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The relationship between left ventricular diastolic function and arterial stiffness in normotensive males
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Abstract
The aim of this study was to evaluate the relationship between left ventricular diastolic function and arterial stiffness in normotensive males.
Material and methods We examined 26 healthy male subjects aged 43 ± 8 years (BMI 26.9 ± 4.2 kg/m2, 24h-SBP 127 ± 8 mm Hg, 24h-DBP 80 ± 5 mm Hg, 24h-HR 76 ± 8 bpm). The carotid-femoral pulse wave velocity (PWV) was used as a measure of arterial stiffness. Doppler echocardiography was performed using ALOKA 5000 machine equipped with 2.5–3.5 MHz transducer. LV diastolic function was described by the peak of early (E) and late (A) transmitral flow velocity, deceleration time (DT) of E and slope of E peak deceleration (Dec E).
Results Significant correlation coefficients were found between PWV and parameters of left ventricular diastolic function (PWV vs. E r = –0.531, p = 0.006; PWV vs. E/A r = –0.478, p = 0.016). The analysis of relationship between PWV and DecE revealed r = –0.353, p = 0.083. We did not observe any significant correlation between PWV and parameters of left ventricular structure (EF %, LVMI /m2), as well.
Conclusion Our study revealed significant relationship between arterial stiffness and left ventricular diastolic function in normotensive males. Therefore, increased arterial stiffness may serve as an early evidence of impaired left ventricular diastolic function. This relationship revealed in healthy subjects may indicate that alterations in heart and arterial function may be parallel.
Abstract
The aim of this study was to evaluate the relationship between left ventricular diastolic function and arterial stiffness in normotensive males.
Material and methods We examined 26 healthy male subjects aged 43 ± 8 years (BMI 26.9 ± 4.2 kg/m2, 24h-SBP 127 ± 8 mm Hg, 24h-DBP 80 ± 5 mm Hg, 24h-HR 76 ± 8 bpm). The carotid-femoral pulse wave velocity (PWV) was used as a measure of arterial stiffness. Doppler echocardiography was performed using ALOKA 5000 machine equipped with 2.5–3.5 MHz transducer. LV diastolic function was described by the peak of early (E) and late (A) transmitral flow velocity, deceleration time (DT) of E and slope of E peak deceleration (Dec E).
Results Significant correlation coefficients were found between PWV and parameters of left ventricular diastolic function (PWV vs. E r = –0.531, p = 0.006; PWV vs. E/A r = –0.478, p = 0.016). The analysis of relationship between PWV and DecE revealed r = –0.353, p = 0.083. We did not observe any significant correlation between PWV and parameters of left ventricular structure (EF %, LVMI /m2), as well.
Conclusion Our study revealed significant relationship between arterial stiffness and left ventricular diastolic function in normotensive males. Therefore, increased arterial stiffness may serve as an early evidence of impaired left ventricular diastolic function. This relationship revealed in healthy subjects may indicate that alterations in heart and arterial function may be parallel.
Keywords
diastolic function; arterial stiffness
About this articleTitle
The relationship between left ventricular diastolic function and arterial stiffness in normotensive males
Journal
Issue
Article type
Original paper
Pages
403-410
Published online
2004-12-14
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815
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Bibliographic record
Nadciśnienie tętnicze 2004;8(6):403-410.
Keywords
diastolic function
arterial stiffness
Authors
Katarzyna Kunicka
Ewa Świerblewska
Dagmara Hering
Hanna Świątek
Jolanta Neubauer-Geryk
Piotr Kruszewski
Przybysława Kaczmarek-Kusznierewicz
Krzysztof Narkiewicz
Leszek Bieniaszewski
Bogdan Wyrzykowski