open access

Vol 7, No 3 (2003)
Prace oryginalne
Published online: 2003-07-21
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Plasma Homocysteine and Fibrinogen Levels in Type 2 Diabetics with and without Nocturnal Blood Pressure Fall and Heart Rate Decrease

Olga Kolcowa, Elżbieta Orłowska-Kunikowska, Leszek Bieniaszewski, Ewa Semetkowska-Jurkiewicz, Krzysztof Narkiewicz, Bogdan Wyrzykowski
Nadciśnienie tętnicze 2003;7(3):141-147.

open access

Vol 7, No 3 (2003)
Prace oryginalne
Published online: 2003-07-21

Abstract

Background The link between high levels of serum homocysteine and fibrinogen and cardiovascular morbidity appears to be much stronger in diabetics than in subjects with normal glucose tolerance. It has been suggested that patients with non-dipping pattern (non-dippers) are at greater risk of target organ damage. The aim of the present study was to evaluate the relationship between blunted diurnal blood pressure and heart rate profile and serum levels of homocysteine and fibrinogen in patients with type 2 diabetes mellitus.
Material and methods We studied 87 patients with type 2 diabetes mellitus. We evaluated the impact of retinopathy and nephropathy on diurnal blood pressure and heart rate profile. The patients were grouped according to the presence or lack of nocturnal blood pressure and heart rate decrease.
Results Microalbuminuria had no significant effect on diurnal blood pressure profile. Compared to patients without retinopathy, those with this complication had significantly smaller nocturnal blood pressure fall. Non-dipping blood pressure pattern status was linked to higher levels of serum homocysteine. Patients without nocturnal heart rate decrease had significantly greater fibrinogen levels.
Conclusions Presence of retinopathy is associated with significantly blunted nocturnal blood pressure fall in type 2 diabetes. Blunted diurnal blood pressure variation in type 2 diabetics is related to higher serum levels of homocysteine. In type 2 diabetics, non-dipping pattern of heart rate profile is linked to higher serum levels of fibrinogen.

Abstract

Background The link between high levels of serum homocysteine and fibrinogen and cardiovascular morbidity appears to be much stronger in diabetics than in subjects with normal glucose tolerance. It has been suggested that patients with non-dipping pattern (non-dippers) are at greater risk of target organ damage. The aim of the present study was to evaluate the relationship between blunted diurnal blood pressure and heart rate profile and serum levels of homocysteine and fibrinogen in patients with type 2 diabetes mellitus.
Material and methods We studied 87 patients with type 2 diabetes mellitus. We evaluated the impact of retinopathy and nephropathy on diurnal blood pressure and heart rate profile. The patients were grouped according to the presence or lack of nocturnal blood pressure and heart rate decrease.
Results Microalbuminuria had no significant effect on diurnal blood pressure profile. Compared to patients without retinopathy, those with this complication had significantly smaller nocturnal blood pressure fall. Non-dipping blood pressure pattern status was linked to higher levels of serum homocysteine. Patients without nocturnal heart rate decrease had significantly greater fibrinogen levels.
Conclusions Presence of retinopathy is associated with significantly blunted nocturnal blood pressure fall in type 2 diabetes. Blunted diurnal blood pressure variation in type 2 diabetics is related to higher serum levels of homocysteine. In type 2 diabetics, non-dipping pattern of heart rate profile is linked to higher serum levels of fibrinogen.
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Keywords

diabetes mellitus; hypertension; inflammation; fibrinogen; homocysteine; risk factors

About this article
Title

Plasma Homocysteine and Fibrinogen Levels in Type 2 Diabetics with and without Nocturnal Blood Pressure Fall and Heart Rate Decrease

Journal

Arterial Hypertension

Issue

Vol 7, No 3 (2003)

Pages

141-147

Published online

2003-07-21

Bibliographic record

Nadciśnienie tętnicze 2003;7(3):141-147.

Keywords

diabetes mellitus
hypertension
inflammation
fibrinogen
homocysteine
risk factors

Authors

Olga Kolcowa
Elżbieta Orłowska-Kunikowska
Leszek Bieniaszewski
Ewa Semetkowska-Jurkiewicz
Krzysztof Narkiewicz
Bogdan Wyrzykowski

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