open access

Vol 9, No 1 (2005)
Prace oryginalne
Published online: 2005-02-04
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HindIII polymorphism of the lipoprotein lipase gene and blood pressure, anthropometric measurements, carotid artery structure and selected indices of the metabolism of glucose and lipids - family study

Wojciech Lubaszewski, Katarzyna Stolarz, Agnieszka Olszanecka, Agata Jabrocka, Beata Kieć-Wilk, Aldona Dembińska-Kieć, Kalina Kawecka-Jaszcz
Nadciśnienie tętnicze 2005;9(1):11-21.

open access

Vol 9, No 1 (2005)
Prace oryginalne
Published online: 2005-02-04

Abstract

Background The prevalence of the metabolic syndrome, which includes essential hypertension, is continuously increasing. The aim of the study was to evaluate the influence of the lipoprotein lipase (LPL) gene HindIII polymorphism on blood pressure (BP), obesity, fasting glucose and lipoprotein profile, as well as carotid intima-media thickness (IMT) in the cohort of Polish families.
Material and methods We genotyped 326 subjects, members of 86 nuclear families, enrolled in the populationbased study, for the HindIII polymorphism of the LLP gene. We excluded from this analysis 15 subjects with diabetes mellitus. Remaining 311 persons underwent conventional BP measurement during two separate home visits, 5 times on each visit. Anthropometric data were collected with standardized protocol. Peripheral blood was sampled in fasting subjects for routine biochemistry, including glucose and lipoprotein profile. Carotid IMT measured by carotid ultrasound was used as an index of atherosclerosis.
Results Genotype frequencies were 55.0% for +/+, 36.7% for +/– and 8.3% for –/–, and did not deviate from the Hardy-Weinberg equilibrium (p = 0.44). Among parents (mean age: 50.7 years) –/– homozygotes as compared to (+) allele carriers showed increased body mass index (31.6 vs. 28.0 kg/m2; p = 0.01) and increased total cholesterol (6.23 vs. 5.56 mmol/l; p = 0.05). Parents homozygous for (–) allele presented also tendency towards higher levels of LDL cholesterol (3.92 vs. 3.29 mmol/l; p = 0.06) and carotid IMT (0.87 vs. 0.71 mm; p = 0.09). In offspring generation (mean age: 24.1 years), carrying of (–) allele resulted in higher fasting glucose (4.48 vs. 4.12 mmol/l; p = 0.003), total cholesterol (4.71 vs. 4.37 mmol/l; p = 0.01) and LDL cholesterol (2.58 vs. 2.33 mmol/l; p = 0.04). In quantitative transmission disequillibrium test, HindIII polymorphism of LPL mainly influenced fasting glucose levels (chi2 = 6.62, p = 0.01).
Conclusions HindIII polymorphism of the lipoprotein lipase gene influences lipids metabolism in both generations and in offspring generation also glucose metabolism. In parents generation, it is also related to obesity and increased carotid IMT.

Abstract

Background The prevalence of the metabolic syndrome, which includes essential hypertension, is continuously increasing. The aim of the study was to evaluate the influence of the lipoprotein lipase (LPL) gene HindIII polymorphism on blood pressure (BP), obesity, fasting glucose and lipoprotein profile, as well as carotid intima-media thickness (IMT) in the cohort of Polish families.
Material and methods We genotyped 326 subjects, members of 86 nuclear families, enrolled in the populationbased study, for the HindIII polymorphism of the LLP gene. We excluded from this analysis 15 subjects with diabetes mellitus. Remaining 311 persons underwent conventional BP measurement during two separate home visits, 5 times on each visit. Anthropometric data were collected with standardized protocol. Peripheral blood was sampled in fasting subjects for routine biochemistry, including glucose and lipoprotein profile. Carotid IMT measured by carotid ultrasound was used as an index of atherosclerosis.
Results Genotype frequencies were 55.0% for +/+, 36.7% for +/– and 8.3% for –/–, and did not deviate from the Hardy-Weinberg equilibrium (p = 0.44). Among parents (mean age: 50.7 years) –/– homozygotes as compared to (+) allele carriers showed increased body mass index (31.6 vs. 28.0 kg/m2; p = 0.01) and increased total cholesterol (6.23 vs. 5.56 mmol/l; p = 0.05). Parents homozygous for (–) allele presented also tendency towards higher levels of LDL cholesterol (3.92 vs. 3.29 mmol/l; p = 0.06) and carotid IMT (0.87 vs. 0.71 mm; p = 0.09). In offspring generation (mean age: 24.1 years), carrying of (–) allele resulted in higher fasting glucose (4.48 vs. 4.12 mmol/l; p = 0.003), total cholesterol (4.71 vs. 4.37 mmol/l; p = 0.01) and LDL cholesterol (2.58 vs. 2.33 mmol/l; p = 0.04). In quantitative transmission disequillibrium test, HindIII polymorphism of LPL mainly influenced fasting glucose levels (chi2 = 6.62, p = 0.01).
Conclusions HindIII polymorphism of the lipoprotein lipase gene influences lipids metabolism in both generations and in offspring generation also glucose metabolism. In parents generation, it is also related to obesity and increased carotid IMT.
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Keywords

blood pressure; carotid intima-media thickness; metabolic syndrome; lipoprotein lipase; polymorphism

About this article
Title

HindIII polymorphism of the lipoprotein lipase gene and blood pressure, anthropometric measurements, carotid artery structure and selected indices of the metabolism of glucose and lipids - family study

Journal

Arterial Hypertension

Issue

Vol 9, No 1 (2005)

Pages

11-21

Published online

2005-02-04

Bibliographic record

Nadciśnienie tętnicze 2005;9(1):11-21.

Keywords

blood pressure
carotid intima-media thickness
metabolic syndrome
lipoprotein lipase
polymorphism

Authors

Wojciech Lubaszewski
Katarzyna Stolarz
Agnieszka Olszanecka
Agata Jabrocka
Beata Kieć-Wilk
Aldona Dembińska-Kieć
Kalina Kawecka-Jaszcz

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