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Vol 8, No 2 (2004)
REVIEV
Published online: 2004-04-06
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G protein β3 subunit gene polymorphism and arterial blood pressure, indices of arterial structure and function

Agnieszka Olszanecka, Kalina Kawecka-Jaszcz, Katarzyna Stolarz, Wojciech Lubaszewski, Barbara Wizner, Tomasz Grodzicki, Beata Kieć-Wilk, Aldona Dembińska-Kieć
Nadciśnienie tętnicze 2004;8(2):119-131.

open access

Vol 8, No 2 (2004)
REVIEV
Published online: 2004-04-06

Abstract

There is some evidence that GNB3 C825T may be associated with metabolic syndrome phenotypes including essential hypertension. We investigated whether blood pressure or indices of arterial structure and function are associated with GNB3 polymorphism in Polish population.
We studied 86 nuclear families - 142 parents (age 50.3 ± 5.0 years) and 184 offspring (age 24.0 ± 4.7 years) enrolled in the population-based study in Cracow. Each subject underwent the 24-hr ambulatory blood pressure monitoring (SpaceLabs 90207), carotid ultrasound and pulse wave velocity measurements. Genotypes were determined by allele-specific hybridization.
Genotype frequencies (42.3% for CC, 50.9% for CT and 6.8% for TT) did not deviate from Hardy-Weinberg equilibrium (p = 0.21). Among parents but not among offspring 24-hour, day-time and night-time systolic blood pressures were 5-7 mm Hg higher in TT homozygotes then in C allele carriers (p = 0.04). Similarly, in parents TT homozygotes compared to C-allele carriers had increased pulse wave velocity (11.9 ± 2.2 vs. 10.4 ± 1.5 m/s). No differences in features influenced by gentotype were found in the offspring. In our study we found that the influence of GNB3 C825T polymorphism on blood pressure shows different pattern in the two generations. It is associated with higher systolic blood pressure and higher pulse wave velocity only in parent generation. This observation supports the thesis about recessive model of phenotypic effect of GNB3 polymorphism, which can be detected only in older age-generation group.

Abstract

There is some evidence that GNB3 C825T may be associated with metabolic syndrome phenotypes including essential hypertension. We investigated whether blood pressure or indices of arterial structure and function are associated with GNB3 polymorphism in Polish population.
We studied 86 nuclear families - 142 parents (age 50.3 ± 5.0 years) and 184 offspring (age 24.0 ± 4.7 years) enrolled in the population-based study in Cracow. Each subject underwent the 24-hr ambulatory blood pressure monitoring (SpaceLabs 90207), carotid ultrasound and pulse wave velocity measurements. Genotypes were determined by allele-specific hybridization.
Genotype frequencies (42.3% for CC, 50.9% for CT and 6.8% for TT) did not deviate from Hardy-Weinberg equilibrium (p = 0.21). Among parents but not among offspring 24-hour, day-time and night-time systolic blood pressures were 5-7 mm Hg higher in TT homozygotes then in C allele carriers (p = 0.04). Similarly, in parents TT homozygotes compared to C-allele carriers had increased pulse wave velocity (11.9 ± 2.2 vs. 10.4 ± 1.5 m/s). No differences in features influenced by gentotype were found in the offspring. In our study we found that the influence of GNB3 C825T polymorphism on blood pressure shows different pattern in the two generations. It is associated with higher systolic blood pressure and higher pulse wave velocity only in parent generation. This observation supports the thesis about recessive model of phenotypic effect of GNB3 polymorphism, which can be detected only in older age-generation group.
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Keywords

hypertension; genetics; GNB3; arterial compliance

About this article
Title

G protein β3 subunit gene polymorphism and arterial blood pressure, indices of arterial structure and function

Journal

Arterial Hypertension

Issue

Vol 8, No 2 (2004)

Pages

119-131

Published online

2004-04-06

Bibliographic record

Nadciśnienie tętnicze 2004;8(2):119-131.

Keywords

hypertension
genetics
GNB3
arterial compliance

Authors

Agnieszka Olszanecka
Kalina Kawecka-Jaszcz
Katarzyna Stolarz
Wojciech Lubaszewski
Barbara Wizner
Tomasz Grodzicki
Beata Kieć-Wilk
Aldona Dembińska-Kieć

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