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Effect of hormone replacement therapy on renal excretion of uric acid and prevalance of thiazide induced hyperuricemia in postmenopausal hypertensive women
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Abstract
Material and methods Fifty four hypertensive postmenopausal women aged 58.4 ± 5.1 years, receiving HRT (n = 24) or without HRT (n = 30) were compared with 30 normotensive postmenopausal women. All hypertensive patients were treated with thiazide diuretic. The creatinine and uric acid serum level and renal excretion were estimated after 4–6 months of treatment. Based on this data uric acid clearance and its fractional excretion were calculated.
Results The serum uric acid levels in women without HRT were significantly higher and uric acid clearance and fractional excretion significantly lower than in other groups. Negative correlations between serum uric acid levels and its clearance have been found in all groups. Chronic thiazide therapy of hypertension did not alter serum uric acid concentrations and its renal excretion only in HRT group, whereas in women without HRT serum uric acid levels increased significantly from 6.01 ± 1.21 to 7.12 ± 1.43 mg/dl and both uric acid clearance and its fractional excretion decreased significantly from 8.41 ± 1.89 to 6.57 ± 1.73 ml/min and from 8.02 ± 2.15 to 6.23 ± 1.88% respectively.
Conclusions 1. Both hypertension and menopause had influence on uric acid renal excretion and its serum concentration. 2. Hormone replacement therapy decreases plasma uric acid in postmenopausal women. 3. Hormone replacement therapy tends to prevent hyperuricemia during thiazide treatment of hypertension.
Abstract
Material and methods Fifty four hypertensive postmenopausal women aged 58.4 ± 5.1 years, receiving HRT (n = 24) or without HRT (n = 30) were compared with 30 normotensive postmenopausal women. All hypertensive patients were treated with thiazide diuretic. The creatinine and uric acid serum level and renal excretion were estimated after 4–6 months of treatment. Based on this data uric acid clearance and its fractional excretion were calculated.
Results The serum uric acid levels in women without HRT were significantly higher and uric acid clearance and fractional excretion significantly lower than in other groups. Negative correlations between serum uric acid levels and its clearance have been found in all groups. Chronic thiazide therapy of hypertension did not alter serum uric acid concentrations and its renal excretion only in HRT group, whereas in women without HRT serum uric acid levels increased significantly from 6.01 ± 1.21 to 7.12 ± 1.43 mg/dl and both uric acid clearance and its fractional excretion decreased significantly from 8.41 ± 1.89 to 6.57 ± 1.73 ml/min and from 8.02 ± 2.15 to 6.23 ± 1.88% respectively.
Conclusions 1. Both hypertension and menopause had influence on uric acid renal excretion and its serum concentration. 2. Hormone replacement therapy decreases plasma uric acid in postmenopausal women. 3. Hormone replacement therapy tends to prevent hyperuricemia during thiazide treatment of hypertension.
Keywords
hypertension; hyperuricemia; hormone replacement therapy
Title
Effect of hormone replacement therapy on renal excretion of uric acid and prevalance of thiazide induced hyperuricemia in postmenopausal hypertensive women
Journal
Issue
Article type
Original paper
Pages
25-32
Published online
2004-01-23
Page views
939
Article views/downloads
1409
Bibliographic record
Nadciśnienie tętnicze 2004;8(1):25-32.
Keywords
hypertension
hyperuricemia
hormone replacement therapy
Authors
Anna Posadzy-Małaczyńska
Andrzej Tykarski
Paweł Łopatka
Jerzy Głuszek