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Circardian Rhythm of Blood Pressure in Patients with Early Phase of Primary Chronic Glomerulonephritis
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Abstract
Material and methods In 23 untreated patients with early stage of primary chronic glomerulonephritis (GN) with creatinine clearance > 75 ml/min/1,73m2 the ambulatory blood pressure monitoring (ABPM) was performed.
Arterial hypertension was diagnosed when mean blood pressure (BP) during the day was > 131/84 mm Hg and the disturbed circadian BP rhythm (non-dipping) was diagnosed when the relative decrease of systolic and diastolic BP during the night was less than 10% when compared to BP during the day.
Results Hypertension was found in 3/10 patients (70%) with nephrotic syndrome (NS) and in 5/13 patients with smaller proteinuria. The disturbed circadian rhythm of BP (non-dipping) was found in 16 patients out of 23 persons investigated with similar incidence in patients with hypertension and normotensive patients. No significant differences were found when some parameters characterizing blood pressure and its diurnal rhythm were compared in patients with nephrotic syndrome and these with nonnephrotic proteinuria. The comparision of similar parameters between "dippers" and "non-dippers" also does not demonstrate significant differences.
Conclusions These results indicate that in the majority of patients with early stage of GN the daily BP rhythm is disturbed, which may be attributed to the increased sympathetic nervous system activity.
Abstract
Material and methods In 23 untreated patients with early stage of primary chronic glomerulonephritis (GN) with creatinine clearance > 75 ml/min/1,73m2 the ambulatory blood pressure monitoring (ABPM) was performed.
Arterial hypertension was diagnosed when mean blood pressure (BP) during the day was > 131/84 mm Hg and the disturbed circadian BP rhythm (non-dipping) was diagnosed when the relative decrease of systolic and diastolic BP during the night was less than 10% when compared to BP during the day.
Results Hypertension was found in 3/10 patients (70%) with nephrotic syndrome (NS) and in 5/13 patients with smaller proteinuria. The disturbed circadian rhythm of BP (non-dipping) was found in 16 patients out of 23 persons investigated with similar incidence in patients with hypertension and normotensive patients. No significant differences were found when some parameters characterizing blood pressure and its diurnal rhythm were compared in patients with nephrotic syndrome and these with nonnephrotic proteinuria. The comparision of similar parameters between "dippers" and "non-dippers" also does not demonstrate significant differences.
Conclusions These results indicate that in the majority of patients with early stage of GN the daily BP rhythm is disturbed, which may be attributed to the increased sympathetic nervous system activity.
Keywords
blood pressure; circadian rhythm; primary chronic glomerulonephritis; early phase
About this articleTitle
Circardian Rhythm of Blood Pressure in Patients with Early Phase of Primary Chronic Glomerulonephritis
Journal
Issue
Article type
Original paper
Pages
7-14
Published online
2003-01-16
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834
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Bibliographic record
Nadciśnienie tętnicze 2003;7(1):7-14.
Keywords
blood pressure
circadian rhythm
primary chronic glomerulonephritis
early phase
Authors
Katarzyna Łochyńska
Andrzej Oko
Ilona Idasiak-Piechocka
Stanisław Czekalski