open access

Vol 9, No 3 (2005)
Artykuły redakcyjne
Published online: 2005-05-11
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Subclinical target organ damage in patients with essential hypertension

Magdalena Gajewska, Ewa Michalak, Piotr Hoffman, Andrzej Januszewicz
Nadciśnienie tętnicze 2005;9(3):157-167.

open access

Vol 9, No 3 (2005)
Artykuły redakcyjne
Published online: 2005-05-11

Abstract

Assessment of subclinical target organ damage is a key element in the management of patients with hypertension. Impaired diastolic function and increased LV mass are common findings in hypertensive patients and may occur early in the natural history of hypertension. Ultrasonographic measurements of intima-media thickness (IMT) in carotid arteries are being applied extensively and have been regarded as a valid indicator of atherosclerosis. Several studies showed association between IMT and hypertensive target organ damage, cardiovascular events and risk factors. Microalbuminuria is a marker for generalized vascular dysfunction, is the earliest sign of nephropathy and predicts target organ damage, notably renal disease. Hypertensive patients with microalbuminuria had a significantly higher prevalence of CAD, LV hypertrophy, MI and stroke. The modern goal of the treatment of hypertension is to prevent progression, or even to reverse, subclinical target organ damage.

Abstract

Assessment of subclinical target organ damage is a key element in the management of patients with hypertension. Impaired diastolic function and increased LV mass are common findings in hypertensive patients and may occur early in the natural history of hypertension. Ultrasonographic measurements of intima-media thickness (IMT) in carotid arteries are being applied extensively and have been regarded as a valid indicator of atherosclerosis. Several studies showed association between IMT and hypertensive target organ damage, cardiovascular events and risk factors. Microalbuminuria is a marker for generalized vascular dysfunction, is the earliest sign of nephropathy and predicts target organ damage, notably renal disease. Hypertensive patients with microalbuminuria had a significantly higher prevalence of CAD, LV hypertrophy, MI and stroke. The modern goal of the treatment of hypertension is to prevent progression, or even to reverse, subclinical target organ damage.
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Keywords

hypertension; cardiovascular system; subclinical target organ damage; microalbuminuria

About this article
Title

Subclinical target organ damage in patients with essential hypertension

Journal

Arterial Hypertension

Issue

Vol 9, No 3 (2005)

Pages

157-167

Published online

2005-05-11

Bibliographic record

Nadciśnienie tętnicze 2005;9(3):157-167.

Keywords

hypertension
cardiovascular system
subclinical target organ damage
microalbuminuria

Authors

Magdalena Gajewska
Ewa Michalak
Piotr Hoffman
Andrzej Januszewicz

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