open access

Vol 7, No 1 (2003)
Prace oryginalne
Published online: 2003-01-16
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Relation of Pulse Pressure to Neurohumoral Factors in Patients with Primary Hypertension

Maria Witkowska, Beata Jołda-Mydłowska, Małgorzata Kobusiak-Prokopowicz
Nadciśnienie tętnicze 2003;7(1):19-26.

open access

Vol 7, No 1 (2003)
Prace oryginalne
Published online: 2003-01-16

Abstract

Background Increased pulse pressure, which is responsible for mechanical stress on blood vessels, may have a significant contribution to specific organ involvement in hypertension. The aim of the study was to determine relations between pulse pressure and neurohumoral factors which play important role in pathophysiology of hypertension.
Material and methods The study was performed in 60 patients with primary hypertension aged 18–79 yr. (average 54 ± 16 yr). According to classification of Polish Society of Hypertension patients were divided in 3 group of mild, moderate and severe hypertension and on the basis of measurements of pulse pressure (PP) were divided on three group where PP < 55 mm Hg, 55–65 mm Hg and > 65. Levels of natriuretic peptides (ANP and BNP), endothelin-1, (ET-1), neuropeptide Y (NPY) and plasma renin activity (ARO) were measured using radioimmunoassay method. In all patients echocardiography, laboratory testing of sodium and potassium serum levels and their urinary excretion were performed.
Results In patients with severe hypertension and in the group with the highest PP significant increase of ANP level compared to group with lower PP and significant correlation between PP and level of ANP and NPY was found. Contrary to ANP, level of BNP was significantly diminished in patients with severe hypertension and high PP.
Conclusion Significantly increased level of ANP and NPY in patients with the highest pulse pressure and highly significant correlation between pulse pressure and level of ANP and NPY indicates the importance of pulsatile flow for secretion of these peptides in hypertensive patients.

Abstract

Background Increased pulse pressure, which is responsible for mechanical stress on blood vessels, may have a significant contribution to specific organ involvement in hypertension. The aim of the study was to determine relations between pulse pressure and neurohumoral factors which play important role in pathophysiology of hypertension.
Material and methods The study was performed in 60 patients with primary hypertension aged 18–79 yr. (average 54 ± 16 yr). According to classification of Polish Society of Hypertension patients were divided in 3 group of mild, moderate and severe hypertension and on the basis of measurements of pulse pressure (PP) were divided on three group where PP < 55 mm Hg, 55–65 mm Hg and > 65. Levels of natriuretic peptides (ANP and BNP), endothelin-1, (ET-1), neuropeptide Y (NPY) and plasma renin activity (ARO) were measured using radioimmunoassay method. In all patients echocardiography, laboratory testing of sodium and potassium serum levels and their urinary excretion were performed.
Results In patients with severe hypertension and in the group with the highest PP significant increase of ANP level compared to group with lower PP and significant correlation between PP and level of ANP and NPY was found. Contrary to ANP, level of BNP was significantly diminished in patients with severe hypertension and high PP.
Conclusion Significantly increased level of ANP and NPY in patients with the highest pulse pressure and highly significant correlation between pulse pressure and level of ANP and NPY indicates the importance of pulsatile flow for secretion of these peptides in hypertensive patients.
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Keywords

pulse pressure; atrial natriuretic peptide; brain natriuretic peptide; neuropeptide Y; endothelin-1; plasma renin activity

About this article
Title

Relation of Pulse Pressure to Neurohumoral Factors in Patients with Primary Hypertension

Journal

Arterial Hypertension

Issue

Vol 7, No 1 (2003)

Pages

19-26

Published online

2003-01-16

Bibliographic record

Nadciśnienie tętnicze 2003;7(1):19-26.

Keywords

pulse pressure
atrial natriuretic peptide
brain natriuretic peptide
neuropeptide Y
endothelin-1
plasma renin activity

Authors

Maria Witkowska
Beata Jołda-Mydłowska
Małgorzata Kobusiak-Prokopowicz

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