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Does Obesity Aggravate Inflammation in Patients with Hypertension?
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Abstract
Material and methods 32 patients with hypertension - group I, 34 patients with obesity and hypertension - group II, 16 healthy volunteers as a control were studied. We estimated dependent fat content (%FAT) by bioimpedancy. Serum concentration of tumor necrosis factor (TNF-a), interleukins (IL-4, 6, 10), C-reactive protein (CRP), insulin were measured. Insulin resistance ratio (IRI/G) was calculated as a insulin:glucose.
Results Higher concentrations of TNF-a, IL-4, IL-6, IL-10, CRP, insulin, IRI/G ratio as compared to a control were found in both groups. In group II higher TNF-a, IL-10, insulin and IRI/G and tendency to higher IL-4, IL-6, CRP as compared to group I were observed. In group II correlations between ln (TNF-a) and %FAT and IRI/G ratio were found. %FAT and TNF-a emerged as independent predictors of IRI/G ratio.
Conclusions 1. Hypertension is associated with increased level of inflammatory markers. 2. Obesity can aggravate inflammation in patients with hypertension. 3. Aggravated inflammation in obese patients should be considered as a potential proatherogenic mechanism in this group. 4. Increased plasma TNF-a, its positive correlation with IRI/G indicated that TNF-a should be considered as a potential player in the state of insulin resistance. 5. Both TNF-a and %FAT emerged as independent predictors of insulin resistance.
Abstract
Material and methods 32 patients with hypertension - group I, 34 patients with obesity and hypertension - group II, 16 healthy volunteers as a control were studied. We estimated dependent fat content (%FAT) by bioimpedancy. Serum concentration of tumor necrosis factor (TNF-a), interleukins (IL-4, 6, 10), C-reactive protein (CRP), insulin were measured. Insulin resistance ratio (IRI/G) was calculated as a insulin:glucose.
Results Higher concentrations of TNF-a, IL-4, IL-6, IL-10, CRP, insulin, IRI/G ratio as compared to a control were found in both groups. In group II higher TNF-a, IL-10, insulin and IRI/G and tendency to higher IL-4, IL-6, CRP as compared to group I were observed. In group II correlations between ln (TNF-a) and %FAT and IRI/G ratio were found. %FAT and TNF-a emerged as independent predictors of IRI/G ratio.
Conclusions 1. Hypertension is associated with increased level of inflammatory markers. 2. Obesity can aggravate inflammation in patients with hypertension. 3. Aggravated inflammation in obese patients should be considered as a potential proatherogenic mechanism in this group. 4. Increased plasma TNF-a, its positive correlation with IRI/G indicated that TNF-a should be considered as a potential player in the state of insulin resistance. 5. Both TNF-a and %FAT emerged as independent predictors of insulin resistance.
Keywords
hypertension; obesity; inflammation; insulin resistance; atherosclerosis
Title
Does Obesity Aggravate Inflammation in Patients with Hypertension?
Journal
Issue
Article type
Original paper
Pages
263-269
Published online
2002-10-18
Page views
1011
Article views/downloads
1427
Bibliographic record
Nadciśnienie tętnicze 2002;6(4):263-269.
Keywords
hypertension
obesity
inflammation
insulin resistance
atherosclerosis
Authors
Paweł Bogdański
Danuta Pupek-Musialik
Monika Szulińska
Maciej Cymerys
Wiesław Bryl
Anna Jabłecka
Jan Łącki