open access

Vol 6, No 4 (2002)
Prace oryginalne
Published online: 2002-10-18
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Influence of Short- and Long-Lasting Blood Pressure Increase on the Acute Phase Proteins Secretion Profile

Katarzyna Pawlaczyk, Magdalena Sobieska, Marcin Gabriel
Nadciśnienie tętnicze 2002;6(4):285-290.

open access

Vol 6, No 4 (2002)
Prace oryginalne
Published online: 2002-10-18

Abstract

Background The relationship between endothelium function disorder and onset of atherogenic processes in progress of arterial hypertension can be estimated by determination of serum concentration changes of some acute phase proteins. The aim of the study was to determine if the progress of arterial hypertension cause qualitative or/and quantitative changes in secretion profile of acute phase proteins.
Material and methods The serum level of a1-antichymotripsin (ACT) and a1-acid glycoprotein (AGP) and the qualitative determination of the glycosylation profile was measured on the 2nd and 9th day after temporary blood pressure increase in 44 patients with essential hypertension.
Results During 36 hours, after blood pressure increase, a significant increase of AGP and ACT reactivity coefficients and levels in the serum of blood was observed. The normalization,that occurred on the 9th day, and the persistent constant increase of blood pressure resulted in the significant decrease in the levels of reactivity coefficients as well as blood serum glycoproteins.
Conclusions The qualitative and quantitative changes of the secretion profile of examined glycoproteins, in the progress of essential hypertension, indicated conclusive influence of transient blood pressure increase on acute inflammatory process generated in the blood vessels wall. The persistent, constant blood pressure increase and the therapy-dependent or selfdependent normalization of blood pressure caused the rapid decrease of the inflammatory process intensity.

Abstract

Background The relationship between endothelium function disorder and onset of atherogenic processes in progress of arterial hypertension can be estimated by determination of serum concentration changes of some acute phase proteins. The aim of the study was to determine if the progress of arterial hypertension cause qualitative or/and quantitative changes in secretion profile of acute phase proteins.
Material and methods The serum level of a1-antichymotripsin (ACT) and a1-acid glycoprotein (AGP) and the qualitative determination of the glycosylation profile was measured on the 2nd and 9th day after temporary blood pressure increase in 44 patients with essential hypertension.
Results During 36 hours, after blood pressure increase, a significant increase of AGP and ACT reactivity coefficients and levels in the serum of blood was observed. The normalization,that occurred on the 9th day, and the persistent constant increase of blood pressure resulted in the significant decrease in the levels of reactivity coefficients as well as blood serum glycoproteins.
Conclusions The qualitative and quantitative changes of the secretion profile of examined glycoproteins, in the progress of essential hypertension, indicated conclusive influence of transient blood pressure increase on acute inflammatory process generated in the blood vessels wall. The persistent, constant blood pressure increase and the therapy-dependent or selfdependent normalization of blood pressure caused the rapid decrease of the inflammatory process intensity.
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Keywords

hypertension; a1-acid glycoprotein; a1-antichymotrypsin; acute-phase-reaction; arteriosclerosis

About this article
Title

Influence of Short- and Long-Lasting Blood Pressure Increase on the Acute Phase Proteins Secretion Profile

Journal

Arterial Hypertension

Issue

Vol 6, No 4 (2002)

Pages

285-290

Published online

2002-10-18

Bibliographic record

Nadciśnienie tętnicze 2002;6(4):285-290.

Keywords

hypertension
a1-acid glycoprotein
a1-antichymotrypsin
acute-phase-reaction
arteriosclerosis

Authors

Katarzyna Pawlaczyk
Magdalena Sobieska
Marcin Gabriel

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