open access
The role of moxonidine in the treatment of vasovagal syncope and primary hypertension
open access
Abstract
Material and methods 40 patients (32% male, mean age 60 ± 10.8 years) with history of recurrent syncope and mild or moderate hypertension were involved in research. In control group were 20 patients (30% male, mean age 59 ± 11.4 years) with mild or moderate hypertension without syncope. In all patients were performed: the initial history, HRV analysis, ambulatory blood pressure monitoring and head-up tilt testing (HUTT) before and during the treatment of moxonidine.
Results In the patients with VVS and hypertension during the therapy of moxonidine significant reduce of number of syncope (p < 0.001), of prodromal symptoms (p < 0.01) and substantial reduce of positive outcome of HUTT (p < 0.001) were documented. Moreover in this group of patients no statistic differences in LF parameters after tilting in comparison to control group and before therapy were noted.
Conclusions Moxonidine beyond the hypotensive effect reduces frequency of syncope and elevated activity of sympathetic component in patients with vasovagal syncope and hypertension.
Abstract
Material and methods 40 patients (32% male, mean age 60 ± 10.8 years) with history of recurrent syncope and mild or moderate hypertension were involved in research. In control group were 20 patients (30% male, mean age 59 ± 11.4 years) with mild or moderate hypertension without syncope. In all patients were performed: the initial history, HRV analysis, ambulatory blood pressure monitoring and head-up tilt testing (HUTT) before and during the treatment of moxonidine.
Results In the patients with VVS and hypertension during the therapy of moxonidine significant reduce of number of syncope (p < 0.001), of prodromal symptoms (p < 0.01) and substantial reduce of positive outcome of HUTT (p < 0.001) were documented. Moreover in this group of patients no statistic differences in LF parameters after tilting in comparison to control group and before therapy were noted.
Conclusions Moxonidine beyond the hypotensive effect reduces frequency of syncope and elevated activity of sympathetic component in patients with vasovagal syncope and hypertension.
Keywords
vasovagal syncope; hypertension; therapy; heart rate variability
Title
The role of moxonidine in the treatment of vasovagal syncope and primary hypertension
Journal
Issue
Article type
Original paper
Pages
276-284
Published online
2005-08-05
Page views
567
Article views/downloads
3785
Bibliographic record
Nadciśnienie tętnicze 2005;9(4):276-284.
Keywords
vasovagal syncope
hypertension
therapy
heart rate variability
Authors
Małgorzata Lelonek
Jan Henryk Goch