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Sodium nitroprusside - the role in rapid reduction of blood pressure. Current drug analysis
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Abstract
SNP appears useful for induction of hipotension during surgery and for treatment of hipertensive emergencies from all causes, although continuance for more than a few days is probably dangerous. It is hoped that future studies will establish the maximum dose of nitroprusside that can safely be metabolized in a 24 hour period and may indicate that cofactors of rhodanase such as thiosulfate or cobalamins such as hydroxocobalamin can be administered with nitroprusside to prevent cyanide poisoning.
Despite its toxicity, SNP is popular because it is often the most effective drug in some difficult circumstances.
Abstract
SNP appears useful for induction of hipotension during surgery and for treatment of hipertensive emergencies from all causes, although continuance for more than a few days is probably dangerous. It is hoped that future studies will establish the maximum dose of nitroprusside that can safely be metabolized in a 24 hour period and may indicate that cofactors of rhodanase such as thiosulfate or cobalamins such as hydroxocobalamin can be administered with nitroprusside to prevent cyanide poisoning.
Despite its toxicity, SNP is popular because it is often the most effective drug in some difficult circumstances.
Keywords
hypertension; sodium nitroprusside; cyanide poisoning
Title
Sodium nitroprusside - the role in rapid reduction of blood pressure. Current drug analysis
Journal
Issue
Article type
Review paper
Pages
185-190
Published online
2004-06-04
Page views
6330
Article views/downloads
10599
Bibliographic record
Nadciśnienie tętnicze 2004;8(3):185-190.
Keywords
hypertension
sodium nitroprusside
cyanide poisoning
Authors
Agnieszka Trajder
Alicja Abramczyk