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The effect of myocardial revascularization by means of percutaneous transluminal coronary angioplasty on plasma NT-proBNP concentration in patients with and without primary arterial hypertension
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Abstract
Material and methods 80 patients divided into 3 groups were studied: I group: 30 patients with ischemic heart disease (IHD), confirmed during coronarography (CA), and with essential HA, who had recently undergone PTCA, II group: 30 patients with IHD, confirmed during CA, but without HA, who had recently undergone PTCA, III group: 20 patients with HA but free of IHD, confirmed during CA. The groups were similar with regard to age and body mass index. Blood samples were collected twice: 24 hours before and 24 hours after PTCA or CA. For plasma NT-proBNP measurements the electrochemiluminescence immunoassay was used (Elecsys, Roche Diagnostics).
Results The plasma NT-proBNP concentrations increased significantly after PTCA both in the group of patients with HA (193.3 ± 168.4 pg/ml vs. 289.8 ± 358.6 pg/ml; p < 0.05), and without HA (165.7 ± 101.2 pg/ml vs. 207.9 ± 152.1 pg/ml; p < 0.05). There was no significant difference in plasma NT-proBNP concentration after CA in the control group. There were no significant differences in the change in plasma NT-proBNP concentration after PTCA in patients with and without HA. The relative change in plasma NT-proBNP concentration after PTCA showed a similar pattern.
Conclusions Successful myocardial revascularization by means of PTCA results in rise in plasma NT-proBNP concentration. This effect is not related to CA. The presence of hypertensive disease does not affect on NT-proBNP concentration after PTCA. It seems that the presence of hypertension does not increase also impairement of left ventricul hemodynamic parameters leading to increase of NT-proBNP concentration immediately after PTCA.
Abstract
Material and methods 80 patients divided into 3 groups were studied: I group: 30 patients with ischemic heart disease (IHD), confirmed during coronarography (CA), and with essential HA, who had recently undergone PTCA, II group: 30 patients with IHD, confirmed during CA, but without HA, who had recently undergone PTCA, III group: 20 patients with HA but free of IHD, confirmed during CA. The groups were similar with regard to age and body mass index. Blood samples were collected twice: 24 hours before and 24 hours after PTCA or CA. For plasma NT-proBNP measurements the electrochemiluminescence immunoassay was used (Elecsys, Roche Diagnostics).
Results The plasma NT-proBNP concentrations increased significantly after PTCA both in the group of patients with HA (193.3 ± 168.4 pg/ml vs. 289.8 ± 358.6 pg/ml; p < 0.05), and without HA (165.7 ± 101.2 pg/ml vs. 207.9 ± 152.1 pg/ml; p < 0.05). There was no significant difference in plasma NT-proBNP concentration after CA in the control group. There were no significant differences in the change in plasma NT-proBNP concentration after PTCA in patients with and without HA. The relative change in plasma NT-proBNP concentration after PTCA showed a similar pattern.
Conclusions Successful myocardial revascularization by means of PTCA results in rise in plasma NT-proBNP concentration. This effect is not related to CA. The presence of hypertensive disease does not affect on NT-proBNP concentration after PTCA. It seems that the presence of hypertension does not increase also impairement of left ventricul hemodynamic parameters leading to increase of NT-proBNP concentration immediately after PTCA.
Keywords
BNP; coronary angioplasty; ischemic heart disease; hypertension
Title
The effect of myocardial revascularization by means of percutaneous transluminal coronary angioplasty on plasma NT-proBNP concentration in patients with and without primary arterial hypertension
Journal
Issue
Article type
Original paper
Pages
184-193
Published online
2005-05-11
Page views
569
Article views/downloads
1525
Bibliographic record
Nadciśnienie tętnicze 2005;9(3):184-193.
Keywords
BNP
coronary angioplasty
ischemic heart disease
hypertension
Authors
Urszula Brzezinska
Andrzej Tykarski