open access

Vol 7, No 3 (2003)
Prace oryginalne
Published online: 2003-07-21
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Plasma Leptin Concentration and Blood Pressure Rhythm in Obese Patients with Essential Hypertension

Bogna Puciłowska, Katarzyna Paschalis-Purtak, Jadwiga Janas, Piotr Hoffman, Marek Konka, Dariusz Sitkiewicz, Marek Kabat, Andrzej Januszewicz
Nadciśnienie tętnicze 2003;7(3):149-156.

open access

Vol 7, No 3 (2003)
Prace oryginalne
Published online: 2003-07-21

Abstract

Background Leptin, important for body weight regulation, may be involved in blood pressure regulation in essential hypertension. The aim of the study was to evaluate plasma leptin concentration in relation to diurnal blood pressure in essentially hypertensive obese patients.
Material and methods The study included 48 obese male subjects (BMI > 30 kg/m2) in the age range from 20 to 54 years: group 1 consisted of 28 obese hypertensive pts (mean age: 49 ± 10 yrs), group 2 included 20 obese normotensive subjects mean age: 46 ± 11 yrs. In both groups 24-h ABPM and echocardiographic evaluation were performed. Blood samples for leptin, insulin, angiotensin II, catecholamines and other biochemical evaluations were withdrawn.
Results Our results indicate statistically higher plasma leptin concentration in obese hypertensive patients as compared to obese normotensive subjects. A positive correlation was found between plasma leptin level and BMI in both groups (group 1: r = 0.81, p < 0.01; group 2: r = 0.83, p < 0.01). In obese hypertensive group a significant correlation was detected between plasma leptin concentration and mean values of systolic blood pressure during the day (r = 0.45, p < 0.05) and during the night (r = 0.55, p < 0.05). Also there was significant correlation between plasma leptin level and heart rate during the night (r = 0.36, p < 0.05).
Conclusion Our results indicate relationship between plasma leptin concentration and diurnal BP rhythm in obese hypertensive patients.

Abstract

Background Leptin, important for body weight regulation, may be involved in blood pressure regulation in essential hypertension. The aim of the study was to evaluate plasma leptin concentration in relation to diurnal blood pressure in essentially hypertensive obese patients.
Material and methods The study included 48 obese male subjects (BMI > 30 kg/m2) in the age range from 20 to 54 years: group 1 consisted of 28 obese hypertensive pts (mean age: 49 ± 10 yrs), group 2 included 20 obese normotensive subjects mean age: 46 ± 11 yrs. In both groups 24-h ABPM and echocardiographic evaluation were performed. Blood samples for leptin, insulin, angiotensin II, catecholamines and other biochemical evaluations were withdrawn.
Results Our results indicate statistically higher plasma leptin concentration in obese hypertensive patients as compared to obese normotensive subjects. A positive correlation was found between plasma leptin level and BMI in both groups (group 1: r = 0.81, p < 0.01; group 2: r = 0.83, p < 0.01). In obese hypertensive group a significant correlation was detected between plasma leptin concentration and mean values of systolic blood pressure during the day (r = 0.45, p < 0.05) and during the night (r = 0.55, p < 0.05). Also there was significant correlation between plasma leptin level and heart rate during the night (r = 0.36, p < 0.05).
Conclusion Our results indicate relationship between plasma leptin concentration and diurnal BP rhythm in obese hypertensive patients.
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Keywords

essential hypertension; obesity; leptin; blood pressure diurnal rhythm

About this article
Title

Plasma Leptin Concentration and Blood Pressure Rhythm in Obese Patients with Essential Hypertension

Journal

Arterial Hypertension

Issue

Vol 7, No 3 (2003)

Pages

149-156

Published online

2003-07-21

Bibliographic record

Nadciśnienie tętnicze 2003;7(3):149-156.

Keywords

essential hypertension
obesity
leptin
blood pressure diurnal rhythm

Authors

Bogna Puciłowska
Katarzyna Paschalis-Purtak
Jadwiga Janas
Piotr Hoffman
Marek Konka
Dariusz Sitkiewicz
Marek Kabat
Andrzej Januszewicz

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