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Evaluation of Atherosclerotic Risk Factors in Patients with Essential Hypertension and Coronary Arteries Disease with or without Renal Artery Stenosis
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Abstract
Material and methods Coronary and renal arteriographies were performed at the same time in 282 patients (200 male, 82 female, age range: 26–82 years) with essential hypertension hypertension associated with coronary artery disease. The patients underwent clinical and biochemical evaluations.
Results Renal artery stenosis was diagnosed in 29 patients (10.3% of the studied group). Patients with renal artery stenosis were characterized by higher plasma concentrations: creatinine (142.0 ± 59.2 mg% vs 111.0 ± 28.1 mg%, p < 0.001), fibrinogen (399.9 ± 113.9 mg% vs 352.2 ± 103.8 mg%, p < 0.05) and homocysteine (14.1 ± 5.4 μmol/l vs 11.9 ± 4.5 μmol/l, p < 0.05) as compared to patients without renal artery stenosis. Multi-vessel disease was more frequent among patients with renal artery stenosis (72.4% vs 51.4%, p < 0.05).
Conclusions Renal artery stenosis was diagnosed in 10.3% of patients with essential hypertension and coronary artery disease. Atherosclerotic lesions in coronary arteries, especially multi-vessel disease, may indicate increased risk of coexisting renal artery stenosis. Our results indicate that fibrinogen and homocysteine, established atherosclerotic risk factors, may play a role in the development of renal artery stenosis.
Abstract
Material and methods Coronary and renal arteriographies were performed at the same time in 282 patients (200 male, 82 female, age range: 26–82 years) with essential hypertension hypertension associated with coronary artery disease. The patients underwent clinical and biochemical evaluations.
Results Renal artery stenosis was diagnosed in 29 patients (10.3% of the studied group). Patients with renal artery stenosis were characterized by higher plasma concentrations: creatinine (142.0 ± 59.2 mg% vs 111.0 ± 28.1 mg%, p < 0.001), fibrinogen (399.9 ± 113.9 mg% vs 352.2 ± 103.8 mg%, p < 0.05) and homocysteine (14.1 ± 5.4 μmol/l vs 11.9 ± 4.5 μmol/l, p < 0.05) as compared to patients without renal artery stenosis. Multi-vessel disease was more frequent among patients with renal artery stenosis (72.4% vs 51.4%, p < 0.05).
Conclusions Renal artery stenosis was diagnosed in 10.3% of patients with essential hypertension and coronary artery disease. Atherosclerotic lesions in coronary arteries, especially multi-vessel disease, may indicate increased risk of coexisting renal artery stenosis. Our results indicate that fibrinogen and homocysteine, established atherosclerotic risk factors, may play a role in the development of renal artery stenosis.
Keywords
renal artery stenosis; hypertension; coronary heart disease; risk factors for atherosclerosis
About this articleTitle
Evaluation of Atherosclerotic Risk Factors in Patients with Essential Hypertension and Coronary Arteries Disease with or without Renal Artery Stenosis
Journal
Issue
Article type
Original paper
Pages
219-226
Published online
2003-09-24
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710
Article views/downloads
1144
Bibliographic record
Nadciśnienie tętnicze 2003;7(4):219-226.
Keywords
renal artery stenosis
hypertension
coronary heart disease
risk factors for atherosclerosis
Authors
Zofia Dzielińska
Andrzej Januszewicz
Magdalena Makowiecka-Cieśla
Jacek Kądziela
Marcin Demkow
Elżbieta Florczak
Ryszard Mielniczuk
Jadwiga Janas
Magdalena Januszewicz
Aleksander Prejbisz
Tomasz Zieliński
Dariusz Rynkun
Walerian Piotrowski
Witold Rużyłło