adiponectin gene, located on 3q27
chromosome, consist of 3 exons and 2 introns. APM1 is 244 amino acids protein similar to colagen VIII, Xa and
C1q complement. The adiponectin plasma concentration is decreased in obesity, insulin resistance, diabetes mellitus
2 and angina pectoris. The body mass reduction, both after dietary restriction and after surgery intervention caused lowering of plasma adiponectin level. The groving evidence
suggest that proteins produced in adipose tissue, including also adiponectin, influence the lipid accumulation in coronary arteries and the inflammatory processes in this area. It seems, that adiponectin diminish the progress of atherosclerosis processes in its early stage. The assessment of APM1 concentration can help in assessment of total coronary risk. The data prooved, that APM1 plasma concentration is significantly lower in patients with angina pectoris than in healthly control, independing on age and
BMI. APM1 is one of the proteins which seem to play a role in pathogenesis of insulin resistance. The role of
adiponectin in physiology and in pathology connected with metabolic disorders and its consequences requires
further studies.
Abstract
Adiponectin (APM1) is one of the protein produced in adipose tissue. The adiponectin gene, located on 3q27
chromosome, consist of 3 exons and 2 introns. APM1 is 244 amino acids protein similar to colagen VIII, Xa and
C1q complement. The adiponectin plasma concentration is decreased in obesity, insulin resistance, diabetes mellitus
2 and angina pectoris. The body mass reduction, both after dietary restriction and after surgery intervention caused lowering of plasma adiponectin level. The groving evidence
suggest that proteins produced in adipose tissue, including also adiponectin, influence the lipid accumulation in coronary arteries and the inflammatory processes in this area. It seems, that adiponectin diminish the progress of atherosclerosis processes in its early stage. The assessment of APM1 concentration can help in assessment of total coronary risk. The data prooved, that APM1 plasma concentration is significantly lower in patients with angina pectoris than in healthly control, independing on age and
BMI. APM1 is one of the proteins which seem to play a role in pathogenesis of insulin resistance. The role of
adiponectin in physiology and in pathology connected with metabolic disorders and its consequences requires
further studies.
Keywords
adiponectin; adipose tissue; obesity; insulin resistance; atherosclerosis
Title
Adiponectin - a New Element in Pathogenesis of Insulin Resistance and Atherosclerosis
Journal
Arterial Hypertension
Issue
Vol 6, No 3 (2002)
Article type
Review paper
Pages
229-238
Published online
2002-07-01
Page views
750
Article views/downloads
1659
Bibliographic record
Nadciśnienie tętnicze 2002;6(3):229-238.
Keywords
adiponectin
adipose tissue
obesity
insulin resistance
atherosclerosis
Authors
Anna Miczke
Wiesław Bryl
Danuta Pupek-Musialik