open access

Vol 8, No 6 (2004)
REVIEV
Published online: 2004-12-14
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The role of oxidative stress in the pathogenesis of arterial hypertension

Helena Martynowicz, Anna Skoczyńska, Michał Silber, Ryszard Andrzejak
Nadciśnienie tętnicze 2004;8(6):431-438.

open access

Vol 8, No 6 (2004)
REVIEV
Published online: 2004-12-14

Abstract

Free radicals, including superoxide anion, play an essential role in the pathogenesis of the diseases of cardiovascular system. NADPH oxidase, xantine oxidase, nitric oxide synthase and cyclooxygenase are main sources of the superoxide. Superoxide anion reduces availability of nitric oxide by converting it to peroxynitrite (ONOO). Imbalance between free radicals and antioxidants leads to the endothelial dysfunction and hypertension. There is no data from prospective clinical trials that antioxidants have a hypotensive activity until now. Despite of this, introducing antioxidant rich diet and drugs with antioxidant activity in the hypertensive therapy seems to be beneficial.

Abstract

Free radicals, including superoxide anion, play an essential role in the pathogenesis of the diseases of cardiovascular system. NADPH oxidase, xantine oxidase, nitric oxide synthase and cyclooxygenase are main sources of the superoxide. Superoxide anion reduces availability of nitric oxide by converting it to peroxynitrite (ONOO). Imbalance between free radicals and antioxidants leads to the endothelial dysfunction and hypertension. There is no data from prospective clinical trials that antioxidants have a hypotensive activity until now. Despite of this, introducing antioxidant rich diet and drugs with antioxidant activity in the hypertensive therapy seems to be beneficial.
Get Citation

Keywords

arterial hypertension; oxidative stress; superoxide anion; antioxidants

About this article
Title

The role of oxidative stress in the pathogenesis of arterial hypertension

Journal

Arterial Hypertension

Issue

Vol 8, No 6 (2004)

Pages

431-438

Published online

2004-12-14

Bibliographic record

Nadciśnienie tętnicze 2004;8(6):431-438.

Keywords

arterial hypertension
oxidative stress
superoxide anion
antioxidants

Authors

Helena Martynowicz
Anna Skoczyńska
Michał Silber
Ryszard Andrzejak

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