open access

Vol 7, No 1 (2003)
Prace oryginalne
Published online: 2003-01-16
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Circardian Rhythm of Blood Pressure in Patients with Early Phase of Primary Chronic Glomerulonephritis

Katarzyna Łochyńska, Andrzej Oko, Ilona Idasiak-Piechocka, Stanisław Czekalski
Nadciśnienie tętnicze 2003;7(1):7-14.

open access

Vol 7, No 1 (2003)
Prace oryginalne
Published online: 2003-01-16

Abstract

Background Disturbed circardian rhythm of blood pressure is a risk factor for cardiovascular complications. The impact of circardian blood pressure rhythm in patients with early phase of primary chronic glomerulonephritis was not studied before.
Material and methods In 23 untreated patients with early stage of primary chronic glomerulonephritis (GN) with creatinine clearance > 75 ml/min/1,73m2 the ambulatory blood pressure monitoring (ABPM) was performed.
Arterial hypertension was diagnosed when mean blood pressure (BP) during the day was > 131/84 mm Hg and the disturbed circadian BP rhythm (non-dipping) was diagnosed when the relative decrease of systolic and diastolic BP during the night was less than 10% when compared to BP during the day.
Results Hypertension was found in 3/10 patients (70%) with nephrotic syndrome (NS) and in 5/13 patients with smaller proteinuria. The disturbed circadian rhythm of BP (non-dipping) was found in 16 patients out of 23 persons investigated with similar incidence in patients with hypertension and normotensive patients. No significant differences were found when some parameters characterizing blood pressure and its diurnal rhythm were compared in patients with nephrotic syndrome and these with nonnephrotic proteinuria. The comparision of similar parameters between "dippers" and "non-dippers" also does not demonstrate significant differences.
Conclusions These results indicate that in the majority of patients with early stage of GN the daily BP rhythm is disturbed, which may be attributed to the increased sympathetic nervous system activity.

Abstract

Background Disturbed circardian rhythm of blood pressure is a risk factor for cardiovascular complications. The impact of circardian blood pressure rhythm in patients with early phase of primary chronic glomerulonephritis was not studied before.
Material and methods In 23 untreated patients with early stage of primary chronic glomerulonephritis (GN) with creatinine clearance > 75 ml/min/1,73m2 the ambulatory blood pressure monitoring (ABPM) was performed.
Arterial hypertension was diagnosed when mean blood pressure (BP) during the day was > 131/84 mm Hg and the disturbed circadian BP rhythm (non-dipping) was diagnosed when the relative decrease of systolic and diastolic BP during the night was less than 10% when compared to BP during the day.
Results Hypertension was found in 3/10 patients (70%) with nephrotic syndrome (NS) and in 5/13 patients with smaller proteinuria. The disturbed circadian rhythm of BP (non-dipping) was found in 16 patients out of 23 persons investigated with similar incidence in patients with hypertension and normotensive patients. No significant differences were found when some parameters characterizing blood pressure and its diurnal rhythm were compared in patients with nephrotic syndrome and these with nonnephrotic proteinuria. The comparision of similar parameters between "dippers" and "non-dippers" also does not demonstrate significant differences.
Conclusions These results indicate that in the majority of patients with early stage of GN the daily BP rhythm is disturbed, which may be attributed to the increased sympathetic nervous system activity.
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Keywords

blood pressure; circadian rhythm; primary chronic glomerulonephritis; early phase

About this article
Title

Circardian Rhythm of Blood Pressure in Patients with Early Phase of Primary Chronic Glomerulonephritis

Journal

Arterial Hypertension

Issue

Vol 7, No 1 (2003)

Pages

7-14

Published online

2003-01-16

Bibliographic record

Nadciśnienie tętnicze 2003;7(1):7-14.

Keywords

blood pressure
circadian rhythm
primary chronic glomerulonephritis
early phase

Authors

Katarzyna Łochyńska
Andrzej Oko
Ilona Idasiak-Piechocka
Stanisław Czekalski

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