open access

Vol 8, No 3 (2004)
Artykuły redakcyjne
Published online: 2004-06-04
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Treatment of arterial hypertension in patients with chronic pulmonary diseases

Andrzej Tykarski, Katarzyna Kostka-Jeziorny
Nadciśnienie tętnicze 2004;8(3):147-157.

open access

Vol 8, No 3 (2004)
Artykuły redakcyjne
Published online: 2004-06-04

Abstract

This article presents a review of English-language literature pertaining to drug therapy for systemic high blood pressure in patients with pulmonary diseases. The concomitant presence of arterial hypertension and chronic airway obstruction (asthma or COPD) is not unusual. Hypertension is the most common comorbid disease in COPD patients. The antihypertensive agents reviewed include: diuretics, calcium antagonists, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, β-adrenergic blocking agents, α-blockers and other classes. A wide variety of antihypertensive drugs with different mechanism of action is now available. Many antihypertensive drugs can affect airway function, the treatment of hypertension in patients with airway dysfunction is complex. For example, β-adrenergic blocking agents can cause bronchoconstriction, because β2-receptors are widely distributed in airway smooth muscles. Beta-blockers can cause severe bronchoconstriction even in subjects with mild asthma. Angiotensin-converting enzyme inhibitors may cause cough and excerbate or even induce asthma; however angiotensin II type I antagonists do not cause caugh. So it seems that not all antihypertensive drugs are equally safe in patients with systemic arterial hypertension and concurrent airway dysfunction. Based on the reviewed literature, we suggest that calcium blockers or angiotensin II receptor antagonists are the first choice drugs for these patients.

Abstract

This article presents a review of English-language literature pertaining to drug therapy for systemic high blood pressure in patients with pulmonary diseases. The concomitant presence of arterial hypertension and chronic airway obstruction (asthma or COPD) is not unusual. Hypertension is the most common comorbid disease in COPD patients. The antihypertensive agents reviewed include: diuretics, calcium antagonists, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, β-adrenergic blocking agents, α-blockers and other classes. A wide variety of antihypertensive drugs with different mechanism of action is now available. Many antihypertensive drugs can affect airway function, the treatment of hypertension in patients with airway dysfunction is complex. For example, β-adrenergic blocking agents can cause bronchoconstriction, because β2-receptors are widely distributed in airway smooth muscles. Beta-blockers can cause severe bronchoconstriction even in subjects with mild asthma. Angiotensin-converting enzyme inhibitors may cause cough and excerbate or even induce asthma; however angiotensin II type I antagonists do not cause caugh. So it seems that not all antihypertensive drugs are equally safe in patients with systemic arterial hypertension and concurrent airway dysfunction. Based on the reviewed literature, we suggest that calcium blockers or angiotensin II receptor antagonists are the first choice drugs for these patients.
Get Citation

Keywords

pulmonary disease; antihypertension drugs; COPD; asthma; arterial hypertension

About this article
Title

Treatment of arterial hypertension in patients with chronic pulmonary diseases

Journal

Arterial Hypertension

Issue

Vol 8, No 3 (2004)

Pages

147-157

Published online

2004-06-04

Bibliographic record

Nadciśnienie tętnicze 2004;8(3):147-157.

Keywords

pulmonary disease
antihypertension drugs
COPD
asthma
arterial hypertension

Authors

Andrzej Tykarski
Katarzyna Kostka-Jeziorny

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