Influence of Short- and Long-Lasting Blood Pressure Increase on the Acute Phase Proteins Secretion Profile

Abstract

Background The relationship between endothelium function disorder and onset of atherogenic processes in progress of arterial hypertension can be estimated by determination of serum concentration changes of some acute phase proteins. The aim of the study was to determine if the progress of arterial hypertension cause qualitative or/and quantitative changes in secretion profile of acute phase proteins.
Material and methods The serum level of a₁-antichymotripsin (ACT) and a₁-acid glycoprotein (AGP) and the qualitative determination of the glycosylation profile was measured on the 2^nd and 9^th day after temporary blood pressure increase in 44 patients with essential hypertension.
Results During 36 hours, after blood pressure increase, a significant increase of AGP and ACT reactivity coefficients and levels in the serum of blood was observed. The normalization,that occurred on the 9^th day, and the persistent constant increase of blood pressure resulted in the significant decrease in the levels of reactivity coefficients as well as blood serum glycoproteins.
Conclusions The qualitative and quantitative changes of the secretion profile of examined glycoproteins, in the progress of essential hypertension, indicated conclusive influence of transient blood pressure increase on acute inflammatory process generated in the blood vessels wall. The persistent, constant blood pressure increase and the therapy-dependent or selfdependent normalization of blood pressure caused the rapid decrease of the inflammatory process intensity.