open access

Vol 8, No 6 (2004)
Prace oryginalne
Published online: 2004-12-14
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The relationship between left ventricular diastolic function and arterial stiffness in normotensive males

Katarzyna Kunicka, Ewa Świerblewska, Dagmara Hering, Hanna Świątek, Jolanta Neubauer-Geryk, Piotr Kruszewski, Przybysława Kaczmarek-Kusznierewicz, Krzysztof Narkiewicz, Leszek Bieniaszewski, Bogdan Wyrzykowski
Nadciśnienie tętnicze 2004;8(6):403-410.

open access

Vol 8, No 6 (2004)
Prace oryginalne
Published online: 2004-12-14

Abstract

Background Cardiovascular diseases are the main health problem in Poland. As described in numerous studies diastolic heart failure is common and causes significant alterations in prognosis. The mechanisms that cause abnormalities in diastolic function and arterial stiffness are similar and can both lead to the development of heart failure.
The aim of this study was to evaluate the relationship between left ventricular diastolic function and arterial stiffness in normotensive males.
Material and methods We examined 26 healthy male subjects aged 43 ± 8 years (BMI 26.9 ± 4.2 kg/m2, 24h-SBP 127 ± 8 mm Hg, 24h-DBP 80 ± 5 mm Hg, 24h-HR 76 ± 8 bpm). The carotid-femoral pulse wave velocity (PWV) was used as a measure of arterial stiffness. Doppler echocardiography was performed using ALOKA 5000 machine equipped with 2.5–3.5 MHz transducer. LV diastolic function was described by the peak of early (E) and late (A) transmitral flow velocity, deceleration time (DT) of E and slope of E peak deceleration (Dec E).
Results Significant correlation coefficients were found between PWV and parameters of left ventricular diastolic function (PWV vs. E r = –0.531, p = 0.006; PWV vs. E/A r = –0.478, p = 0.016). The analysis of relationship between PWV and DecE revealed r = –0.353, p = 0.083. We did not observe any significant correlation between PWV and parameters of left ventricular structure (EF %, LVMI /m2), as well.
Conclusion Our study revealed significant relationship between arterial stiffness and left ventricular diastolic function in normotensive males. Therefore, increased arterial stiffness may serve as an early evidence of impaired left ventricular diastolic function. This relationship revealed in healthy subjects may indicate that alterations in heart and arterial function may be parallel.

Abstract

Background Cardiovascular diseases are the main health problem in Poland. As described in numerous studies diastolic heart failure is common and causes significant alterations in prognosis. The mechanisms that cause abnormalities in diastolic function and arterial stiffness are similar and can both lead to the development of heart failure.
The aim of this study was to evaluate the relationship between left ventricular diastolic function and arterial stiffness in normotensive males.
Material and methods We examined 26 healthy male subjects aged 43 ± 8 years (BMI 26.9 ± 4.2 kg/m2, 24h-SBP 127 ± 8 mm Hg, 24h-DBP 80 ± 5 mm Hg, 24h-HR 76 ± 8 bpm). The carotid-femoral pulse wave velocity (PWV) was used as a measure of arterial stiffness. Doppler echocardiography was performed using ALOKA 5000 machine equipped with 2.5–3.5 MHz transducer. LV diastolic function was described by the peak of early (E) and late (A) transmitral flow velocity, deceleration time (DT) of E and slope of E peak deceleration (Dec E).
Results Significant correlation coefficients were found between PWV and parameters of left ventricular diastolic function (PWV vs. E r = –0.531, p = 0.006; PWV vs. E/A r = –0.478, p = 0.016). The analysis of relationship between PWV and DecE revealed r = –0.353, p = 0.083. We did not observe any significant correlation between PWV and parameters of left ventricular structure (EF %, LVMI /m2), as well.
Conclusion Our study revealed significant relationship between arterial stiffness and left ventricular diastolic function in normotensive males. Therefore, increased arterial stiffness may serve as an early evidence of impaired left ventricular diastolic function. This relationship revealed in healthy subjects may indicate that alterations in heart and arterial function may be parallel.
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Keywords

diastolic function; arterial stiffness

About this article
Title

The relationship between left ventricular diastolic function and arterial stiffness in normotensive males

Journal

Arterial Hypertension

Issue

Vol 8, No 6 (2004)

Pages

403-410

Published online

2004-12-14

Bibliographic record

Nadciśnienie tętnicze 2004;8(6):403-410.

Keywords

diastolic function
arterial stiffness

Authors

Katarzyna Kunicka
Ewa Świerblewska
Dagmara Hering
Hanna Świątek
Jolanta Neubauer-Geryk
Piotr Kruszewski
Przybysława Kaczmarek-Kusznierewicz
Krzysztof Narkiewicz
Leszek Bieniaszewski
Bogdan Wyrzykowski

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