Vol 9, No 2 (2005)
Original paper
Published online: 2005-04-11
Selected parameters of endothelial function in patients with uncomplicated arterial hypertension and with risk factors of atherosclerosis
Nadciśnienie tętnicze 2005;9(2):118-125.
Abstract
Background Selected parameters of endothelial function in patients with uncomplicated arterial hypertension and with risk factors of atherosclerosis.
Vascular endothelium dysfunction plays an important role in arterial hypertension pathogenesis. Its development is affected by the risk factors of atherosclerosis.
Evaluation of the concentration of nitric oxide metabolites (nitrites and nitrates-Nox) and endothelin-1 (ET-1) in plasma as well as cyclic 3.5 guanosine monophosphate (cGMP) in 24-hour urine collection in patients with uncomplicated arterial hypertension and without risk factors of atherosclerosis.
Material and methods The study comprised 45 subjects (30 men and 15 women) aged 45 ± 6.6 years, divided into 3 groups: I — controls (clinically healthy subjects), II — patients with arterial hypertension without risk factors of atherosclerosis and III — patients with hypertension and with risk factors of atherosclerosis. Plasma Nox concentration was determined with Griess method, plasma ET-1 with ELISA and cGMP in urine with immunoenzymatic method.
Results Plasma Nox concentration in group I was 15.86 ± ± 6.32 μmol/L, in group II — 18.62 ± 5.84 μmol/L, and in group III — 9.96 ± 4.72 μmol/L. The differences were statistically significant between groups I and III (p < 0.05). The concentration of cGMP in urine was in group I — 40 ± 24 pmol/L, in group II — 54 ± 41 pmol/L and in group III — 38 ± pmol/L. The differences between the groups were statistically insignificant. The plasma ET-1 concentration was in group I — 3.83 ± 0.69 pg/mL, in group II — 3.98 ± 0.71 pg/mL and in group III — 4.22 ± 0,64 pg/mL. The differences were statistically significant between groups I and III, p < 0.05.
Conclusion In patients with uncomplicated arterial hypertension risk factors of atherosclerosis deteriorate significantly the function of vascular endothelium.
Vascular endothelium dysfunction plays an important role in arterial hypertension pathogenesis. Its development is affected by the risk factors of atherosclerosis.
Evaluation of the concentration of nitric oxide metabolites (nitrites and nitrates-Nox) and endothelin-1 (ET-1) in plasma as well as cyclic 3.5 guanosine monophosphate (cGMP) in 24-hour urine collection in patients with uncomplicated arterial hypertension and without risk factors of atherosclerosis.
Material and methods The study comprised 45 subjects (30 men and 15 women) aged 45 ± 6.6 years, divided into 3 groups: I — controls (clinically healthy subjects), II — patients with arterial hypertension without risk factors of atherosclerosis and III — patients with hypertension and with risk factors of atherosclerosis. Plasma Nox concentration was determined with Griess method, plasma ET-1 with ELISA and cGMP in urine with immunoenzymatic method.
Results Plasma Nox concentration in group I was 15.86 ± ± 6.32 μmol/L, in group II — 18.62 ± 5.84 μmol/L, and in group III — 9.96 ± 4.72 μmol/L. The differences were statistically significant between groups I and III (p < 0.05). The concentration of cGMP in urine was in group I — 40 ± 24 pmol/L, in group II — 54 ± 41 pmol/L and in group III — 38 ± pmol/L. The differences between the groups were statistically insignificant. The plasma ET-1 concentration was in group I — 3.83 ± 0.69 pg/mL, in group II — 3.98 ± 0.71 pg/mL and in group III — 4.22 ± 0,64 pg/mL. The differences were statistically significant between groups I and III, p < 0.05.
Conclusion In patients with uncomplicated arterial hypertension risk factors of atherosclerosis deteriorate significantly the function of vascular endothelium.
Keywords: arterial hypertensionnitrites and nitratescyclic GMPendothelin-1risk factors of atherosclerosis