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Evaluation of concentration of lipid peroxidation products and of antioxidant enzymes activity in patients with essential hypertension
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Abstract
Material and methods The study included 50 patients with essential arterial hypertension and 47 healthy controls. Patients were divided into 2 groups: I (28 patients) with sufficient control of arterial hypertension and II (22 patients) with insufficient control of arterial hypertension during hypertension treatment. We evaluated the level of peroxidation lipid products (expressed as the concentration of malondialdehyde in erythrocytes and in plasma) and the activity of antioxidant enzymes (catalase, glutathione peroxidase, superoxide dismutase) in erythrocytes.
Results There were no statistically significant differences between patients with arterial hypertension and controls, and between 2 groups of patients with arterial hypertension in the lipid peroxidation products concentration and in the activity of catalase and glutathione peroxidase. However, the activity of superoxide dismutase was higher in patients with arterial hypertension. The higher activity of superoxide dismutase was independent from the level of arterial hypertension control and left ventricle hypertrophy.
Conclusions Treatment of arterial hypertension may have influence on the lipid peroxidation products level. The higher activity of superoxide dismutase may be compensatory mechanism, which influence on the concentration of lipid peroxidation products.
Abstract
Material and methods The study included 50 patients with essential arterial hypertension and 47 healthy controls. Patients were divided into 2 groups: I (28 patients) with sufficient control of arterial hypertension and II (22 patients) with insufficient control of arterial hypertension during hypertension treatment. We evaluated the level of peroxidation lipid products (expressed as the concentration of malondialdehyde in erythrocytes and in plasma) and the activity of antioxidant enzymes (catalase, glutathione peroxidase, superoxide dismutase) in erythrocytes.
Results There were no statistically significant differences between patients with arterial hypertension and controls, and between 2 groups of patients with arterial hypertension in the lipid peroxidation products concentration and in the activity of catalase and glutathione peroxidase. However, the activity of superoxide dismutase was higher in patients with arterial hypertension. The higher activity of superoxide dismutase was independent from the level of arterial hypertension control and left ventricle hypertrophy.
Conclusions Treatment of arterial hypertension may have influence on the lipid peroxidation products level. The higher activity of superoxide dismutase may be compensatory mechanism, which influence on the concentration of lipid peroxidation products.
Keywords
arterial hypertension; lipid peroxidation products; antioxidant enzymes
About this articleTitle
Evaluation of concentration of lipid peroxidation products and of antioxidant enzymes activity in patients with essential hypertension
Journal
Issue
Article type
Original paper
Pages
178-183
Published online
2005-05-11
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762
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1488
Bibliographic record
Nadciśnienie tętnicze 2005;9(3):178-183.
Keywords
arterial hypertension
lipid peroxidation products
antioxidant enzymes
Authors
Małgorzata Maria Rozwodowska
Mirosława Rozwodowska
Iwona Świątkiewicz
Marek Woźnicki
Anna Król
Jacek Kubica
Ewa Krzyżyńska-Malinowska
Rafał Musiak