open access

Vol 8, No 2 (2004)
Original paper
Published online: 2004-04-06
Get Citation

Left ventricular mass in patients with primary aldosteronism after etiologic treatment

Agnieszka Kuch-Wocial, Piotr Pruszczyk, Maciej Kostrubiec, Katarzyna Ślubowska, Jacek Lewandowski, Tomasz Pasierski, Włodzimierz Januszewicz, Andrzej Januszewicz, Bożena Wocial, Hanna Ignatowska
Nadciśnienie tętnicze 2004;8(2):89-95.

open access

Vol 8, No 2 (2004)
Prace oryginalne
Published online: 2004-04-06

Abstract

Background Primary aldosteronism is an example of common influence of humoral factors like aldosterone, adrenaline, dopamine and hemodynamic factors - volume dependency and vascular resistance - on the left ventricular mass. The aim of the study was the assessment of left ventricular mass regression in patients with APA and IHA after operation and spironolactone treatment in follow up period from 6 to 12 mth’s.
Material and methods The study included 46 pts. with primary aldosteronism: 32 pts. with APA (28 F, 4 M with mean age 48,6 ± 4,1 yrs.) and 14 pts. with IHA (13 F, 1 M with mean age 48,5 ± 6,5 yrs.).
Blood pressure was determined by 24-hour monitoring, echocardiographic parameters were measured according to ASE. Aldosterone plasma concentration and plasma renin activity were determinated by radioimmunologic methods.
Results We observed statistically significant decrease of LVMI in both groups of pts. In IHA left ventricular hypertrophy (LVH) regression (124,76 ± 33,4 g/m2 vs. 106,10 ± 31,5 g/m2) resulted from decreased left ventricular wall thickness, with no changes in left ventricular diastolic dimension. Of note there were no significant changes in mean diastolic and systolic blood pressure. In APA pts. LVH regression (125 ± 25 /m2 vs. 98 ± 24 g/m2) was a consequence of decreased wall thickness and left ventricular diameter. In this group we observed statistically significant decrease of mean systolic blood pressure.
Conclusion 1. Left ventricular mass regression was observed both in pts. with APA and IHA after medical or surgical treatment. 2. Left ventricular mass regression in pts. with IHA without concomitant significant hypotensive effect suggests aldosterone influence on LVH. 3. Adrenalectomy in pts., with APA leads to more effective blood pressure lowering than spironolactone therapy in pts. with IHA.

Abstract

Background Primary aldosteronism is an example of common influence of humoral factors like aldosterone, adrenaline, dopamine and hemodynamic factors - volume dependency and vascular resistance - on the left ventricular mass. The aim of the study was the assessment of left ventricular mass regression in patients with APA and IHA after operation and spironolactone treatment in follow up period from 6 to 12 mth’s.
Material and methods The study included 46 pts. with primary aldosteronism: 32 pts. with APA (28 F, 4 M with mean age 48,6 ± 4,1 yrs.) and 14 pts. with IHA (13 F, 1 M with mean age 48,5 ± 6,5 yrs.).
Blood pressure was determined by 24-hour monitoring, echocardiographic parameters were measured according to ASE. Aldosterone plasma concentration and plasma renin activity were determinated by radioimmunologic methods.
Results We observed statistically significant decrease of LVMI in both groups of pts. In IHA left ventricular hypertrophy (LVH) regression (124,76 ± 33,4 g/m2 vs. 106,10 ± 31,5 g/m2) resulted from decreased left ventricular wall thickness, with no changes in left ventricular diastolic dimension. Of note there were no significant changes in mean diastolic and systolic blood pressure. In APA pts. LVH regression (125 ± 25 /m2 vs. 98 ± 24 g/m2) was a consequence of decreased wall thickness and left ventricular diameter. In this group we observed statistically significant decrease of mean systolic blood pressure.
Conclusion 1. Left ventricular mass regression was observed both in pts. with APA and IHA after medical or surgical treatment. 2. Left ventricular mass regression in pts. with IHA without concomitant significant hypotensive effect suggests aldosterone influence on LVH. 3. Adrenalectomy in pts., with APA leads to more effective blood pressure lowering than spironolactone therapy in pts. with IHA.
Get Citation

Keywords

primary aldosteronism; left ventricular hypertrophy; aldosterone; plasma renin activity

About this article
Title

Left ventricular mass in patients with primary aldosteronism after etiologic treatment

Journal

Arterial Hypertension

Issue

Vol 8, No 2 (2004)

Article type

Original paper

Pages

89-95

Published online

2004-04-06

Page views

743

Article views/downloads

1253

Bibliographic record

Nadciśnienie tętnicze 2004;8(2):89-95.

Keywords

primary aldosteronism
left ventricular hypertrophy
aldosterone
plasma renin activity

Authors

Agnieszka Kuch-Wocial
Piotr Pruszczyk
Maciej Kostrubiec
Katarzyna Ślubowska
Jacek Lewandowski
Tomasz Pasierski
Włodzimierz Januszewicz
Andrzej Januszewicz
Bożena Wocial
Hanna Ignatowska

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., Grupa Via Medica, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl