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Diuretics in Antihypertensive Therapy - Does History Described a Circle?
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Abstract
This review presents arguments for and against this opinion. Mechanisms of antihypertensive action of thiazide diuretics, their metabolic and electrolyte adverse reactions, end-organ protection and the results of other clinical trials are discussed and compared with placebo and other, newer antihypertensives. The authors also review the indications for thiazide diuretics in hypotensive treatment. It seems that in the light of the recent clinical trials thiazide diuretics should be used more widely but there is little evidence that they should be regarded as first line treatment in every case of hypertension.
Abstract
This review presents arguments for and against this opinion. Mechanisms of antihypertensive action of thiazide diuretics, their metabolic and electrolyte adverse reactions, end-organ protection and the results of other clinical trials are discussed and compared with placebo and other, newer antihypertensives. The authors also review the indications for thiazide diuretics in hypotensive treatment. It seems that in the light of the recent clinical trials thiazide diuretics should be used more widely but there is little evidence that they should be regarded as first line treatment in every case of hypertension.
Keywords
antihypertensive treatment; thiazide diuretics


Title
Diuretics in Antihypertensive Therapy - Does History Described a Circle?
Journal
Issue
Article type
Editorial
Pages
129-139
Published online
2003-07-21
Page views
563
Article views/downloads
1136
Bibliographic record
Nadciśnienie tętnicze 2003;7(3):129-139.
Keywords
antihypertensive treatment
thiazide diuretics
Authors
Andrzej Tykarski