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Influence of Short- and Long-Lasting Blood Pressure Increase on the Acute Phase Proteins Secretion Profile
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Abstract
Material and methods The serum level of a1-antichymotripsin (ACT) and a1-acid glycoprotein (AGP) and the qualitative determination of the glycosylation profile was measured on the 2nd and 9th day after temporary blood pressure increase in 44 patients with essential hypertension.
Results During 36 hours, after blood pressure increase, a significant increase of AGP and ACT reactivity coefficients and levels in the serum of blood was observed. The normalization,that occurred on the 9th day, and the persistent constant increase of blood pressure resulted in the significant decrease in the levels of reactivity coefficients as well as blood serum glycoproteins.
Conclusions The qualitative and quantitative changes of the secretion profile of examined glycoproteins, in the progress of essential hypertension, indicated conclusive influence of transient blood pressure increase on acute inflammatory process generated in the blood vessels wall. The persistent, constant blood pressure increase and the therapy-dependent or selfdependent normalization of blood pressure caused the rapid decrease of the inflammatory process intensity.
Abstract
Material and methods The serum level of a1-antichymotripsin (ACT) and a1-acid glycoprotein (AGP) and the qualitative determination of the glycosylation profile was measured on the 2nd and 9th day after temporary blood pressure increase in 44 patients with essential hypertension.
Results During 36 hours, after blood pressure increase, a significant increase of AGP and ACT reactivity coefficients and levels in the serum of blood was observed. The normalization,that occurred on the 9th day, and the persistent constant increase of blood pressure resulted in the significant decrease in the levels of reactivity coefficients as well as blood serum glycoproteins.
Conclusions The qualitative and quantitative changes of the secretion profile of examined glycoproteins, in the progress of essential hypertension, indicated conclusive influence of transient blood pressure increase on acute inflammatory process generated in the blood vessels wall. The persistent, constant blood pressure increase and the therapy-dependent or selfdependent normalization of blood pressure caused the rapid decrease of the inflammatory process intensity.
Keywords
hypertension; a1-acid glycoprotein; a1-antichymotrypsin; acute-phase-reaction; arteriosclerosis
About this articleTitle
Influence of Short- and Long-Lasting Blood Pressure Increase on the Acute Phase Proteins Secretion Profile
Journal
Issue
Article type
Original paper
Pages
285-290
Published online
2002-10-18
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548
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1175
Bibliographic record
Nadciśnienie tętnicze 2002;6(4):285-290.
Keywords
hypertension
a1-acid glycoprotein
a1-antichymotrypsin
acute-phase-reaction
arteriosclerosis
Authors
Katarzyna Pawlaczyk
Magdalena Sobieska
Marcin Gabriel