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Relationship between Peripheral White Blood Count and Arterial Blood Pressure in Patients with Essential Hypertension
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Abstract
Material and methods In this retrospective analysis 1257 patients with essential arterial hypertension (720 M, 537 F) were included. In all examined subjects presence of secondary hypertension was excluded during hospitalization in our clinic. All patients were divided in quartile subgroups according to the peripheral leukocytes blood count. In all patients the following parameters were analyzed: arterial blood pressure (assesed twice by the Korotkow method in patients receiving a normal sodium diet and after 3 days of sodium restriction), BMI, erythrocyte sedimentation rate, serum concentrations of creatinine, uric acid, glucose, total cholesterol, plasma renin activity and blood hemoglobin concentration.
Results Patients with higher leukocyte blood count showed higher values of BMI, diastolic blood pressure (both during intake of a normal sodium diet and after 3 days of sodium restriction) and systolic blood pressure (only during sodium restriction). The lowest serum creatinine concentration but the highest serum uric acid concentration was found in a subgroup of patients with the highest leukocyte blood count. All analyzed subgroups showed a similar serum concentrations of glucose and total cholesterol. A significant positive correlation was obtained between the white blood cell count and systolic or diastolic blood pressure respectively. Multiple regression analyses for dependent variables: systolic/diastolic blood pressure revealed that leukocyte blood count weakly but significantly contributes to arterial blood pressure values.
Conclusions Results presented in this study suggest, that leukocytes (or inflammation process) may participate in the pathogenesis of essential hypertension.
Abstract
Material and methods In this retrospective analysis 1257 patients with essential arterial hypertension (720 M, 537 F) were included. In all examined subjects presence of secondary hypertension was excluded during hospitalization in our clinic. All patients were divided in quartile subgroups according to the peripheral leukocytes blood count. In all patients the following parameters were analyzed: arterial blood pressure (assesed twice by the Korotkow method in patients receiving a normal sodium diet and after 3 days of sodium restriction), BMI, erythrocyte sedimentation rate, serum concentrations of creatinine, uric acid, glucose, total cholesterol, plasma renin activity and blood hemoglobin concentration.
Results Patients with higher leukocyte blood count showed higher values of BMI, diastolic blood pressure (both during intake of a normal sodium diet and after 3 days of sodium restriction) and systolic blood pressure (only during sodium restriction). The lowest serum creatinine concentration but the highest serum uric acid concentration was found in a subgroup of patients with the highest leukocyte blood count. All analyzed subgroups showed a similar serum concentrations of glucose and total cholesterol. A significant positive correlation was obtained between the white blood cell count and systolic or diastolic blood pressure respectively. Multiple regression analyses for dependent variables: systolic/diastolic blood pressure revealed that leukocyte blood count weakly but significantly contributes to arterial blood pressure values.
Conclusions Results presented in this study suggest, that leukocytes (or inflammation process) may participate in the pathogenesis of essential hypertension.
Keywords
white blood cell count; essential hypertension; etiopathogenesis
Title
Relationship between Peripheral White Blood Count and Arterial Blood Pressure in Patients with Essential Hypertension
Journal
Issue
Article type
Original paper
Pages
253-261
Published online
2003-09-24
Page views
1210
Article views/downloads
2328
Bibliographic record
Nadciśnienie tętnicze 2003;7(4):253-261.
Keywords
white blood cell count
essential hypertension
etiopathogenesis
Authors
Małgorzata Kukla
Miłosz Zarzecki
Magdalena Szotowska
Paulina Kopeć
Ewelina Mamcarz
Zuzanna Wnuk
Rafał Wiencek
Jerzy Chudek
Franciszek Kokot
Andrzej Więcek