Vol 7, No 3 (2003)
Original paper
Published online: 2003-07-21
Plasma Leptin Concentration and Blood Pressure Rhythm in Obese Patients with Essential Hypertension
Nadciśnienie tętnicze 2003;7(3):149-156.
Abstract
Background Leptin, important for body weight regulation, may be involved
in blood pressure regulation in essential hypertension. The aim of the study was to evaluate plasma leptin concentration in relation to diurnal blood pressure in essentially hypertensive obese patients.
Material and methods The study included 48 obese male subjects (BMI > 30 kg/m2) in the age range from 20 to 54 years: group 1 consisted of 28 obese hypertensive pts (mean age: 49 ± 10 yrs), group 2 included 20 obese normotensive subjects mean age: 46 ± 11 yrs. In both groups 24-h ABPM and echocardiographic evaluation were performed. Blood samples for leptin, insulin, angiotensin II, catecholamines and other biochemical evaluations were withdrawn.
Results Our results indicate statistically higher plasma leptin concentration in obese hypertensive patients as compared to obese normotensive subjects. A positive correlation was found between plasma leptin level and BMI in both groups (group 1: r = 0.81, p < 0.01; group 2: r = 0.83, p < 0.01). In obese hypertensive group a significant correlation was detected between plasma leptin concentration and mean values of systolic blood pressure during the day (r = 0.45, p < 0.05) and during the night (r = 0.55, p < 0.05). Also there was significant correlation between plasma leptin level and heart rate during the night (r = 0.36, p < 0.05).
Conclusion Our results indicate relationship between plasma leptin concentration and diurnal BP rhythm in obese hypertensive patients.
Material and methods The study included 48 obese male subjects (BMI > 30 kg/m2) in the age range from 20 to 54 years: group 1 consisted of 28 obese hypertensive pts (mean age: 49 ± 10 yrs), group 2 included 20 obese normotensive subjects mean age: 46 ± 11 yrs. In both groups 24-h ABPM and echocardiographic evaluation were performed. Blood samples for leptin, insulin, angiotensin II, catecholamines and other biochemical evaluations were withdrawn.
Results Our results indicate statistically higher plasma leptin concentration in obese hypertensive patients as compared to obese normotensive subjects. A positive correlation was found between plasma leptin level and BMI in both groups (group 1: r = 0.81, p < 0.01; group 2: r = 0.83, p < 0.01). In obese hypertensive group a significant correlation was detected between plasma leptin concentration and mean values of systolic blood pressure during the day (r = 0.45, p < 0.05) and during the night (r = 0.55, p < 0.05). Also there was significant correlation between plasma leptin level and heart rate during the night (r = 0.36, p < 0.05).
Conclusion Our results indicate relationship between plasma leptin concentration and diurnal BP rhythm in obese hypertensive patients.
Keywords: essential hypertensionobesityleptinblood pressure diurnal rhythm