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Insulin resistance, endothelin, microalbuminuria - their interrelations in patients with arterial hypertension
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Abstract
Material and methods In 20 non-obese patients with arterial hypertension insulin resistance was measured by hyperinsulinemic euglycaemic clamp technique. The insulin resistance is expressed as the reciprocal of glucose disposal rate - M. The ET and 24-h UAE were evaluated by radioimmunoassay methods.
Results Insulin resistance was diagnosed in 35% of examined population. The mean value of glucose disposal rate M-value was 273.03 ± 44.65 mg/(m2 x min). The mean value of ET was 25.59 ± 8.00 pg/ml, 24-h UAE was 25.92 ± 18.19 mg. We found significant correlation between M and ET (r = –0.6486; p < 0.01) between M and UAE (r = –0.7110; p < 0.001) and ET and UAE (r = 0.6566; p < 0.01).
Conclusion Insulin resistance was observed in 35% of nonobese patients with arterial hypertension. Significant correlation between degree of hypertension and intensity of insulin resistance was found. In hypertensive subjects with BMI in normal range significant correlations between insulin resistance and serum ET concentration and magnitude of UAE were found. The correlations found in our study suggest that non-obese patients with arterial hypertension demonstrated endothelial function defect which is correlated with many metabolic disorders.
Abstract
Material and methods In 20 non-obese patients with arterial hypertension insulin resistance was measured by hyperinsulinemic euglycaemic clamp technique. The insulin resistance is expressed as the reciprocal of glucose disposal rate - M. The ET and 24-h UAE were evaluated by radioimmunoassay methods.
Results Insulin resistance was diagnosed in 35% of examined population. The mean value of glucose disposal rate M-value was 273.03 ± 44.65 mg/(m2 x min). The mean value of ET was 25.59 ± 8.00 pg/ml, 24-h UAE was 25.92 ± 18.19 mg. We found significant correlation between M and ET (r = –0.6486; p < 0.01) between M and UAE (r = –0.7110; p < 0.001) and ET and UAE (r = 0.6566; p < 0.01).
Conclusion Insulin resistance was observed in 35% of nonobese patients with arterial hypertension. Significant correlation between degree of hypertension and intensity of insulin resistance was found. In hypertensive subjects with BMI in normal range significant correlations between insulin resistance and serum ET concentration and magnitude of UAE were found. The correlations found in our study suggest that non-obese patients with arterial hypertension demonstrated endothelial function defect which is correlated with many metabolic disorders.
Keywords
arterial hypertension; insulin resistance; endothelin; microalbuminuria


Title
Insulin resistance, endothelin, microalbuminuria - their interrelations in patients with arterial hypertension
Journal
Issue
Article type
Original paper
Pages
103-108
Published online
2004-04-06
Page views
4620
Article views/downloads
1088
Bibliographic record
Nadciśnienie tętnicze 2004;8(2):103-108.
Keywords
arterial hypertension
insulin resistance
endothelin
microalbuminuria
Authors
Anna Boruczkowska
Danuta Pupek-Musialik
Jerzy Głuszek