Kidney and Sympathetic Nervous System in Hypertension

Abstract

Nowdays in clinical investigations accented a very important influence of sympathetic overactivity in hypertension pathogenesis and progression of chronic renal failure.The correlation among renal function and sympathetic nerve system are difficult. On the one hand, the sympathetic nerve system affects renal function, i.e. renal hemodynamics flow, tubular sodium transport, renin secretion and activation of RAA system. On the other hand, the kidney is the source of activating afferent signals, presumably via stimulation of chemoreceptors and baroreceptors. The complicated mechanisms of blood pressure regulation and their correlation cause many functional and structural changes in organs and finally organs failure. Knowledge of these mechanisms give some therapeutic implications, help reduced blood pressure in hypertension patients and stopped development of functional and morphological changes in organs.