open access

Vol 9, No 2 (2005)
Prace oryginalne
Published online: 2005-04-11
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Influence of L-carnitine on left ventricular mass, their systolic and diastolic function, circadian blood pressure profile and heart rate variability in chronic renal failure patients undergoing hemodialysis therapy

Maria Wanic-Kossowska, Andrzej Tykarski, Jerzy Płotast, Mikołaj Kobelski, Stanisław Czekalski
Nadciśnienie tętnicze 2005;9(2):103-111.

open access

Vol 9, No 2 (2005)
Prace oryginalne
Published online: 2005-04-11

Abstract

Background The aim of our study was to evaluate the influence of L-carnitine treatment on the left ventricular mass, it’s systolic-diastolic function, exercise capacity and blood pressure.
Material and methods The study was performed in 20 patients (11 females, 9 males) mean age 52.10 ± 15.72 years, duration of hemodialysis therapy 33.84 ± 20.41 months. Patients obtained L-carnitine (Carnivit) orally at the daily dose 4 × 250 mg during the following 6 months. Before and after the treatment in all patients echocardiography, treadmill stress test, ECG, 24-hour blood pressure monitoring and 24-hour ECG monitoring and carnitine serum levels were evaluated. The control group consisted of 10 patients (5 females, 5 males, mean age 50.23 ± 18.10 years, duration of hemodialysis therapy 41.2 ± 23.12 months) with crf and without L-carnitine treatment. In those patients echocardiography, treadmill stress test and carnitine serum levels were evaluated.
Results The second control grup consisted of 30 age and sex-matched healthy subjects (18 females, 12 males, mean age 41.2 ± 18.6 years). After 6 months of L-carnitine treatment left ventricular mass (LVM), relative wall thickness (RWT), posterior wall thickness (PWT) and interventricular septum (IVS) were significantly (p < 0.05) decreased. Systolic and diastolic left ventricular function signifiacantly improved, isovolumic relaxation time (IVRT) significantly (p < 0.05) decreased and ejection fraction (LVEF) increased. Exercise capacity measured during treadmill stress test improved, patients in NYHA II/III class were improved to NYHA II. The correlations between carnitine serum levels and PW, IVS, RWT, time and load during exercise treadmill stress test confirm the positive influence of L-carnitine treatment on regression of left ventricular hypertrophy as well as on it’s systolic-diastolic function and exercise capacity.
Conclusion L-carnitine treatment has no influence on blood pressure, ischemic changes in ECG examination and heart rate variability.

Abstract

Background The aim of our study was to evaluate the influence of L-carnitine treatment on the left ventricular mass, it’s systolic-diastolic function, exercise capacity and blood pressure.
Material and methods The study was performed in 20 patients (11 females, 9 males) mean age 52.10 ± 15.72 years, duration of hemodialysis therapy 33.84 ± 20.41 months. Patients obtained L-carnitine (Carnivit) orally at the daily dose 4 × 250 mg during the following 6 months. Before and after the treatment in all patients echocardiography, treadmill stress test, ECG, 24-hour blood pressure monitoring and 24-hour ECG monitoring and carnitine serum levels were evaluated. The control group consisted of 10 patients (5 females, 5 males, mean age 50.23 ± 18.10 years, duration of hemodialysis therapy 41.2 ± 23.12 months) with crf and without L-carnitine treatment. In those patients echocardiography, treadmill stress test and carnitine serum levels were evaluated.
Results The second control grup consisted of 30 age and sex-matched healthy subjects (18 females, 12 males, mean age 41.2 ± 18.6 years). After 6 months of L-carnitine treatment left ventricular mass (LVM), relative wall thickness (RWT), posterior wall thickness (PWT) and interventricular septum (IVS) were significantly (p < 0.05) decreased. Systolic and diastolic left ventricular function signifiacantly improved, isovolumic relaxation time (IVRT) significantly (p < 0.05) decreased and ejection fraction (LVEF) increased. Exercise capacity measured during treadmill stress test improved, patients in NYHA II/III class were improved to NYHA II. The correlations between carnitine serum levels and PW, IVS, RWT, time and load during exercise treadmill stress test confirm the positive influence of L-carnitine treatment on regression of left ventricular hypertrophy as well as on it’s systolic-diastolic function and exercise capacity.
Conclusion L-carnitine treatment has no influence on blood pressure, ischemic changes in ECG examination and heart rate variability.
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Keywords

chronic renal failure; hemodialysis; L-carnitine

About this article
Title

Influence of L-carnitine on left ventricular mass, their systolic and diastolic function, circadian blood pressure profile and heart rate variability in chronic renal failure patients undergoing hemodialysis therapy

Journal

Arterial Hypertension

Issue

Vol 9, No 2 (2005)

Pages

103-111

Published online

2005-04-11

Bibliographic record

Nadciśnienie tętnicze 2005;9(2):103-111.

Keywords

chronic renal failure
hemodialysis
L-carnitine

Authors

Maria Wanic-Kossowska
Andrzej Tykarski
Jerzy Płotast
Mikołaj Kobelski
Stanisław Czekalski

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