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Influence of L-carnitine on left ventricular mass, their systolic and diastolic function, circadian blood pressure profile and heart rate variability in chronic renal failure patients undergoing hemodialysis therapy
open access
Abstract
Material and methods The study was performed in 20 patients (11 females, 9 males) mean age 52.10 ± 15.72 years, duration of hemodialysis therapy 33.84 ± 20.41 months. Patients obtained L-carnitine (Carnivit) orally at the daily dose 4 × 250 mg during the following 6 months. Before and after the treatment in all patients echocardiography, treadmill stress test, ECG, 24-hour blood pressure monitoring and 24-hour ECG monitoring and carnitine serum levels were evaluated. The control group consisted of 10 patients (5 females, 5 males, mean age 50.23 ± 18.10 years, duration of hemodialysis therapy 41.2 ± 23.12 months) with crf and without L-carnitine treatment. In those patients echocardiography, treadmill stress test and carnitine serum levels were evaluated.
Results The second control grup consisted of 30 age and sex-matched healthy subjects (18 females, 12 males, mean age 41.2 ± 18.6 years). After 6 months of L-carnitine treatment left ventricular mass (LVM), relative wall thickness (RWT), posterior wall thickness (PWT) and interventricular septum (IVS) were significantly (p < 0.05) decreased. Systolic and diastolic left ventricular function signifiacantly improved, isovolumic relaxation time (IVRT) significantly (p < 0.05) decreased and ejection fraction (LVEF) increased. Exercise capacity measured during treadmill stress test improved, patients in NYHA II/III class were improved to NYHA II. The correlations between carnitine serum levels and PW, IVS, RWT, time and load during exercise treadmill stress test confirm the positive influence of L-carnitine treatment on regression of left ventricular hypertrophy as well as on it’s systolic-diastolic function and exercise capacity.
Conclusion L-carnitine treatment has no influence on blood pressure, ischemic changes in ECG examination and heart rate variability.
Abstract
Material and methods The study was performed in 20 patients (11 females, 9 males) mean age 52.10 ± 15.72 years, duration of hemodialysis therapy 33.84 ± 20.41 months. Patients obtained L-carnitine (Carnivit) orally at the daily dose 4 × 250 mg during the following 6 months. Before and after the treatment in all patients echocardiography, treadmill stress test, ECG, 24-hour blood pressure monitoring and 24-hour ECG monitoring and carnitine serum levels were evaluated. The control group consisted of 10 patients (5 females, 5 males, mean age 50.23 ± 18.10 years, duration of hemodialysis therapy 41.2 ± 23.12 months) with crf and without L-carnitine treatment. In those patients echocardiography, treadmill stress test and carnitine serum levels were evaluated.
Results The second control grup consisted of 30 age and sex-matched healthy subjects (18 females, 12 males, mean age 41.2 ± 18.6 years). After 6 months of L-carnitine treatment left ventricular mass (LVM), relative wall thickness (RWT), posterior wall thickness (PWT) and interventricular septum (IVS) were significantly (p < 0.05) decreased. Systolic and diastolic left ventricular function signifiacantly improved, isovolumic relaxation time (IVRT) significantly (p < 0.05) decreased and ejection fraction (LVEF) increased. Exercise capacity measured during treadmill stress test improved, patients in NYHA II/III class were improved to NYHA II. The correlations between carnitine serum levels and PW, IVS, RWT, time and load during exercise treadmill stress test confirm the positive influence of L-carnitine treatment on regression of left ventricular hypertrophy as well as on it’s systolic-diastolic function and exercise capacity.
Conclusion L-carnitine treatment has no influence on blood pressure, ischemic changes in ECG examination and heart rate variability.
Keywords
chronic renal failure; hemodialysis; L-carnitine
Title
Influence of L-carnitine on left ventricular mass, their systolic and diastolic function, circadian blood pressure profile and heart rate variability in chronic renal failure patients undergoing hemodialysis therapy
Journal
Issue
Article type
Original paper
Pages
103-111
Published online
2005-04-11
Page views
2852
Article views/downloads
2535
Bibliographic record
Nadciśnienie tętnicze 2005;9(2):103-111.
Keywords
chronic renal failure
hemodialysis
L-carnitine
Authors
Maria Wanic-Kossowska
Andrzej Tykarski
Jerzy Płotast
Mikołaj Kobelski
Stanisław Czekalski