Vol 8, No 4 (2004)
Review paper
Published online: 2004-07-22
Dihydropyridine calcium antagonists - old and new indications
Tomasz Grodzicki
Nadciśnienie tętnicze 2004;8(4):273-277.
Vol 8, No 4 (2004)
REVIEV
Published online: 2004-07-22
Abstract
Dihydropyridine calcium antagonists have been used in clinical practice for over 20 years now. The use of short-acting dihydropyridine derivatives was associated with too
abrupt blood pressure lowering and adrenergic hyperactivity with all the unfavourable sequelae. They have been
replaced by long-acting derivatives, free of these effects. During the last decade, safety and efficacy of these agents were proven in a number of large clinical trials, which
included many thousand patients. In this review the most prominent trials are presented. Also, the indications for dihydropyridine calcium antagonists in special populations
(e.g. patients with comorbid renal disease or heart failure, the elderly, and patients receiving non-steroid antiinflammatory drugs) were briefly summarized.
Abstract
Dihydropyridine calcium antagonists have been used in clinical practice for over 20 years now. The use of short-acting dihydropyridine derivatives was associated with too
abrupt blood pressure lowering and adrenergic hyperactivity with all the unfavourable sequelae. They have been
replaced by long-acting derivatives, free of these effects. During the last decade, safety and efficacy of these agents were proven in a number of large clinical trials, which
included many thousand patients. In this review the most prominent trials are presented. Also, the indications for dihydropyridine calcium antagonists in special populations
(e.g. patients with comorbid renal disease or heart failure, the elderly, and patients receiving non-steroid antiinflammatory drugs) were briefly summarized.
Keywords
calcium antagonists; dihydropyridines; hypertension treatment
Title
Dihydropyridine calcium antagonists - old and new indications
Journal
Arterial Hypertension
Issue
Vol 8, No 4 (2004)
Article type
Review paper
Pages
273-277
Published online
2004-07-22
Page views
884
Article views/downloads
1980
Bibliographic record
Nadciśnienie tętnicze 2004;8(4):273-277.
Keywords
calcium antagonists
dihydropyridines
hypertension treatment