open access

Vol 8, No 5 (2004)
Prace oryginalne
Published online: 2004-11-15
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The effect of short and long-term trandolapril treatment on blood pressure and endothelin-1 plasma concentration in young, hypertensive patients

Wiesław Bryl, Anna Miczke, Paweł Bogdański, Magdalena Kujawska-Łuczak, Maciej Cymerys, Danuta Pupek-Musialik, Olga Trojnarska
Nadciśnienie tętnicze 2004;8(5):347-354.

open access

Vol 8, No 5 (2004)
Prace oryginalne
Published online: 2004-11-15

Abstract

Background Endothelin is the strongest endogenic substance causing vasoconstriction.
Materials and methods The aim of the study was an assessment of the influence of a given angiotensin converting enzyme inhibitor therapy on blood pressure and endothelin-1 concentration in young population with mild to moderate hypertension.
There were 2 steps of this study. Into the first step (6 weeks) 19 young patients (14 men and 5 women) aged 16-19 were enrolled. The average age of this population was 17.6 ± 1.4 years. The patients were untreated or there was a 7 days wash-out period. Before enrolling and after 6 weeks of trandolapril therapy (2 mg/day) blood pressure and plasma endothelin-1 concentration were measured. Endothelin was measured by radioimmunoassay. In the second step of the trial blood pressure and endothelin-1 were assessed after 6 months of trandolapril therapy (2 mg/day).
Results In analysed group after 6 weeks of trandolapril therapy there was a significant both systolic and diastolic blood pressure lowering. The average systolic blood pressure values were reduced from 142.6 ± 9.7 mm Hg to 129.3 ± 8.4 mm Hg (p < 0.0003), the average diastolic blood pressure were reduced from 85.7 ± 6.9 mm Hg to 79.8 ± 8.6 mm Hg (p < 0.01). The average endothelin-1 concentration was: before therapy 9.33 ± 1.9 fmol/ml, after therapy 8.96 ± 2.2 fmol/ml (this lowering was not statistically significant). After 6 months of treatment the blood pressure reduction was on the same level, but there was a significant reduction of endothelin-1 plasma concentration (initial concentration - 9.33 ± 1.9 fmol/ml, final concentration - 7.49 ± 2.7 fmol/ml, p < 0.05).
Conclusion Trandolapril therapy, both short-time (6 weeks) and long-time (6 months) gave a significant blood pressure reduction, whereas only a long-time treatment caused a significant plasma endothelin-1 concentration reduction. The therapy did not influence on lipid.

Abstract

Background Endothelin is the strongest endogenic substance causing vasoconstriction.
Materials and methods The aim of the study was an assessment of the influence of a given angiotensin converting enzyme inhibitor therapy on blood pressure and endothelin-1 concentration in young population with mild to moderate hypertension.
There were 2 steps of this study. Into the first step (6 weeks) 19 young patients (14 men and 5 women) aged 16-19 were enrolled. The average age of this population was 17.6 ± 1.4 years. The patients were untreated or there was a 7 days wash-out period. Before enrolling and after 6 weeks of trandolapril therapy (2 mg/day) blood pressure and plasma endothelin-1 concentration were measured. Endothelin was measured by radioimmunoassay. In the second step of the trial blood pressure and endothelin-1 were assessed after 6 months of trandolapril therapy (2 mg/day).
Results In analysed group after 6 weeks of trandolapril therapy there was a significant both systolic and diastolic blood pressure lowering. The average systolic blood pressure values were reduced from 142.6 ± 9.7 mm Hg to 129.3 ± 8.4 mm Hg (p < 0.0003), the average diastolic blood pressure were reduced from 85.7 ± 6.9 mm Hg to 79.8 ± 8.6 mm Hg (p < 0.01). The average endothelin-1 concentration was: before therapy 9.33 ± 1.9 fmol/ml, after therapy 8.96 ± 2.2 fmol/ml (this lowering was not statistically significant). After 6 months of treatment the blood pressure reduction was on the same level, but there was a significant reduction of endothelin-1 plasma concentration (initial concentration - 9.33 ± 1.9 fmol/ml, final concentration - 7.49 ± 2.7 fmol/ml, p < 0.05).
Conclusion Trandolapril therapy, both short-time (6 weeks) and long-time (6 months) gave a significant blood pressure reduction, whereas only a long-time treatment caused a significant plasma endothelin-1 concentration reduction. The therapy did not influence on lipid.
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Keywords

hypertension; endothelin-1; young hypertensives; ACE-I therapy

About this article
Title

The effect of short and long-term trandolapril treatment on blood pressure and endothelin-1 plasma concentration in young, hypertensive patients

Journal

Arterial Hypertension

Issue

Vol 8, No 5 (2004)

Pages

347-354

Published online

2004-11-15

Bibliographic record

Nadciśnienie tętnicze 2004;8(5):347-354.

Keywords

hypertension
endothelin-1
young hypertensives
ACE-I therapy

Authors

Wiesław Bryl
Anna Miczke
Paweł Bogdański
Magdalena Kujawska-Łuczak
Maciej Cymerys
Danuta Pupek-Musialik
Olga Trojnarska

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