Hypertension and a Function of Peroxisome Proliferator-Activated Receptor gamma

Abstract

Hypertension is one of the civilization’s disease. The coexistence of systemic metabolic disorders, especially insulin resistance, cause progression of hypertension and the risk of cardiovascular diseases in the course of atherosclerosis. This review will discuss the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in hypertension. Thiazolidinediones, which are activators PPARgamma, could be a turning-point in the treatment of polymetabolic syndrome, because of reducing of insulin resistance and hypertension at the same time.