open access

Vol 7, No 1 (2003)
Artykuły redakcyjne
Published online: 2003-01-16
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Is Primary Hypertension Associated With Inborn Reduced Number of Nephrons In The Majority of Cases?

Stanisław Czekalski, Andrzej Oko
Nadciśnienie tętnicze 2003;7(1):1-6.

open access

Vol 7, No 1 (2003)
Artykuły redakcyjne
Published online: 2003-01-16

Abstract

One of the numerous hypotheses, which can explain the etiopathogenesis of primary arterial hypertension, suggested that reduced number of nephrons, which was determined during fetal development is an important factor influencing blood pressure level in adult life. The results confirming this hypothesis were published recently.
It was demonstrated, that the member of nephrons in the kidneys of hypertensive persons (without kidney disease) was significantly lower than in matched normotensive persons. The mean glomerular volume in hypertensive persons was markedly greater than in normotensives. On the strength of these data, in this review the indirect evidence suggesting that inherited reduced nephron number may depend not only on environmental factors during fetal development (malnutrition) but also on the genetic factors is presented. A hypothesis was proposed that adaptative hypertrophy of less numerous nephrons is associated with the trait of sodium sensitivity of blood pressure. The results of the described studies may be of significant importance for clarification of the pathogenesis of primary arterial hypertension.

Abstract

One of the numerous hypotheses, which can explain the etiopathogenesis of primary arterial hypertension, suggested that reduced number of nephrons, which was determined during fetal development is an important factor influencing blood pressure level in adult life. The results confirming this hypothesis were published recently.
It was demonstrated, that the member of nephrons in the kidneys of hypertensive persons (without kidney disease) was significantly lower than in matched normotensive persons. The mean glomerular volume in hypertensive persons was markedly greater than in normotensives. On the strength of these data, in this review the indirect evidence suggesting that inherited reduced nephron number may depend not only on environmental factors during fetal development (malnutrition) but also on the genetic factors is presented. A hypothesis was proposed that adaptative hypertrophy of less numerous nephrons is associated with the trait of sodium sensitivity of blood pressure. The results of the described studies may be of significant importance for clarification of the pathogenesis of primary arterial hypertension.
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Keywords

arterial hypertension; etiopathogenesis; nephron number; sodium sensitivity

About this article
Title

Is Primary Hypertension Associated With Inborn Reduced Number of Nephrons In The Majority of Cases?

Journal

Arterial Hypertension

Issue

Vol 7, No 1 (2003)

Pages

1-6

Published online

2003-01-16

Bibliographic record

Nadciśnienie tętnicze 2003;7(1):1-6.

Keywords

arterial hypertension
etiopathogenesis
nephron number
sodium sensitivity

Authors

Stanisław Czekalski
Andrzej Oko

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