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Left ventricular mass in patients with primary aldosteronism after etiologic treatment
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Abstract
Material and methods The study included 46 pts. with primary aldosteronism: 32 pts. with APA (28 F, 4 M with mean age 48,6 ± 4,1 yrs.) and 14 pts. with IHA (13 F, 1 M with mean age 48,5 ± 6,5 yrs.).
Blood pressure was determined by 24-hour monitoring, echocardiographic parameters were measured according to ASE. Aldosterone plasma concentration and plasma renin activity were determinated by radioimmunologic methods.
Results We observed statistically significant decrease of LVMI in both groups of pts. In IHA left ventricular hypertrophy (LVH) regression (124,76 ± 33,4 g/m2 vs. 106,10 ± 31,5 g/m2) resulted from decreased left ventricular wall thickness, with no changes in left ventricular diastolic dimension. Of note there were no significant changes in mean diastolic and systolic blood pressure. In APA pts. LVH regression (125 ± 25 /m2 vs. 98 ± 24 g/m2) was a consequence of decreased wall thickness and left ventricular diameter. In this group we observed statistically significant decrease of mean systolic blood pressure.
Conclusion 1. Left ventricular mass regression was observed both in pts. with APA and IHA after medical or surgical treatment. 2. Left ventricular mass regression in pts. with IHA without concomitant significant hypotensive effect suggests aldosterone influence on LVH. 3. Adrenalectomy in pts., with APA leads to more effective blood pressure lowering than spironolactone therapy in pts. with IHA.
Abstract
Material and methods The study included 46 pts. with primary aldosteronism: 32 pts. with APA (28 F, 4 M with mean age 48,6 ± 4,1 yrs.) and 14 pts. with IHA (13 F, 1 M with mean age 48,5 ± 6,5 yrs.).
Blood pressure was determined by 24-hour monitoring, echocardiographic parameters were measured according to ASE. Aldosterone plasma concentration and plasma renin activity were determinated by radioimmunologic methods.
Results We observed statistically significant decrease of LVMI in both groups of pts. In IHA left ventricular hypertrophy (LVH) regression (124,76 ± 33,4 g/m2 vs. 106,10 ± 31,5 g/m2) resulted from decreased left ventricular wall thickness, with no changes in left ventricular diastolic dimension. Of note there were no significant changes in mean diastolic and systolic blood pressure. In APA pts. LVH regression (125 ± 25 /m2 vs. 98 ± 24 g/m2) was a consequence of decreased wall thickness and left ventricular diameter. In this group we observed statistically significant decrease of mean systolic blood pressure.
Conclusion 1. Left ventricular mass regression was observed both in pts. with APA and IHA after medical or surgical treatment. 2. Left ventricular mass regression in pts. with IHA without concomitant significant hypotensive effect suggests aldosterone influence on LVH. 3. Adrenalectomy in pts., with APA leads to more effective blood pressure lowering than spironolactone therapy in pts. with IHA.
Keywords
primary aldosteronism; left ventricular hypertrophy; aldosterone; plasma renin activity
Title
Left ventricular mass in patients with primary aldosteronism after etiologic treatment
Journal
Issue
Article type
Original paper
Pages
89-95
Published online
2004-04-06
Page views
743
Article views/downloads
1253
Bibliographic record
Nadciśnienie tętnicze 2004;8(2):89-95.
Keywords
primary aldosteronism
left ventricular hypertrophy
aldosterone
plasma renin activity
Authors
Agnieszka Kuch-Wocial
Piotr Pruszczyk
Maciej Kostrubiec
Katarzyna Ślubowska
Jacek Lewandowski
Tomasz Pasierski
Włodzimierz Januszewicz
Andrzej Januszewicz
Bożena Wocial
Hanna Ignatowska