open access

Vol 9, No 3 (2005)
Prace oryginalne
Published online: 2005-05-11
Get Citation

Assessment of selected markers of inflammation in patients with arterial hypertension and clinical manifestation of metabolic syndrome

Paweł Bogdański, Danuta Pupek-Musialik, Joanna Dytfeld, Anna Miczke, Wiesław Bryl, Anna Jabłecka, Magdalena Kujawska-Łuczak, Maciej Cymerys, Katarzyna Musialik
Nadciśnienie tętnicze 2005;9(3):194-201.

open access

Vol 9, No 3 (2005)
Prace oryginalne
Published online: 2005-05-11

Abstract

Background Arterial hypertension is often accompanied by metabolic disorders. Isolated hypertension as well as metabolic syndrome lead to an inflammatory state which is probably responsible for the initiation and progression of atherogenesis in these groups of patients. The aim of the study was to evaluate certain markers of inflammatory reaction in patients with hypertension and coexisting metabolic disorders and to examine correlations between grade of inflammatory process and metabolic and biochemical parameters.
Materials and methods The study group comprised 44 patients with essential hypertension constituting one of definable component of metabolic syndrome according to ATP III (group I) and 26 persons with hypertension accompanied by only one component of metabolic syndrome (group II). The control group consisted of 12 healthy volunteers. Serum concentration of tumor necrosis factor soluble receptor type 2 (sTNFR2), soluble intercellular adhesion molecule (sICAM-1) and fasting insulin were measured. Insulin resisrtance ratio (IRI/G) was calculated. Fat content was evaluated using bioimpedancy method.
Results Higher concentrations of sTNFR2 and sICAM 1 were observed in both study groups when compared to the control group. In group I concentrations of both parameters were significantly higher in comparison with group II. The obese hypertensives with dyslipidemia presented higher concentrations of the studied cytokines than the slim ones, as well as the obese diabetic hypertensives with dyslipidemia when compared to non-diabetic ones. Along with the increasing number of definable components of the metabolic syndrome the serum concentrations of sTNFR2 and sICAM 1 were also found to elevate. Finally, in case of diabetes accompanying other metabolic disorders, the concentrations of studied parameters were observed to be the highest. In patients with hypertension and visceral obesity and no diabetes positive correlations between sTNFR2 and %FAT, insulin and IRI/G ratio were proven.
Conclusions 1. Hypertension and other features of insulin resistance are associated with aggravation of an inflammatory process. 2. Aggravation of an inflammatory reaction in patients with hypertension is becoming more distinct along with increasing number of definable components of the metabolic syndrome 3. It seems that diabetes mellitus in the highest extent contributes to aggravation of an inflammatory reaction 4. Chronic inflammation should be considered as an important feature in development of atherogenesis in patients with "metabolic" hypertension. 5. Positive correlations between sTNFR2 and %FAT, insulin and IRI/G ratio can be considered as a potential circumstance for crucial role of TNF system in complex pathogenesis of insulin resistance in obese patients.

Abstract

Background Arterial hypertension is often accompanied by metabolic disorders. Isolated hypertension as well as metabolic syndrome lead to an inflammatory state which is probably responsible for the initiation and progression of atherogenesis in these groups of patients. The aim of the study was to evaluate certain markers of inflammatory reaction in patients with hypertension and coexisting metabolic disorders and to examine correlations between grade of inflammatory process and metabolic and biochemical parameters.
Materials and methods The study group comprised 44 patients with essential hypertension constituting one of definable component of metabolic syndrome according to ATP III (group I) and 26 persons with hypertension accompanied by only one component of metabolic syndrome (group II). The control group consisted of 12 healthy volunteers. Serum concentration of tumor necrosis factor soluble receptor type 2 (sTNFR2), soluble intercellular adhesion molecule (sICAM-1) and fasting insulin were measured. Insulin resisrtance ratio (IRI/G) was calculated. Fat content was evaluated using bioimpedancy method.
Results Higher concentrations of sTNFR2 and sICAM 1 were observed in both study groups when compared to the control group. In group I concentrations of both parameters were significantly higher in comparison with group II. The obese hypertensives with dyslipidemia presented higher concentrations of the studied cytokines than the slim ones, as well as the obese diabetic hypertensives with dyslipidemia when compared to non-diabetic ones. Along with the increasing number of definable components of the metabolic syndrome the serum concentrations of sTNFR2 and sICAM 1 were also found to elevate. Finally, in case of diabetes accompanying other metabolic disorders, the concentrations of studied parameters were observed to be the highest. In patients with hypertension and visceral obesity and no diabetes positive correlations between sTNFR2 and %FAT, insulin and IRI/G ratio were proven.
Conclusions 1. Hypertension and other features of insulin resistance are associated with aggravation of an inflammatory process. 2. Aggravation of an inflammatory reaction in patients with hypertension is becoming more distinct along with increasing number of definable components of the metabolic syndrome 3. It seems that diabetes mellitus in the highest extent contributes to aggravation of an inflammatory reaction 4. Chronic inflammation should be considered as an important feature in development of atherogenesis in patients with "metabolic" hypertension. 5. Positive correlations between sTNFR2 and %FAT, insulin and IRI/G ratio can be considered as a potential circumstance for crucial role of TNF system in complex pathogenesis of insulin resistance in obese patients.
Get Citation

Keywords

hypertension; insulin resistance; inflammation; atherogenesis

About this article
Title

Assessment of selected markers of inflammation in patients with arterial hypertension and clinical manifestation of metabolic syndrome

Journal

Arterial Hypertension

Issue

Vol 9, No 3 (2005)

Pages

194-201

Published online

2005-05-11

Bibliographic record

Nadciśnienie tętnicze 2005;9(3):194-201.

Keywords

hypertension
insulin resistance
inflammation
atherogenesis

Authors

Paweł Bogdański
Danuta Pupek-Musialik
Joanna Dytfeld
Anna Miczke
Wiesław Bryl
Anna Jabłecka
Magdalena Kujawska-Łuczak
Maciej Cymerys
Katarzyna Musialik

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl