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Evaluation of urine endothelin-1 (ET-1) level in patients with essential hypertension
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Abstract
The aim of our study was to estimate the diagnostic value of plasma and urine ET-1 concentration measurement in hypertensive patients.
Material and methods Two groups were studied: group I - 26 hypertensive patients (systolic blood pressure: Me 158 ± 9 mm Hg, diastolic blood pressure: Me 95 ± 5 mm Hg) and group II - 10 healthy volunteers (systolic blood pressure: 120 ± 4,00 mm Hg, diastolic blood pressure: Me 68 ± 4,50 mm Hg). In classifying subjects ET-1 concentrations were measured by radioimmunoassay in: a) plasma, b) 24-hour urine collection.
Results 1. Plasma ET-1 concentration did not differ between the two groups (Me ± S group I: 37,4 ± 11,4 vs. group II: 33,3 ± 6,66 pg/ml, NS). 2. Urine ET-1 excretion assessed in 24-hour urine collection were significantly higher in I group than in II group (Me ± S group I: 106,11 ± 49,74 vs. group II: 11,3 ± 6,65 ng/g urinary creatinine, p = 0.00001).
Conclusions We may suspect that evaluation of ET-1 concentration in 24-hour urine collection may be more exact than evaluation of this peptide in plasma. This observation may prove the importance of ET-1 in hypertension.
Abstract
The aim of our study was to estimate the diagnostic value of plasma and urine ET-1 concentration measurement in hypertensive patients.
Material and methods Two groups were studied: group I - 26 hypertensive patients (systolic blood pressure: Me 158 ± 9 mm Hg, diastolic blood pressure: Me 95 ± 5 mm Hg) and group II - 10 healthy volunteers (systolic blood pressure: 120 ± 4,00 mm Hg, diastolic blood pressure: Me 68 ± 4,50 mm Hg). In classifying subjects ET-1 concentrations were measured by radioimmunoassay in: a) plasma, b) 24-hour urine collection.
Results 1. Plasma ET-1 concentration did not differ between the two groups (Me ± S group I: 37,4 ± 11,4 vs. group II: 33,3 ± 6,66 pg/ml, NS). 2. Urine ET-1 excretion assessed in 24-hour urine collection were significantly higher in I group than in II group (Me ± S group I: 106,11 ± 49,74 vs. group II: 11,3 ± 6,65 ng/g urinary creatinine, p = 0.00001).
Conclusions We may suspect that evaluation of ET-1 concentration in 24-hour urine collection may be more exact than evaluation of this peptide in plasma. This observation may prove the importance of ET-1 in hypertension.
Keywords
plasma endothelin-1; essential hypertension; urine endothelin-1
Title
Evaluation of urine endothelin-1 (ET-1) level in patients with essential hypertension
Journal
Issue
Article type
Original paper
Pages
239-243
Published online
2004-07-22
Page views
707
Article views/downloads
972
Bibliographic record
Nadciśnienie tętnicze 2004;8(4):239-243.
Keywords
plasma endothelin-1
essential hypertension
urine endothelin-1
Authors
Teresa Kosicka
Hanna Kara-Perz
Jerzy Głuszek