The assessment of adiponectin in patients with acute coronary disease

Anna Miczke; Wiesław Bryl; Paweł Bogdański; Maciej Cymerys; Monika Szulińska; Magdalena Łuczak; Danuta Pupek-Musialik; Olga Trojnarska; Stefan Grajek

Vol 9, No 1 (2005)

Original paper

Published online: 2005-02-04

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The assessment of adiponectin in patients with acute coronary disease

Anna Miczke, Wiesław Bryl, Paweł Bogdański, Maciej Cymerys, Monika Szulińska, Magdalena Łuczak, Danuta Pupek-Musialik, Olga Trojnarska, Stefan Grajek

Nadciśnienie tętnicze 2005;9(1):31-36.

Vol 9, No 1 (2005)

Prace oryginalne

Published online: 2005-02-04

Abstract

Background Adiponectin (APM1), a protein produced in adipose tissue, takes part in pathogenesis of insulin resistance. Studies have proved also the role of APM1 in atherogenesis. Antiatherogenic properties of APM1 are associated with inhibitory effect of APM1 on adhesion molecules: VCAM-1, E-selectin, ICAM-1. APM1 increases also endothelial production of nitric oxide and inhibits proliferation of vascular smooth muscle cells. Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease (CAD) than those in age- and body mass index-adjusted control subjects.
Material and methods The study included 35 patients with CAD (age 56.3 ± 10.1, BMI 27.2 ± 4.3, WHR 0.95 ± ± 0.07). All subjects underwent coronary angiography. The patients with diabetes mellitus (t. 1 and 2), renal failure and other chronic diseases were not included into the study. All patients underwent a medical examination. ECG, lipid profile, necrosis enzymes were also determined. Adiponectin was measured by RIA (Linco Research). Taking into account the anamnesis, ECG and enzymes the study population was divided into 2 groups: 1 — acute coronary syndrome (20 patients) and 2 — stable angina (15 patients). There was a control group of 10 healthly subjects.
Results Both groups were matched by age, BMI, WHR, body fat percentage and lipid profile. Plasma adiponectin concentration was significantly lower in group with acute coronary syndrome (26.2 ± 13.3 vs. 34.9 ± 10.5 μg/ml,p < 0.05). In both examined group the APM1 concentration was lower than in the control group. In the whole group there was a negative correlation between APM1 and BMI, WHR and TAG-triacyloglicerol.
Conclusions The patients with acute coronary syndrome have lower adiponectin levels than those with stable angina. APM1 is closely associated with other cardiac risk factors (BMI, WHR, TAG).