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Is Primary Hypertension Associated With Inborn Reduced Number of Nephrons In The Majority of Cases?
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Abstract
It was demonstrated, that the member of nephrons in the kidneys of hypertensive persons (without kidney disease) was significantly lower than in matched normotensive persons. The mean glomerular volume in hypertensive persons was markedly greater than in normotensives. On the strength of these data, in this review the indirect evidence suggesting that inherited reduced nephron number may depend not only on environmental factors during fetal development (malnutrition) but also on the genetic factors is presented. A hypothesis was proposed that adaptative hypertrophy of less numerous nephrons is associated with the trait of sodium sensitivity of blood pressure. The results of the described studies may be of significant importance for clarification of the pathogenesis of primary arterial hypertension.
Abstract
It was demonstrated, that the member of nephrons in the kidneys of hypertensive persons (without kidney disease) was significantly lower than in matched normotensive persons. The mean glomerular volume in hypertensive persons was markedly greater than in normotensives. On the strength of these data, in this review the indirect evidence suggesting that inherited reduced nephron number may depend not only on environmental factors during fetal development (malnutrition) but also on the genetic factors is presented. A hypothesis was proposed that adaptative hypertrophy of less numerous nephrons is associated with the trait of sodium sensitivity of blood pressure. The results of the described studies may be of significant importance for clarification of the pathogenesis of primary arterial hypertension.
Keywords
arterial hypertension; etiopathogenesis; nephron number; sodium sensitivity
Title
Is Primary Hypertension Associated With Inborn Reduced Number of Nephrons In The Majority of Cases?
Journal
Issue
Article type
Editorial
Pages
1-6
Published online
2003-01-16
Page views
830
Article views/downloads
1113
Bibliographic record
Nadciśnienie tętnicze 2003;7(1):1-6.
Keywords
arterial hypertension
etiopathogenesis
nephron number
sodium sensitivity
Authors
Stanisław Czekalski
Andrzej Oko