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Vol 7, No 4 (2003)
Prace oryginalne
Published online: 2003-09-24
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Evaluation of Atherosclerotic Risk Factors in Patients with Essential Hypertension and Coronary Arteries Disease with or without Renal Artery Stenosis

Zofia Dzielińska, Andrzej Januszewicz, Magdalena Makowiecka-Cieśla, Jacek Kądziela, Marcin Demkow, Elżbieta Florczak, Ryszard Mielniczuk, Jadwiga Janas, Magdalena Januszewicz, Aleksander Prejbisz, Tomasz Zieliński, Dariusz Rynkun, Walerian Piotrowski, Witold Rużyłło
Nadciśnienie tętnicze 2003;7(4):219-226.

open access

Vol 7, No 4 (2003)
Prace oryginalne
Published online: 2003-09-24

Abstract

Background Renal artery stenosis of atherosclerotic origin frequently coexists with atherosclerotic lesions in other vascular beds (aorta, coronary, carotid and peripheral arteries). Several risk factors contribute to the development of coronary artery disease as well as of renal artery stenosis. The aim of the study was to evaluate atherosclerotic risk factors in patients with essential hypertension and coronary disease with or without renal artery stenosis. The frequency of renal artery stenosis in patients with essential hypertension associated with coronary artery disease was estimated as well.
Material and methods Coronary and renal arteriographies were performed at the same time in 282 patients (200 male, 82 female, age range: 26–82 years) with essential hypertension hypertension associated with coronary artery disease. The patients underwent clinical and biochemical evaluations.
Results Renal artery stenosis was diagnosed in 29 patients (10.3% of the studied group). Patients with renal artery stenosis were characterized by higher plasma concentrations: creatinine (142.0 ± 59.2 mg% vs 111.0 ± 28.1 mg%, p < 0.001), fibrinogen (399.9 ± 113.9 mg% vs 352.2 ± 103.8 mg%, p < 0.05) and homocysteine (14.1 ± 5.4 μmol/l vs 11.9 ± 4.5 μmol/l, p < 0.05) as compared to patients without renal artery stenosis. Multi-vessel disease was more frequent among patients with renal artery stenosis (72.4% vs 51.4%, p < 0.05).
Conclusions Renal artery stenosis was diagnosed in 10.3% of patients with essential hypertension and coronary artery disease. Atherosclerotic lesions in coronary arteries, especially multi-vessel disease, may indicate increased risk of coexisting renal artery stenosis. Our results indicate that fibrinogen and homocysteine, established atherosclerotic risk factors, may play a role in the development of renal artery stenosis.

Abstract

Background Renal artery stenosis of atherosclerotic origin frequently coexists with atherosclerotic lesions in other vascular beds (aorta, coronary, carotid and peripheral arteries). Several risk factors contribute to the development of coronary artery disease as well as of renal artery stenosis. The aim of the study was to evaluate atherosclerotic risk factors in patients with essential hypertension and coronary disease with or without renal artery stenosis. The frequency of renal artery stenosis in patients with essential hypertension associated with coronary artery disease was estimated as well.
Material and methods Coronary and renal arteriographies were performed at the same time in 282 patients (200 male, 82 female, age range: 26–82 years) with essential hypertension hypertension associated with coronary artery disease. The patients underwent clinical and biochemical evaluations.
Results Renal artery stenosis was diagnosed in 29 patients (10.3% of the studied group). Patients with renal artery stenosis were characterized by higher plasma concentrations: creatinine (142.0 ± 59.2 mg% vs 111.0 ± 28.1 mg%, p < 0.001), fibrinogen (399.9 ± 113.9 mg% vs 352.2 ± 103.8 mg%, p < 0.05) and homocysteine (14.1 ± 5.4 μmol/l vs 11.9 ± 4.5 μmol/l, p < 0.05) as compared to patients without renal artery stenosis. Multi-vessel disease was more frequent among patients with renal artery stenosis (72.4% vs 51.4%, p < 0.05).
Conclusions Renal artery stenosis was diagnosed in 10.3% of patients with essential hypertension and coronary artery disease. Atherosclerotic lesions in coronary arteries, especially multi-vessel disease, may indicate increased risk of coexisting renal artery stenosis. Our results indicate that fibrinogen and homocysteine, established atherosclerotic risk factors, may play a role in the development of renal artery stenosis.
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Keywords

renal artery stenosis; hypertension; coronary heart disease; risk factors for atherosclerosis

About this article
Title

Evaluation of Atherosclerotic Risk Factors in Patients with Essential Hypertension and Coronary Arteries Disease with or without Renal Artery Stenosis

Journal

Arterial Hypertension

Issue

Vol 7, No 4 (2003)

Pages

219-226

Published online

2003-09-24

Bibliographic record

Nadciśnienie tętnicze 2003;7(4):219-226.

Keywords

renal artery stenosis
hypertension
coronary heart disease
risk factors for atherosclerosis

Authors

Zofia Dzielińska
Andrzej Januszewicz
Magdalena Makowiecka-Cieśla
Jacek Kądziela
Marcin Demkow
Elżbieta Florczak
Ryszard Mielniczuk
Jadwiga Janas
Magdalena Januszewicz
Aleksander Prejbisz
Tomasz Zieliński
Dariusz Rynkun
Walerian Piotrowski
Witold Rużyłło

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